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Targets Recommended: Apoptosis Apoptosis Caspase

2482

抑制剂 & 化合物

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天然产物

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化合物库

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Cat. No. Product Name
L9000 细胞凋亡化合物库

1796 compounds
1796 种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选;
L1110 微管靶向化合物库

155 compounds
155 种靶向微管的分子集合,用于高通量筛选和高内涵筛选;
L5300 线粒体靶向库

830 compounds
830 种具有潜在或确定线粒体靶向活性的化合物,以促进针对线粒体的药物研究;
L6100 天然多酚类化合物库

640 compounds
640 个天然多酚化合物的独特集合,可用于高通量、高内涵筛选;
L3200 自噬库

1248 compounds
1248 种细胞自噬相关的生物活性小分子化合物的特有集合,用于自噬相关的研究,用于高通量、高内涵筛选;
L1400 MAPK 抑制剂库

367 compounds
367 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合,可用于高通量筛选和高内涵筛选;
L1610 FDA 上市激酶抑制剂库

280 compounds
TargetMol FDA 上市激酶库包含280 个具有明确激酶抑制活性的上市药物
L8600 泛素化化合物库

214 compounds
214 种泛素化相关的小分子,用于高通量和高内涵筛选;
L8700 铁死亡化合物库

800 compounds
800 种与铁死亡通路相关的化合物,可用于高通量和高内涵筛选;
L4100 TGF-β/Smad靶点化合物库

185 compounds
185 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合,用于高通量、高内涵筛选;
L8710 铜死亡化合物库

411 compounds
TargetMol 铜死亡化合物库集合了 411 种与铜死亡相关的化合物,可以用于铜死亡机制及相关疾病研究
L8100 细胞周期化合物库

695 compounds
695 种细胞周期相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
L7900 成骨分子库

320 compounds
320 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
L2140 癌细胞分化化合物库

413 compounds
413 个诱导肿瘤细胞分化化合物的独特集合,可用于高通量筛选和高内涵筛选;
L9700 内质网应激化合物库

193 compounds
193 个内质网应激相关的化合物集合,可用于高通量和高内涵筛选;
L3800 NF-κB 通路分子库

740 compounds
740 个 NF-κB 信号通路相关的小分子化合物的特有集合,用于高通量、高内涵筛选;
L9420 外泌体相关化合物库

80 compounds
80 种外泌体相关的化合物,可以用于高通量和高内涵筛选;
L6810 中药单体化合物库

2688 compounds
2688 种中药来源的单体化合物,是药物开发、药理研究等领域的有力工具;
L6800 中国药典收录天然产物库

2070 compounds
2070 种中国药典收录的天然产物,是药物开发、药理研究等领域的有力工具;
L6740 抗结直肠癌中药单体化合物库

386 compounds
386 种抗结直肠癌相关的中药单体集合,是药物开发、药理研究的有效工具;
L8500 HIF-1化合物库

1352 compounds
1352 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究;

化合物库

细胞凋亡化合物库
Cat.No: L9000
Compounds: 1796
微管靶向化合物库
Cat.No: L1110
Compounds: 155
线粒体靶向库
Cat.No: L5300
Compounds: 830
天然多酚类化合物库
Cat.No: L6100
Compounds: 640
自噬库
Cat.No: L3200
Compounds: 1248
MAPK 抑制剂库
Cat.No: L1400
Compounds: 367
FDA 上市激酶抑制剂库
Cat.No: L1610
Compounds: 280
泛素化化合物库
Cat.No: L8600
Compounds: 214
铁死亡化合物库
Cat.No: L8700
Compounds: 800
TGF-β/Smad靶点化合物库
Cat.No: L4100
Compounds: 185
铜死亡化合物库
Cat.No: L8710
Compounds: 411
细胞周期化合物库
Cat.No: L8100
Compounds: 695
成骨分子库
Cat.No: L7900
Compounds: 320
癌细胞分化化合物库
Cat.No: L2140
Compounds: 413
内质网应激化合物库
Cat.No: L9700
Compounds: 193
NF-κB 通路分子库
Cat.No: L3800
Compounds: 740
外泌体相关化合物库
Cat.No: L9420
Compounds: 80
中药单体化合物库
Cat.No: L6810
Compounds: 2688
中国药典收录天然产物库
Cat.No: L6800
Compounds: 2070
抗结直肠癌中药单体化合物库
Cat.No: L6740
Compounds: 386
HIF-1化合物库
Cat.No: L8500
Compounds: 1352
Cat. No. Product Name Target Signaling Pathways
T1772 MDK83190

Apoptosis Activator 2

Apoptosis; Caspase Apoptosis; Proteases/Proteasome
MDK83190 (Apoptosis Activator 2) 是一种细胞凋亡激活剂,可诱导 caspase-3 激活、Apaf-1 寡聚化、PARP 切割和 DNA 片段化。
T3293 Apoptozole

Apoptosis Activator VII

Apoptosis; HSP Apoptosis; Cytoskeletal Signaling; Metabolism
Apoptozole (Apoptosis Activator VII) 是一种Hsc70和Hsp70的 ATPase 结构域抑制剂,可诱导凋亡,Kd 值分别为 0.21 和 0.14 μM。
T30102 Apoptosis inducer 5d

Apoptosis inducer 5D is a new type of inducer that induces cell death by activating the apoptosis of cancer cells.
T74490 Apoptosis inducer 3

Apoptosisinducer 3 (Compound 3) 是一种凋亡 (apoptosis) 诱导因子,可选择性触发细胞凋亡和晚期细胞凋亡。Apoptosisinducer 3 对癌细胞具有毒性。
T74787 Apoptosis inducer 12

Apoptosisinducer 12 (Compound 3z) 是一种通过线粒体途径诱导凋亡 (apoptosis) 的凋亡诱导剂,可用于癌症的研究。
T63232 Apoptosis inducer 6

Apoptosis inducer 6 是一种抗癌剂,具有广谱抗癌活性,能够诱导细胞凋亡 (apoptosis) 触发细胞死亡。
T79252 Apoptosis inducer 13

Reactive Oxygen Species Immunology/Inflammation; Metabolism; NF-κB
Apoptosisinducer 13(Compound Ru4)能够诱导癌细胞进入凋亡并抑制其迁移与侵袭。该化合物能促进NADH向NAD+的转化,同时提升细胞内ROS的水平。
T62399 Apoptosis inducer 10

Apoptosis inducer 10 是一种有效的细胞凋亡诱导剂,具有抗增殖活性。Apoptosis inducer 10 利用线粒体依赖性内源性途径,诱导 HeLa 癌细胞凋亡 (apoptosis)。
T63485 Apoptosis inducer 8

Apoptosis inducer 8 是一种galectin-1 (gal-1)介导的凋亡 (apoptosis) 诱导剂,也是一种PET 显像剂,能够明显减少 gal-1 蛋白水平,可用于全球主要的肺癌的研究。
T78686 Apoptosis inducer 11

Apoptosis Apoptosis
Apoptosisinducer 11(compound 3u)通过线粒体途径引发细胞凋亡。在非霍奇金淋巴瘤细胞系中,该化合物导致G2/M期停滞和S期显著减少。
T74493 Apoptosis inducer 4

Apoptosisinducer 4 (Compound 12b) 是一种具有抗癌活性的细胞凋亡 (apoptosis) 诱导剂。
T4371 CD437

AHPN,O-Desmethyl Adapalene,6-[3-(1-金刚烷基)-4-羟基苯基]-2-萘甲酸,Apoptosis Activator VI

Retinoid Receptor; Autophagy Autophagy; Metabolism
CD437 (AHPN) 是一种特异性视黄酸受体激动剂。
T23189 prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]

