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ALK-5 Protein, Human, Recombinant (His & hFc)

产品编号 TMPY-01358

别名: tβR-I, ALK5, AAT5, TGFR-1, LDS2A, LDS1, transforming growth factor, beta receptor 1, ACVRLK4, SKR4, LDS1A, tbetaR-I, ALK-5, ESS1, MSSE, transforming growth factor, β receptor 1

ALK-5 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36897-1.

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ALK-5 Protein, Human, Recombinant (His & hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,170		5日内发货

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生物活性

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参考文献

生物活性	1. Measured by its binding ability in a functional ELISA. Immobilized mouse CD105 at 10 μg/ml (100 μl/well) can bind human TGFRB1 with a linear range of 6.4-800 ng/ml. 2. Measured by its ability to bind human CD105 in a functional ELISA.
产品描述	ALK-5 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36897-1.

种属	Human
表达系统	HEK293 Cells
标签	His, hFc
蛋白编号	P36897-1
别名	tβR-I, ALK5, AAT5, TGFR-1, LDS2A, LDS1, transforming growth factor, beta receptor 1, ACVRLK4, SKR4, LDS1A, tbetaR-I, ALK-5, ESS1, MSSE, transforming growth factor, β receptor 1
蛋白构建	The Human TGFBR1 (NP_004603.1) extracellular domain (Met 1-Glu 125) was fused with the C-terminal polyhistidine-tagged Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	38.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a single-pass type I membrane protein that belongs to the protein kinase superfamily and TGFB receptor subfamily. TGFBR1 / ALK-5 is found in all tissues examined. It is most abundant in placenta and least abundant in brain and heart. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. On ligand binding, TGFBR1 / ALK-5 forms a receptor complex consisting of two type I I and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which auto-phosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta signaling via TGFBR1 / ALK-5 is not required in myocardial cells during mammalian cardiac development, but plays an irreplaceable cell-autonomous role regulating cellular communication, differentiation and proliferation in endocardial and epicardial cells. Defects in TGFBR1 / ALK-5 are the cause of Loeys-Dietz syndrome type 1A (LDS1A), Loeys-Dietz syndrome type 2A (LDS2A), and aortic aneurysm familial thoracic type 5 (AAT5).

参考文献

1. Seki T,et al.(2006) Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development. Lab Invest. 86(2): 116-29. 2. Piek E,et al.(1999) TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci. 112 (24): 4557-68. 3. Dudas M,et al.(2004) Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol. 266(1): 96-108.

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Keywords

ALK-5 Protein, Human, Recombinant (His & hFc) tβR-I ALK5 TGFR 1 AAT 5 LDS 1 AAT5 AAT-5 ACVRLK 4 TGFR-1 transforming growth factor, b receptor 1 ESS-1 LDS-1 LDS2A ESS 1 ALK 5 LDS1 transforming growth factor, beta receptor 1 ACVRLK4 SKR 4 SKR-4 SKR4 LDS1A tbetaR-I ALK-5 ESS1 MSSE TGFR1 transforming growth factor, β receptor 1 ACVRLK-4 recombinant recombinant-proteins proteins protein

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