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顶部生物活性储存和溶解信息计算器

Anti-KDEL Antibody (8Y233)

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Anti-KDEL Antibody (8Y233)
产品编号 TMAC-02300
别名 Putative MAPK-activating protein PM23, Kdelr1, KDEL receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, ERD21_HUMAN, ERD2.1, ER lumen protein retaining receptor 1

Anti-KDEL Antibody (8Y233) 是一种 Rabbit 抗体，靶向 KDEL。Anti-KDEL Antibody (8Y233) 可用于 WB,ICC,IF,IHC,FCM。

Anti-KDEL Antibody (8Y233)

Anti-KDEL Antibody (8Y233)

Rating icon 还可以
Anti-KDEL Antibody (8Y233)
产品编号 TMAC-02300 别名 Putative MAPK-activating protein PM23, Kdelr1, KDEL receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, ERD21_HUMAN, ERD2.1, ER lumen protein retaining receptor 1

Anti-KDEL Antibody (8Y233) 是一种 Rabbit 抗体，靶向 KDEL。Anti-KDEL Antibody (8Y233) 可用于 WB,ICC,IF,IHC,FCM。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-KDEL Antibody (8Y233) is a Rabbit antibody targeting KDEL. Anti-KDEL Antibody (8Y233) can be used in WB,ICC,IF,IHC,FCM.
别名Putative MAPK-activating protein PM23, Kdelr1, KDEL receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, ERD21_HUMAN, ERD2.1, ER lumen protein retaining receptor 1
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of KDEL on different lysates using anti-KDEL antibody at 1/1,000 dilution. Positive control: Lane 1: Rat testis tissue, Lane 2: Human placenta tissue, Lane 3: Mouse testis tissue, Lane 4: 293.
2. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-KDEL antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti-KDEL antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue using anti-KDEL antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded rat epididymis tissue using anti-KDEL antibody. Counter stained with hematoxylin.
6. ICC staining KDEL in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
7. ICC staining KDEL in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
8. ICC staining KDEL in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
9. Flow cytometric analysis of HepG2 cells with KDEL antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
应用
WB
ICC
IF
IHC
FCM
推荐剂量
WB: 1:500-2000; IHC: 1:100-400; ICC: 1:400-800; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Soluble proteins in the endoplasmic reticulum (ER) contain a specific carboxy terminal sequence KDEL (Lys-Asp-Glu-Leu), and include the coat proteins required for vesicle budding from the ER, proteins that form retrograde vesicles on post-ER compartments, and integral membrane proteins that target vesicles to their correct destination. The retention of these soluble proteins in the ER depends on the interaction of the KDEL sequence with the corresponding KDEL receptor, also designated ERD2, in the Golgi apparatus. When KDEL proteins reach the Golgi complex, they are recognized by the KDEL receptor and transported retrograde in COPI-coated vesicles back to the ER. The small GTPase ADP-ribosylation factor 1 (ARF1), a regulator of vesicle transport, interacts with the KDEL receptor. Subsequently, this interaction allows the KDEL receptor to recruit a GTPase-activating protein (GAP) from the cytosol to membranes, which inactivates ARF1.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P24390
化学信息
分子量Theoretical: 24/17 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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