Others Others
Prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens] is a peptide with the sequence H2N-Ala-Thr-Gly-Gly-Tyr-Arg-OH, MW= 623.66.
T16754 RIPGBM

Apoptosis Apoptosis
RIPGBM 是一种选择性诱导多形性胶质母细胞瘤癌症的细胞凋亡诱导剂 ,EC50≤500 nM。
T14973 CITCO

Apoptosis; Others Apoptosis; Others
CITCO 是一种咪唑噻唑衍生物,也是一种选择性组成型雄甾烷受体激动剂。它抑制脑肿瘤干细胞的生长和扩增,其 EC50 比孕烷 X 受体为 49 nM
T3445 Importazole

Apoptosis; Others Apoptosis; Others
Importazole 是一种核转运受体 importin-β 小分子抑制剂。
T3953 Salermide

Apoptosis; Sirtuin Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
Salermide 是一种 Sirt1 和 Sirt2 的抑制剂,可诱导强烈的癌症特异性细胞凋亡。
T7150 BTdCPU

Apoptosis; Phosphatase; PERK Apoptosis; Metabolism
BTdCPU 是一种血红素调节的 eIF2α 激酶激活剂,可促进耐药细胞中 eIF2α磷酸化并诱导凋亡。
T16163 MV1

Apoptosis Apoptosis
MV1 是一种 IAP 拮抗剂。 当与 HaloTag 配体结合时,它会导致 HaloTag 融合蛋白的蛋白质敲低。
T5939 Calcium dobesilate

Apoptosis; Others Apoptosis; Others
Calcium dobesilate 具有血管保护特性,部分通过改善 HG 诱导的炎症来保护内皮细胞,用于慢性静脉疾病、糖尿病视网膜病变以及痔疮发作等研究。
T12085 MN58b

Apoptosis; AChR Apoptosis; Neuroscience
MN58b 是一种选择性的胆碱激酶抑制剂,可抑制磷酸胆碱的合成。它通过诱导凋亡来减少细胞生长,具有抗肿瘤活性。
T6623 Oxibendazole

Apoptosis; Parasite Apoptosis; Microbiology/Virology
Oxibendazole 是一种苯并咪唑驱虫药,用于防止马和一些家养宠物的蛔虫、圆线虫、线虫、蛲虫和肺虫感染。。它可诱导细胞凋亡,具有抗癌和抗炎活性。
T6432 Calpeptin

Apoptosis; Cysteine Protease; Proteasome Apoptosis; Proteases/Proteasome; Ubiquitination
Calpeptin 是一种具有细胞穿透性的calpain 抑制剂,也是cathepsin K 抑制剂,其对人血小板 Calpain I 的ID50值为40 nM。
T13689 Ethylene dimethanesulfonate

Apoptosis Apoptosis
Ethylene dimethanesulfonate 是温和的烷基化乙二醇非挥发性甲烷磺酸二酯,对 LC 具有选择性的促凋亡作用。
T19823 Tebufenozide

Apoptosis Apoptosis
Tebufenozide 是一种新型的非甾体蜕皮激素激动剂。它具有细胞毒性, 能诱导 HeLa 细胞和 Tn5B1-4 昆虫细胞凋亡,在防治鳞翅目害虫中发挥重要作用。
T6664 SecinH3

Apoptosis Apoptosis
SecinH3 是cytohesins 的拮抗剂,是选择性细胞粘附素抑制剂。对于hCyh1、hCyh2、mCyh3、hCyh3、果蝇和yGea2-S7的IC50值分别为 5.4 μM、2.4 μM、5.4 μM、5.6 μM、5.6 μM 和 65 μM。
T4048 Monastrol

(±)-Monastrol

Apoptosis; Kinesin Apoptosis; Cytoskeletal Signaling
Monastrol ((±)-Monastrol) 是一种具有高效性和细胞渗透性的有丝分裂驱动蛋白Eg5的抑制剂,IC50值为 14 μM。
T1710 Trolox

Apoptosis; Antioxidant; Ferroptosis; Reactive Oxygen Species Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
Trolox 是一种维生素 E 的类似物,具有强大的抗氧化作用。它还是强大的膜损伤抑制剂。
T7664 Pyroxamide

Apoptosis; HDAC Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
Pyroxamide 是一种组蛋白脱乙酰基酶 1 抑制剂,IC50为 100 nM。 它可以诱导白血病细胞凋亡和细胞周期停滞。
T1876 Kobe0065

Apoptosis; Raf; Ras Apoptosis; GPCR/G Protein; MAPK
Kobe0065 是一种新型 Ras-Raf 相互作用抑制剂,可完全抑制 H-Ras·GTP 与 c-Raf-1 RBD 的结合,Ki 值为 46±13 μM。
T2417 Sal003

Apoptosis; Phosphatase; PERK Apoptosis; Metabolism
Sal003 是 salubrinal 的衍生物,是一种高效特异性的细胞渗透性 eIF2α 磷酸酶抑制剂。
T4302 iCRT3

Apoptosis; Wnt/beta-catenin Apoptosis; Cytoskeletal Signaling; Stem Cells
iCRT3 是一种Wnt 和 β-连环蛋白应答转录抑制剂。
T14982 Clofilium tosylate

Potassium Channel Membrane transporter/Ion channel
Clofilium tosylate 是一种钾通道阻滞剂,可诱导人早幼粒细胞白血病细胞凋亡,具有抗心律失常作用。
T5181 CA-5f

Apoptosis; Autophagy Apoptosis; Autophagy
CA-5f 是晚期巨自噬/自噬抑制剂,通过抑制自噬体-溶酶体融合起作用。它能够增加监控自噬的标记物 LC3B-II 和 SQSTM1 蛋白水平,促进 ROS 的产生,具有抗肿瘤活性。
T14033 3BDO

Apoptosis; mTOR; Autophagy Apoptosis; Autophagy; PI3K/Akt/mTOR signaling
3BDO 是新型的mTOR 激活剂,对自噬有抑制作用。
T10580 BOC-D-FMK

Apoptosis; Caspase Apoptosis; Proteases/Proteasome
Boc-D-FMK 是一种可渗透细胞,不可逆的泛半胱天冬酶抑制剂。它抑制 TNF-α 诱导的细胞凋亡的IC50值为 39 µM。
T3045 Salubrinal

Apoptosis; Phosphatase; PERK; Autophagy; HSV Apoptosis; Autophagy; Metabolism; Microbiology/Virology
Salubrinal 是一种磷酸酶抑制剂 ,对真核翻译起始因子 2 亚基 (eIF2α) 发挥作用。它作为双特异性磷酸酶 2 抑制剂,抑制抗胶原蛋白抗体诱导的关节炎。它具有抗HSV-1病毒的活性,并抑制由HSV-1蛋白 ICP34.5 介导的eIF2α的去磷酸化。
T3952 TPEN

TPEDA

Apoptosis; Reactive Oxygen Species; Autophagy Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
TPEN (TPEDA) 是一种特定的细胞可渗透的重金属螯合剂,对 Zn2+具有高亲和力,但对 Mg2+和 Ca2+具有较低的亲和力。它诱导 DNA 损伤并增加细胞内ROS 的产生,还抑制细胞增殖并诱导凋亡。
T16680 PTC-028

Apoptosis; BMI-1 Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
PTC-028 是一种口服有效的干细胞因子 BMI-1的抑制剂,可下调 BMI-1,诱导 caspase 介导的细胞凋亡。它选择性地抑制癌细胞,可用于治疗卵巢癌。
T3106 C-DIM12

Apoptosis; Others Apoptosis; Others
C-DIM12是一种人工合成的Nurr1激活剂,可诱导Nurr1和DA 基因表达。
T19777 ODQ

Apoptosis; Others; Guanylate cyclase Apoptosis; GPCR/G Protein; Others
ODQ 是一种选择性可溶性的鸟苷酰环化酶抑制剂,可增强顺铂促人间皮瘤细胞凋亡的作用。
T9582 CLEFMA

NF-κB NF-κB
CLEFMA 是一种姜黄素,抑制肿瘤生长与 NF-κB 调节的抗炎和抗转移作用有关,具有抗肿瘤活性。
T6691 TAI-1

Apoptosis; Microtubule Associated Apoptosis; Cytoskeletal Signaling
TAI1 是一种具有口服活性的特异性 Hec1 抑制剂,有抗肿瘤活性,在 K562 细胞中的 GI50值为 13.48 nM。
T6180 INH6

Apoptosis; Microtubule Associated Apoptosis; Cytoskeletal Signaling
INH6 是一种有效的 Hec1 抑制剂,可选择性地破坏 Hec1/Nek2 相互作用并诱导染色体错位。它抑制HeLa 细胞生长的IC50值为2.4 μM。
T7398 ONC212

Apoptosis; GPR Apoptosis; Endocrinology/Hormones; GPCR/G Protein
ONC212 是氟化 ONC201 类似物,是有前景的抗癌剂。它也是 GPR132的选择性激动剂,可诱导凋亡。
T5130 dBET6

Apoptosis; Epigenetic Reader Domain Apoptosis; Chromatin/Epigenetic
dBET6 是一种基于 PROTAC 的选择性和细胞渗透性 BET 降解剂,IC50值为 14 nM。 它具有抗肿瘤活性。
T7078 NSC 95397

Apoptosis; Phosphatase Apoptosis; Metabolism
NSC 95397 是一种选择性的Cdc25双特异性磷酸酶抑制剂。它抑制丝裂原活化蛋白激酶磷酸酶-1(MKP-1),通过 MKP-1 和 ERK1/2 途径抑制结肠癌细胞的增殖并诱导细胞凋亡。
T16932 SRT 2183

Apoptosis; Sirtuin Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
SRT 2183 是一种选择性Sirtuin-1激活剂,其EC1.5值为 0.36 μM。它诱导生长停滞和凋亡,同时伴随 STAT3 和 NF-κB 去乙酰化,并降低 c-Myc 蛋白水平。
T2039 GSK-923295

Apoptosis; Kinesin Apoptosis; Cytoskeletal Signaling
GSK923295 是一种特异性的变构着丝粒相关蛋白-E 驱动蛋白 ATPase 活性抑制剂,作用于人类和犬类此酶,Ki 分别为 3.2±0.2 nM 和 1.6±0.1 nM。
T9625 Sandalore

Apoptosis Apoptosis
Sandalore 通过减少细胞凋亡和增加外根鞘中延长生长期的生长因子 IGF-1 的产生来延长人类头发的生长。 Sandalore 是嗅觉受体 OR2AT4 的选择性激动剂。

化合物

MDK83190
Cat.No: T1772
Synonym: Apoptosis Activator 2
Target: Apoptosis, Caspase
Apoptozole
Cat.No: T3293
Synonym: Apoptosis Activator VII
Target: Apoptosis, HSP
Apoptosis inducer 5d
Cat.No: T30102
Synonym:
Target:
Apoptosis inducer 3
Cat.No: T74490
Synonym:
Target:
Apoptosis inducer 12
Cat.No: T74787
Synonym:
Target:
Apoptosis inducer 6
Cat.No: T63232
Synonym:
Target:
Apoptosis inducer 13
Cat.No: T79252
Synonym:
Target: Reactive Oxygen Species
Apoptosis inducer 10
Cat.No: T62399
Synonym:
Target:
Apoptosis inducer 8
Cat.No: T63485
Synonym:
Target:
Apoptosis inducer 11
Cat.No: T78686
Synonym:
Target: Apoptosis
Apoptosis inducer 4
Cat.No: T74493
Synonym:
Target:
CD437
Cat.No: T4371
Synonym: AHPN,O-Desmethyl Adapalene,6-[3-(1-金刚烷基)-4-羟基苯基]-2-萘甲酸,Apoptosis Activator VI
Target: Retinoid Receptor, Autophagy
prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]
Cat.No: T23189
Synonym:
Target: Others
RIPGBM
Cat.No: T16754
Synonym:
Target: Apoptosis
CITCO
Cat.No: T14973
Synonym:
Target: Apoptosis, Others
Importazole
Cat.No: T3445
Synonym:
Target: Apoptosis, Others
Salermide
Cat.No: T3953
Synonym:
Target: Apoptosis, Sirtuin
BTdCPU
Cat.No: T7150
Synonym:
Target: Apoptosis, Phosphatase, PERK
MV1
Cat.No: T16163
Synonym:
Target: Apoptosis
Calcium dobesilate
Cat.No: T5939
Synonym:
Target: Apoptosis, Others
MN58b
Cat.No: T12085
Synonym:
Target: Apoptosis, AChR
Oxibendazole
Cat.No: T6623
Synonym:
Target: Apoptosis, Parasite
Calpeptin
Cat.No: T6432
Synonym:
Target: Apoptosis, Cysteine Protease, Proteasome
Ethylene dimethanesulfonate
Cat.No: T13689
Synonym:
Target: Apoptosis
Tebufenozide
Cat.No: T19823
Synonym:
Target: Apoptosis
SecinH3
Cat.No: T6664
Synonym:
Target: Apoptosis
Monastrol
Cat.No: T4048
Synonym: (±)-Monastrol
Target: Apoptosis, Kinesin
Trolox
Cat.No: T1710
Synonym:
Target: Apoptosis, Antioxidant, Ferroptosis, Reactive Oxygen Species
Pyroxamide
Cat.No: T7664
Synonym:
Target: Apoptosis, HDAC
Kobe0065
Cat.No: T1876
Synonym:
Target: Apoptosis, Raf, Ras
Sal003
Cat.No: T2417
Synonym:
Target: Apoptosis, Phosphatase, PERK
iCRT3
Cat.No: T4302
Synonym:
Target: Apoptosis, Wnt/beta-catenin
Clofilium tosylate
Cat.No: T14982
Synonym:
Target: Potassium Channel
CA-5f
Cat.No: T5181
Synonym:
Target: Apoptosis, Autophagy
3BDO
Cat.No: T14033
Synonym:
Target: Apoptosis, mTOR, Autophagy
BOC-D-FMK
Cat.No: T10580
Synonym:
Target: Apoptosis, Caspase
Salubrinal
Cat.No: T3045
Synonym:
Target: Apoptosis, Phosphatase, PERK, Autophagy, HSV
TPEN
Cat.No: T3952
Synonym: TPEDA
Target: Apoptosis, Reactive Oxygen Species, Autophagy
PTC-028
Cat.No: T16680
Synonym:
Target: Apoptosis, BMI-1
C-DIM12
Cat.No: T3106
Synonym:
Target: Apoptosis, Others
ODQ
Cat.No: T19777
Synonym:
Target: Apoptosis, Others, Guanylate cyclase
CLEFMA
Cat.No: T9582
Synonym:
Target: NF-κB
TAI-1
Cat.No: T6691
Synonym:
Target: Apoptosis, Microtubule Associated
INH6
Cat.No: T6180
Synonym:
Target: Apoptosis, Microtubule Associated
ONC212
Cat.No: T7398
Synonym:
Target: Apoptosis, GPR
dBET6
Cat.No: T5130
Synonym:
Target: Apoptosis, Epigenetic Reader Domain
NSC 95397
Cat.No: T7078
Synonym:
Target: Apoptosis, Phosphatase
SRT 2183
Cat.No: T16932
Synonym:
Target: Apoptosis, Sirtuin
GSK-923295
Cat.No: T2039
Synonym:
Target: Apoptosis, Kinesin
Sandalore
Cat.No: T9625
Synonym:
Target: Apoptosis
Cat. No. Product Name Target Signaling Pathways
T72509 Apoptosis inducer 5

Apoptosisinducer 5 是一种木脂素对映异构体,存在于Crataegus pinnatifida 中。Apoptosisinducer 5 通过 Hep3B 细胞中的凋亡和自噬表现出细胞毒性作用。
T3390 Obacunone

Apoptosis; Aromatase; p38 MAPK Apoptosis; Endocrinology/Hormones; MAPK
Obacunone 是从沼泽白葡萄柚种子中分离得到的,通过诱导凋亡发挥抗癌作用。它在雄激素依赖性人前列腺 Y 细胞中具有细胞毒性。它对鼠伤寒沙门氏菌具有抗毒作用,可作为开发鼠伤寒沙门氏菌抗毒策略的先导化合物。
T10619 Bromelain

Apoptosis; Others Apoptosis; Others
Bromelain 是来源于菠萝茎的一种抗炎药,可诱导细胞凋亡,具有纤维蛋白溶解、抗癌、抗水肿和抗血栓形成活性。它通过下调血浆激肽原,抑制前列腺素 E2 表达,降解晚期糖基化终产物受体,在COX 途径上游发生抗氧化作用以及调节血管生成生物标志物而发挥作用。
TN1038 Galgravin

Apoptosis Apoptosis
Galgravin 是望春花中的一种天然产物,具有抗炎和体外细胞毒活性,能诱导白血病细胞凋亡。
TN1065 Hirsutine

Apoptosis Apoptosis
Hirsutine 是一种来自钩藤的吲哚生物碱,可诱导细胞凋亡,是一种登革热病毒抑制剂,且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。
T5793 Britannin

Apoptosis; AMPK; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Britannin 是分离于旋覆花的一种倍半萜内酯,可通过激活由 ROS 调节的 AMPK 来诱导肝癌细胞凋亡和自噬,具有抗增殖和抗炎活性。
T5S1287 Ligustilide

Apoptosis; Autophagy Apoptosis; Autophagy
Ligustilide 是从当归和川芎中分离出来的一种生物活性邻苯二甲酸酯衍生物,具有神经保护、抗癌、抗炎和血管扩张作用。
T5776 pimpinellin

Apoptosis; Anti-infection Apoptosis; Microbiology/Virology
Pimpinellin 是贯众的一种成分,可通过诱导肿瘤细胞凋亡抑制肿瘤细胞的生长,可作为具有 GABA 受体活性的蛋白质的拮抗剂。
T5S1897 Linderalactone

Apoptosis; Others; JAK Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
Linderalactone 是从乌药中分离出来的一种倍半萜烯内酯,通过调节凋亡相关蛋白的表达和抑制 JAK/STAT 信号通路来抑制癌细胞生长。它以 IC50值为 15 µM 来抑制肺癌 A-549 细胞的增殖。
T6S1652 Benzoylpaeoniflorin

COX Immunology/Inflammation; Neuroscience
Benzoylpaeoniflorin 是一种从白芍中提取的天然化合物,可以降低细胞凋亡,对冠心病具有潜在的研究价值。
T8297 Gomisin N

Apoptosis Apoptosis
Gomisin N 是从五味子中分离得到的一种天然产物,有镇静和催眠生物活性。它具有用于治疗过敏和抑制癌症增殖和诱导细胞凋亡的潜力。
TN1421 Bacopaside II

Apoptosis Apoptosis
Bacopaside II 是药用植物Bacopa monnieri 的提取物,可阻断Aquaporin-1 (AQP1)水通道并阻碍表达 AQP1 的细胞迁移,还诱导细胞周期停滞和细胞凋亡。
T8852 tubuloside B

Apoptosis; Others Apoptosis; Others
Tubuloside B 是可从管花肉苁蓉茎中分离出的一种天然产物,具有抗氧化活性,可抑制TNFα 诱导的细胞凋亡。
TN1586 Dihydrorotenone

Apoptosis; Mitochondrial Metabolism Apoptosis; Metabolism
Dihydrorotenone 是一种线粒体抑制剂,是天然杀虫剂。它通过触发内质网应激并激活 p38 信号通路来诱导人浆细胞凋亡,可能诱发帕金森综合症。
T2S0886 Terrestrosin D

Apoptosis; Others Apoptosis; Others
Terrestrosin D 是从刺蒺藜中提取得到一种的甾体皂苷,可诱导细胞周期阻滞和癌细胞凋亡,具有抗血管生成的活性。
T5S0543 Isocurcumenol

Apoptosis; Estrogen Receptor/ERR; Reductase Apoptosis; Endocrinology/Hormones; Metabolism
Isocurcumenol 是从莪术中分离得到的一种天然产物,是一种ERα抑制剂,对 DLA 和 KB 癌细胞的IC50分别为 99.1 µg/mL 和 178.2 µg/mL,具有抗肿瘤活性。
T6S2315 Polyphyllin VI

Apoptosis; Antibacterial; Pyroptosis Apoptosis; Immunology/Inflammation; Microbiology/Virology
Polyphyllin VI 是一种活性皂甙,诱导 G2/M 细胞周期停滞并引发细胞凋亡,具有抗癌活性。它通过诱导非小细胞肺癌中的 ROS/NF-κB/NLRP3/GSDMD 信号轴来诱导 caspase-1 介导的细胞焦亡。
T8057 Citronellyl acetate

Apoptosis; Others Apoptosis; Others
Citronellyl acetate 是一种植物次生代谢产物,具有杀菌、杀幼虫、杀菌和驱虫杀虫作用,以及抗伤害活性。它在人肝癌细胞中具有促凋亡活性。
T5607 Geranyl acetate

Apoptosis; Others Apoptosis; Others
Geranyl acetate 是一种由香叶醇衍生而来的无环单萜烯酯,可诱导细胞凋亡。它具有香味,被广泛用于化妆品行业。
T4957 Carnosic acid

Apoptosis; ROS; Antibacterial Apoptosis; Immunology/Inflammation; Microbiology/Virology
Carnosic acid 抑制细胞增殖,有抗菌、抗炎和抗氧化应激作用。
TN2091 Polygalacin D

Apoptosis; IAP Apoptosis
Polygalacin D 是从桔梗中分离的一种天然产物,具有抗癌和抗增殖特性。它通过 PI3K/Akt 途径诱导凋亡。它抑制 IAP 蛋白家族的表达,并通过抑制 GSK3β,Akt 的磷酸化和 PI3K 的表达来阻断 PI3K/Akt 途径。
TN1658 Ganoderenic acid D

Apoptosis; Others Apoptosis; Others
Ganoderenic acid D 是从灵芝提取物 (GLE) 的有效化合物中分离出来的天然产物。 Ganoderenic acid D 诱导细胞周期停滞和细胞凋亡并抑制癌细胞的增殖。
T13815 Penicillic acid

Apoptosis; Caspase; Antibacterial; Antibiotic Apoptosis; Microbiology/Virology; Proteases/Proteasome
Penicillic acid, a polyketide mycotoxin, synthesized by various species of Aspergillus and Penicillium, acts as an inhibitor of Fas ligand-induced apoptosis by impeding self-processing of caspase-8. Additionally, in vitro studies have shown that Penicillic acid displays cytotoxic properties in rat alveolar macrophages.
T6S2038 Ziyuglycoside II

Apoptosis; Antioxidant; Reactive Oxygen Species Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
Ziyuglycoside II 是从地榆中提取的一种三萜皂苷,可诱导活性氧 产生和凋亡,具有抗炎和抗癌作用。
T2S2215 Crebanine

Apoptosis; Others; Akt Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
S00015 Tea polyphenol

Apoptosis; Others; Autophagy Apoptosis; Autophagy; Others
Tea polyphenol 也称为绿茶提取物,是茶中天然存在的酚类化合物,具有抗癌、抗氧化、抑制细胞增殖、诱导细胞凋亡、延缓细胞周期和调节致癌物代谢等生物活性。
T4S0536 Bullatine A

Apoptosis; P2X Receptor Apoptosis; Membrane transporter/Ion channel; Neuroscience
Bullatine A 是一种有效的 P2X7拮抗剂,可抑制 ATP 诱导的细胞凋亡和 P2X 受体介导的炎症反应。它是乌头属的二萜生物碱,能缓解过敏反应,具有抗风湿、抗炎和抗伤害作用,可用于治疗关节炎等神经退行性疾病。
TN1918 Medicarpin

美迪紫檀素

Apoptosis; BCL; ROS; JNK Apoptosis; Immunology/Inflammation; MAPK
Medicarpin 是从紫花苜蓿中分离出的一种类黄酮。它通过调节 P-gp 介导的药物外流,诱导白血病 P388 细胞凋亡并克服多药耐药性。
T2866 Echinocystic acid

Apoptosis; Antioxidant; Reactive Oxygen Species Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
Echinocystic acid 是从皂角的果实中提取出来的一种五环三萜,有抗氧化,抗炎症和抗肿瘤作用。
T4951 kauran-16,17-diol

Apoptosis; Others Apoptosis; Others
Kauran-16,17-diol 是一个天然的二萜天然产物,抑制 LPS 诱导的RAW 264.7 细胞产生 NO 的IC50值为17 μM,具有抗肿瘤诱导凋亡的活性。
T6377 Aloperine

Apoptosis; Virus Protease; HIV Protease; Antibiotic; Autophagy Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome
Aloperine 是一种在苦参类植物中的生物碱,其具有抗癌,抗炎、抗肿瘤和抗病毒特性,可用于研究过敏性接触性皮炎湿疹和其他皮肤炎症。
T7177 Capsazepine

Apoptosis; TRP/TRPV Channel Apoptosis; Membrane transporter/Ion channel
Capsazepine 是一种 TRPV1 受体的拮抗剂, IC50值为 562 nM。 它可阻断由激活 TRPV1 离子通道的辣椒素引起的热痛感,是辣椒素拮抗剂。
TN1620 Eriocalyxin B

毛萼乙素

Apoptosis; cAMP; NF-κB; STAT Apoptosis; GPCR/G Protein; JAK/STAT signaling; NF-κB; Stem Cells
Eriocalyxin B 是从中草药枇杷素中分离得到的一种二萜类天然产物,可诱导细胞凋亡,具有抗癌和抗炎作用。
T3824 Jaceosidin

Apoptosis; BCL; COX; UGT Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。
T2565 Hesperetin

橙皮素

Apoptosis; p38 MAPK; 5-HT Receptor; Autophagy; TGF-beta/Smad Apoptosis; Autophagy; GPCR/G Protein; MAPK; Neuroscience; Stem Cells
Hesperetin 是一种天然黄烷酮类物质,是人UGT 的广谱抑制剂,可诱导凋亡。
TMS1743 Salvigenin

MAO; Autophagy; ROS Kinase Autophagy; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
Salvigenin 是从鼠尾草中发现的一种多酚类天然产物,具有神经保护、抗肿瘤、免疫调节和细胞毒作用。
T5S1103 Isoliensinine

异莲心碱,Isoliensinin

Apoptosis; Antioxidant Apoptosis; oxidation-reduction
Isoliensinine (Isoliensinin) 是从水芙蓉种子胚中提取的一种双苄基异喹啉生物碱,能诱导三阴性乳腺癌细胞凋亡,具有抗氧化、抗炎、抗癌活性。
TN1675 Gardenin B

栀子黄素B

Apoptosis; ROS; Caspase; NO Synthase Apoptosis; Immunology/Inflammation; Proteases/Proteasome
Gardenin B 是从Baccharis scandens 中分离出的一种黄酮类天然产物。它对肺、乳腺、结肠、肝和白血病细胞系以及角质形成细胞具有优异的抗增殖活性。
T2S1040 Jolkinolide B

ERK; IL Receptor; BCL; p38 MAPK; TNF; NF-κB; Akt; Caspase; PI3K; JAK; JNK; STAT; mTOR Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
Jolkinolide B 是一种从 Euphorbia fischeriana Steud 的根中分离出来的具有生物活性的二萜。 Jolkinolide B 诱导癌细胞凋亡。 Jolkinolide B 可用于预防和治疗骨溶解的研究。
T9144 Telekin

Others Others
Telekin 是一种从中草药 Carpesium divaricatum 中分离出来的 eudesmane 型倍半萜内酯化合物,据报道可强烈抑制癌细胞的增殖。
TN1121 Evocarpine

Apoptosis; cAMP; Anti-infection; Calcium Channel; Antibacterial Apoptosis; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
Evocarpine 是从 Evodiae fructus 分离得到的一种喹诺酮类生物碱,有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。
TN1417 Azadirachtin

Apoptosis; Antifection Apoptosis; Microbiology/Virology
Azadirachtin 是一种有前途的植物源杀虫剂,能够诱导昆虫 Sf9、SL-1 和 BTI-Tn-5B1-4 细胞凋亡。它广泛用于害虫防治。
TN5888 Toddaculin

Others Others
Toddaculin 是一种天然香豆素,抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡,具有抗炎活性。
T5S1952 9-Methoxycamptothecin

Apoptosis; Topoisomerase Apoptosis; DNA Damage/DNA Repair
9-Methoxycamptothecin 是从臭味假柴龙树中分离得到的一种天然产物,通过抑制拓扑异构酶起到抗肿瘤作用,具有强效的诱导 G2/M 期细胞和癌细胞凋亡的作用。
T2759 Loganin

Loganoside,马钱子苷

Apoptosis; NF-κB; BACE; AChR; AChE Apoptosis; Neuroscience; NF-κB
Loganin (Loganoside) 是山茱萸中的主要环烯醚萜苷类天然产物,具有抗炎、抗休克的作用。
TN1891 Lupiwighteone

Apoptosis; BCL; PARP; Caspase Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
Lupiwighteone 是一种广泛存在于野生植物中的异黄酮。它通过抑制 PI3K/Akt/mTOR 通路,诱导人乳腺癌细胞 caspase 依赖性和非依赖性凋亡,具有抗氧化、抗菌和抗癌作用。
T4672 Brevilin A

Apoptosis; Anti-infection; JAK; STAT; Autophagy Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells
Brevilin A 是从Centipeda minima 中分离的倍半萜内酯,具有抗癌活性。它通过线粒体途径和 PI3K/AKT/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。它是一种选择性JAK-STAT 信号通路抑制剂,通过减弱 JAK 信号和 阻塞 STAT3 信号起作用。
T7190 Actein

Apoptosis; Akt; JNK; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
Actein 是从升麻的根茎中分离的一种三萜糖苷,通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖,诱导自噬和凋亡。
T6S0325 Glycitein

黄豆黄素,Glycetein

Apoptosis; Others Apoptosis; Others
Glycitein (Glycetein) 是一种大豆异黄酮,可研究抗氧化和细胞凋亡。
TQ0207 Sulforaphane

萝卜硫素

Apoptosis; Nrf2; HDAC Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation
Sulforaphane 是存在于多种蔬菜中的一种天然异硫氰酸酯。它可以激活Nrf2,并通过 AMPK 依赖性信号传导抑制高糖诱导的胰腺癌。它增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性,具有抗癌和抗炎活性。
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天然产物

Apoptosis inducer 5
Cat.No: T72509
Synonym:
Target:
Obacunone
Cat.No: T3390
Synonym:
Target: Apoptosis, Aromatase, p38 MAPK
Bromelain
Cat.No: T10619
Synonym:
Target: Apoptosis, Others
Galgravin
Cat.No: TN1038
Synonym:
Target: Apoptosis
Hirsutine
Cat.No: TN1065
Synonym:
Target: Apoptosis
Britannin
Cat.No: T5793
Synonym:
Target: Apoptosis, AMPK, Autophagy
Ligustilide
Cat.No: T5S1287
Synonym:
Target: Apoptosis, Autophagy
pimpinellin
Cat.No: T5776
Synonym:
Target: Apoptosis, Anti-infection
Linderalactone
Cat.No: T5S1897
Synonym:
Target: Apoptosis, Others, JAK
Benzoylpaeoniflorin
Cat.No: T6S1652
Synonym:
Target: COX
Gomisin N
Cat.No: T8297
Synonym:
Target: Apoptosis
Bacopaside II
Cat.No: TN1421
Synonym:
Target: Apoptosis
tubuloside B
Cat.No: T8852
Synonym:
Target: Apoptosis, Others
Dihydrorotenone
Cat.No: TN1586
Synonym:
Target: Apoptosis, Mitochondrial Metabolism
Terrestrosin D
Cat.No: T2S0886
Synonym:
Target: Apoptosis, Others
Isocurcumenol
Cat.No: T5S0543
Synonym:
Target: Apoptosis, Estrogen Receptor/ERR, Reductase
Polyphyllin VI
Cat.No: T6S2315
Synonym:
Target: Apoptosis, Antibacterial, Pyroptosis
Citronellyl acetate
Cat.No: T8057
Synonym:
Target: Apoptosis, Others
Geranyl acetate
Cat.No: T5607
Synonym:
Target: Apoptosis, Others
Carnosic acid
Cat.No: T4957
Synonym:
Target: Apoptosis, ROS, Antibacterial
Polygalacin D
Cat.No: TN2091
Synonym:
Target: Apoptosis, IAP
Ganoderenic acid D
Cat.No: TN1658
Synonym:
Target: Apoptosis, Others
Penicillic acid
Cat.No: T13815
Synonym:
Target: Apoptosis, Caspase, Antibacterial, Antibiotic
Ziyuglycoside II
Cat.No: T6S2038
Synonym:
Target: Apoptosis, Antioxidant, Reactive Oxygen Species
Crebanine
Cat.No: T2S2215
Synonym:
Target: Apoptosis, Others, Akt
Tea polyphenol
Cat.No: S00015
Synonym:
Target: Apoptosis, Others, Autophagy
Bullatine A
Cat.No: T4S0536
Synonym:
Target: Apoptosis, P2X Receptor
Medicarpin
Cat.No: TN1918
Synonym: 美迪紫檀素
Target: Apoptosis, BCL, ROS, JNK
Echinocystic acid
Cat.No: T2866
Synonym:
Target: Apoptosis, Antioxidant, Reactive Oxygen Species
kauran-16,17-diol
Cat.No: T4951
Synonym:
Target: Apoptosis, Others
Aloperine
Cat.No: T6377
Synonym:
Target: Apoptosis, Virus Protease, HIV Protease, Antibiotic, Autophagy
Capsazepine
Cat.No: T7177
Synonym:
Target: Apoptosis, TRP/TRPV Channel
Eriocalyxin B
Cat.No: TN1620
Synonym: 毛萼乙素
Target: Apoptosis, cAMP, NF-κB, STAT
Jaceosidin
Cat.No: T3824
Synonym:
Target: Apoptosis, BCL, COX, UGT
Hesperetin
Cat.No: T2565
Synonym: 橙皮素
Target: Apoptosis, p38 MAPK, 5-HT Receptor, Autophagy, TGF-beta/Smad
Salvigenin
Cat.No: TMS1743
Synonym:
Target: MAO, Autophagy, ROS Kinase
Isoliensinine
Cat.No: T5S1103
Synonym: 异莲心碱,Isoliensinin
Target: Apoptosis, Antioxidant
Gardenin B
Cat.No: TN1675
Synonym: 栀子黄素B
Target: Apoptosis, ROS, Caspase, NO Synthase
Jolkinolide B
Cat.No: T2S1040
Synonym:
Target: ERK, IL Receptor, BCL, p38 MAPK, TNF, NF-κB, Akt, Caspase, PI3K, JAK, JNK, STAT, mTOR
Telekin
Cat.No: T9144
Synonym:
Target: Others
Evocarpine
Cat.No: TN1121
Synonym:
Target: Apoptosis, cAMP, Anti-infection, Calcium Channel, Antibacterial
Azadirachtin
Cat.No: TN1417
Synonym:
Target: Apoptosis, Antifection
Toddaculin
Cat.No: TN5888
Synonym:
Target: Others
9-Methoxycamptothecin
Cat.No: T5S1952
Synonym:
Target: Apoptosis, Topoisomerase
Loganin
Cat.No: T2759
Synonym: Loganoside,马钱子苷
Target: Apoptosis, NF-κB, BACE, AChR, AChE
Lupiwighteone
Cat.No: TN1891
Synonym:
Target: Apoptosis, BCL, PARP, Caspase
Brevilin A
Cat.No: T4672
Synonym:
Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy
Actein
Cat.No: T7190
Synonym:
Target: Apoptosis, Akt, JNK, Autophagy
Glycitein
Cat.No: T6S0325
Synonym: 黄豆黄素,Glycetein
Target: Apoptosis, Others
Sulforaphane
Cat.No: TQ0207
Synonym: 萝卜硫素
Target: Apoptosis, Nrf2, HDAC
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Cat. No. Product Name Species Expression System
TMPY-01824 Caspase-14 Protein, Human, Recombinant (His)

caspase 14, apoptosis-related cysteine peptidase,AR...

Human E. coli
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Casp...
TMPY-03974 Bim Protein, Human, Recombinant (His)

BAM,BCL2-like 11 (apoptosis facilitator),BIM,BOD

Human E. coli
BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymoc...
TMPJ-01329 ATG5 Protein, Human, Recombinant

ASP,APG5L,Apoptosis-specific protein,Autophagy prot...

Human E. coli
ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic cells. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 plays an impor...
TMPJ-01192 ELAPOR1 Protein, Human, Recombinant (His)

ELAPOR1,Endosome-Lysosome Associated Apoptosis And ...

Human Human Cells
Endosome/lysosome-associated apoptosis and autophagy regulator (ELAPOR1), also known as EIG121 protein, is a type I transmembrane protein induced by estrogen. The estrogen-induced gene 121 (EIG121) has been associated with breast and endometrial cancers,but its mechanism of action remains unknown.May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. That EIG121 is a good endometrial biomarker associated with a hyperestrogenic state and estr...
TMPJ-00718 AIF Protein, Human, Recombinant (His)

AIF,Apoptosis-Inducing Factor 1 Mitochondrial,PDCD8...

Human E. coli
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces pa...
TMPJ-00584 Bc1-w Protein, Human, Recombinant (His)

Apoptosis Regulator Bcl-W,KIAA0271,Bcl-2-Like Prote...

Human E. coli
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone...
TMPY-02831 Caspase-7 Protein, Human, Recombinant (His)

ICE-LAP3,LICE2,MCH3,CASP-7,caspase 7, apoptosis-rel...

Human E. coli
Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are r...
TMPJ-00696 NOL3 Protein, Human, Recombinant

Apoptosis Repressor With CARD,Nucleolar Protein of ...

Human E. coli
Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex ...
TMPJ-00661 PDCD5 Protein, Human, Recombinant (His)

Programmed Cell Death Protein 5,Protein TFAR19,TFAR19,PDCD5,...

Human E. coli
Programmed Cell Death Protein 5 (PDCD5) is a member of the PDCD5 family. PDCD5 is expressed in tumor cells during apoptosis, independent of apoptosis-inducing stimuli. This protein may function in the process of apoptosis. PDCD5 is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 may play an important regulator of K (lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its pr...
TMPJ-00215 Fas/CD95 Protein, Mouse, Recombinant (hFc)

CD95,Apoptosis-mediating surface antigen FAS,TNFRSF...

Mouse Human Cells
Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which...
TMPJ-00655 TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His)

TRAIL-R1,TNFRSF10A,cytotoxic TRAIL receptor,APO2,CD261 antig...

Human Human Cells
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF...
TMPJ-00697 NOL3 Protein, Human, Recombinant (GST)

Nop30,Myp,NOP,Apoptosis Repressor With CARD,Nucleol...

Human E. coli
Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing.Isoform 2 may inhibit apoptosis.It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.
TMPJ-01300 PDCD10 Protein, Human, Recombinant

TFAR15,Programmed Cell Death Protein 10,PDCD10,TF-1 Cell

Human E. coli
Programmed Cell Death Protein 10 (PDCD10) belongs to the PDCD10 family. PDCD10 exists as a homodimer and is widely expressed. PDCD10 can increase mitogen-activated protein kinase activity and MST4 activity. PDCD10 is required for normal cardiovascular development and normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3.
TMPY-01216 XIAP Protein, Human, Recombinant (Avi)

hIAP-3,IAP-3,MIHA,ILP1,BIRC4,hIAP3,API3,XLP2,X-linked inhibi...

Human E. coli
E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced ...
TMPJ-00368 PCSK9 Protein, Human, Recombinant (Avi), Biotinylated

Subtilisin/Kexin-Like Protease PC9,PC9,NARC-1,Proprotein Con...

Human Human Cells
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interacti...
TMPY-02922 XIAP Protein, Human, Recombinant (His)

hIAP-3,API3,XLP2,ILP1,MIHA,X-linked inhibitor of apoptos...

Human E. coli
E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced ...
TMPJ-00369 PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated

Subtilisin/Kexin-Like Protease PC9,PCSK9,NARC1,Proprotein Co...

Human Human Cells
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interacti...
TMPJ-00275 TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated

DR5,Tumor Necrosis Factor Receptor Superfamily Member 10B,TR...

Human Human Cells
TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass ...
TMPJ-00430 TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His)

Death Receptor 5,TRAILR2,CD262,DR5,TNFRSF10B,TRAIL-R2,ZTNFR9...

Cynomolgus Human Cells
TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass ...
TMPJ-00276 TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His)

DR5,TRAILR2,TRICK2,TNFRSF10B,KILLER,TNF-Related Apoptosi...

Human Human Cells
TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass ...
TMPJ-00418 TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His)

Decoy Receptor 1,Antagonist Decoy Receptor for TRAIL/Apo-2L,...

Human Human Cells
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
TMPY-03956 Fas Ligand Protein, Human, Recombinant (His)

TNLG1A,FASL,FASLG,CD178,CD95-L,APT1LG1,APTL,CD95L,Fas ligand...

Human Yeast
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
TMPY-01185 DR5/TRAIL R2 Protein, Human, Recombinant (His)

KILLER,TRICK2A,TRICK2,DR5,TRICKB,tumor necrosis factor recep...

Human HEK293
Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containin...
TMPJ-00994 LTBR Protein, Mouse, Recombinant (hFc)

Tnfcr,Lymphotoxin-beta receptor,Tumor necrosis factor recept...

Mouse Human Cells
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs...
TMPY-02096 TACI Protein, Human, Recombinant (His)

RYZN,IGAD2,CVID,TACI,TNFRSF14B,CVID2,tumor necrosis factor r...

Human HEK293
Tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) also known as Transmembrane activator and CAML interactor (TACI) and CD267 antigen, is a member of the tumor necrosis factor receptor superfamily. TNFRSF13B is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adapt...
TMPY-02431 BCL-XL Protein, Human, Recombinant (His)

bcl-xS,PPP1R52,Bcl-X,BCLXL,BCLX,BCLXS,BCL2-like 1,bcl-xL,BCL...

Human E. coli
B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibit apoptosis. Antiapoptotic members such as Bcl-2 and Bcl-xL prevent PCD in response to a wide variety of stimuli to take part in cancer survival. Conversely, proapoptotic proteins, exemplified by Bax and Bak, can accelerate death and in some instances are sufficient to cause apop...
TMPY-00423 FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc)

BFR-1,KGFR,TK25,JWS,ECT1,K-SAM,FGFR2 α(IIIb),CD332,fibroblas...

Human HEK293
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung mor...
TMPY-00972 FGFR2 Protein, Human, Recombinant (His & hFc)

K-SAM,TK14,BBDS,fibroblast growth factor receptor 2,BFR-1,CD...

Human HEK293
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung mor...
TMPY-03357 FGFR2 Protein, Mouse, Recombinant (hFc)

KGFR,AU043015,KGFRTr,Bek,Fgfr7,svs,fibroblast growth factor ...

Mouse HEK293
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung mor...
TMPY-04632 IL-15 Protein, Human, Recombinant

白细胞介素,IL-15,白介素,interleukin 15

Human E. coli
The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as ...
TMPJ-01468 pro-Beta NGF Protein, Human, Recombinant

β-NGF,NGF,NGFB,Beta-NGF,Beta-Nerve Growth Factor,pro-Beta NG...

Human E.coli
The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
TMPY-01143 N Cadherin Protein, Human, Recombinant (His)

CDHN,CDw325,NCAD,CD325,cadherin 2, type 1, N-cadherin (neuro...

Human HEK293
Cadherins are calcium-dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass transmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development,...
TMPY-04413 IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)

hIRE1p,endoplasmic reticulum to nucleus signaling 1,IRE1P,IR...

Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces...
TMPY-02078 HtrA2/Omi Protein, Human, Recombinant (His)

PARK13,OMI,HtrA serine peptidase 2,PRSS25

Human E. coli
Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor...
TMPY-03235 BST2 Protein, Human, Recombinant (His)

bone marrow stromal cell antigen 2,CD317,TETHERIN

Human HEK293
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demonstrated that knockdown of BST2 by siRNA inhibited cell proliferation, induced apoptosis and repressed cell motility in GC cells. In addition, the pro-tumor function of BST2 in GC was mediated partly through the NF-κB signaling. BST2 possesses the oncogenic potential in GC by regul...
TMPY-06981 IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)

interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细胞介素,IL-1 ...

Human E. coli
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage...
TMPY-04753 IRE1 Protein, Human, Recombinant (aa 465-977)

hIRE1p,endoplasmic reticulum to nucleus signaling 1,IRE1P,IR...

Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces...
TMPY-05039 LTBR Protein, Human, Recombinant (hFc)

TNFR-RP,lymphotoxin β receptor (TNFR superfamily, member 3),...

Human HEK293
LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. The tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymph...
TMPY-01738 IL-1 alpha/IL-1A Protein, Mouse, Recombinant

interleukin 1, α,IL-1 α/IL1A,interleukin 1, alpha,Il-1a

Mouse E. coli
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage...
TMPY-02087 IL-24 Protein, Human, Recombinant (His)

C49A,IL10B,MOB5,ST16,MDA7,FISP,interleukin 24,白细胞介素,白介素

Human HEK293
Interleukin-24 (IL-24) also known as Melanoma differentiation-associated gene 7 protein (MDA-7) is a member of the IL10 family of cytokines. IL-24/MDA-7/IL24 can induce apoptosis selectively in various cancer cells. Overexpression of IL-24 leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this ge...
TMPY-00854 IL-1 alpha/IL-1A Protein, Human, Recombinant

IL-1F1,interleukin 1, α,interleukin 1, alpha,白介素,IL1-ALPHA,白...

Human HEK293
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage...
TMPY-04830 GAS6 Protein, Mouse, Recombinant (His)

growth arrest-specific 6,Gas-6

Mouse HEK293
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor...
TMPY-03101 TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His)

tumor necrosis factor receptor superfamily, member 1b

Cynomolgus,Rhesus HEK293
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this...
TMPY-02700 BCL2 Protein, Human, Recombinant (His)

Bcl-2,PPP1R50,B-cell CLL/lymphoma 2

Human E. coli
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins...
TMPY-01697 TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)

Tnfr-1,TNFR80,TNF-R-II,TNF-αR2,tumor necrosis factor recepto...

Mouse HEK293
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this...
TMPY-01166 TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His)

TNFR80,p75,TNF-R75,TNFR1B,tumor necrosis factor receptor sup...

Human HEK293
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this...
TMPY-03670 PD-L1 Protein, Cynomolgus/Rhesus, Recombinant (His)

CD274 molecule

Cynomolgus,Rhesus HEK293
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 fa...
TMPY-02614 NGFR/p75NTR Protein, Human, Recombinant (hFc)

神经生长因子,nerve growth factor receptor (TNFR superfamily, membe...

Human HEK293
Nerve growth factor receptors (NGFRs) belong to a large growth factor receptor family. NGFR includes two types of receptors: high-affinity nerve growth factor receptor and low-affinity nerve growth factor receptor. The high-affinity nerve growth factor receptor is also referred to as the Trk family whose members are bound by some neurotrophins with high affinity.Nerve growth factorbinds with TrkA after being released from target cells, the NGF / TrkA complex is subsequently trafficked back to th...
TMPY-05208 PD-L1 Protein, Human, Recombinant

CD274 molecule,PDCD1L1,PD-L1,PDL1,PDCD1LG1,B7H1,B7-H,B7-H1

Human HEK293
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 fa...
TMPY-01155 PD-L1 Protein, Mouse, Recombinant (His)

Pdcd1l1,CD274 molecule,B7h1,A530045L16Rik,Pdl1,Pdcd1lg1

Mouse HEK293
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 fa...
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重组蛋白

Caspase-14 Protein, Human, Recombinant (His)
Cat.No: TMPY-01824
Species: Human
Expression System: E. coli
Bim Protein, Human, Recombinant (His)
Cat.No: TMPY-03974
Species: Human
Expression System: E. coli
ATG5 Protein, Human, Recombinant
Cat.No: TMPJ-01329
Species: Human
Expression System: E. coli
ELAPOR1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01192
Species: Human
Expression System: Human Cells
AIF Protein, Human, Recombinant (His)
Cat.No: TMPJ-00718
Species: Human
Expression System: E. coli
Bc1-w Protein, Human, Recombinant (His)
Cat.No: TMPJ-00584
Species: Human
Expression System: E. coli
Caspase-7 Protein, Human, Recombinant (His)
Cat.No: TMPY-02831
Species: Human
Expression System: E. coli
NOL3 Protein, Human, Recombinant
Cat.No: TMPJ-00696
Species: Human
Expression System: E. coli
PDCD5 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00661
Species: Human
Expression System: E. coli
Fas/CD95 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00215
Species: Mouse
Expression System: Human Cells
TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His)
Cat.No: TMPJ-00655
Species: Human
Expression System: Human Cells
NOL3 Protein, Human, Recombinant (GST)
Cat.No: TMPJ-00697
Species: Human
Expression System: E. coli
PDCD10 Protein, Human, Recombinant
Cat.No: TMPJ-01300
Species: Human
Expression System: E. coli
XIAP Protein, Human, Recombinant (Avi)
Cat.No: TMPY-01216
Species: Human
Expression System: E. coli
PCSK9 Protein, Human, Recombinant (Avi), Biotinylated
Cat.No: TMPJ-00368
Species: Human
Expression System: Human Cells
XIAP Protein, Human, Recombinant (His)
Cat.No: TMPY-02922
Species: Human
Expression System: E. coli
PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated
Cat.No: TMPJ-00369
Species: Human
Expression System: Human Cells
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated
Cat.No: TMPJ-00275
Species: Human
Expression System: Human Cells
TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPJ-00430
Species: Cynomolgus
Expression System: Human Cells
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His)
Cat.No: TMPJ-00276
Species: Human
Expression System: Human Cells
TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His)
Cat.No: TMPJ-00418
Species: Human
Expression System: Human Cells
Fas Ligand Protein, Human, Recombinant (His)
Cat.No: TMPY-03956
Species: Human
Expression System: Yeast
DR5/TRAIL R2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01185
Species: Human
Expression System: HEK293
LTBR Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00994
Species: Mouse
Expression System: Human Cells
TACI Protein, Human, Recombinant (His)
Cat.No: TMPY-02096
Species: Human
Expression System: HEK293
BCL-XL Protein, Human, Recombinant (His)
Cat.No: TMPY-02431
Species: Human
Expression System: E. coli
FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc)
Cat.No: TMPY-00423
Species: Human
Expression System: HEK293
FGFR2 Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-00972
Species: Human
Expression System: HEK293
FGFR2 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-03357
Species: Mouse
Expression System: HEK293
IL-15 Protein, Human, Recombinant
Cat.No: TMPY-04632
Species: Human
Expression System: E. coli
pro-Beta NGF Protein, Human, Recombinant
Cat.No: TMPJ-01468
Species: Human
Expression System: E.coli
N Cadherin Protein, Human, Recombinant (His)
Cat.No: TMPY-01143
Species: Human
Expression System: HEK293
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)
Cat.No: TMPY-04413
Species: Human
Expression System: Baculovirus-Insect Cells
HtrA2/Omi Protein, Human, Recombinant (His)
Cat.No: TMPY-02078
Species: Human
Expression System: E. coli
BST2 Protein, Human, Recombinant (His)
Cat.No: TMPY-03235
Species: Human
Expression System: HEK293
IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
Cat.No: TMPY-06981
Species: Human
Expression System: E. coli
IRE1 Protein, Human, Recombinant (aa 465-977)
Cat.No: TMPY-04753
Species: Human
Expression System: Baculovirus-Insect Cells
LTBR Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05039
Species: Human
Expression System: HEK293
IL-1 alpha/IL-1A Protein, Mouse, Recombinant
Cat.No: TMPY-01738
Species: Mouse
Expression System: E. coli
IL-24 Protein, Human, Recombinant (His)
Cat.No: TMPY-02087
Species: Human
Expression System: HEK293
IL-1 alpha/IL-1A Protein, Human, Recombinant
Cat.No: TMPY-00854
Species: Human
Expression System: HEK293
GAS6 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-04830
Species: Mouse
Expression System: HEK293
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His)
Cat.No: TMPY-03101
Species: Cynomolgus,Rhesus
Expression System: HEK293
BCL2 Protein, Human, Recombinant (His)
Cat.No: TMPY-02700
Species: Human
Expression System: E. coli
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01697
Species: Mouse
Expression System: HEK293
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His)
Cat.No: TMPY-01166
Species: Human
Expression System: HEK293
PD-L1 Protein, Cynomolgus/Rhesus, Recombinant (His)
Cat.No: TMPY-03670
Species: Cynomolgus,Rhesus
Expression System: HEK293
NGFR/p75NTR Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02614
Species: Human
Expression System: HEK293
PD-L1 Protein, Human, Recombinant
Cat.No: TMPY-05208
Species: Human
Expression System: HEK293
PD-L1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01155
Species: Mouse
Expression System: HEK293
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