TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His)

TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.

规格	价格/CNY		数量
10 μg	￥ 380	5日内发货
50 μg	￥ 1,170	5日内发货
500 μg	￥ 5,130	5日内发货
1 mg	￥ 6,720	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 380

5日内发货

50 μg

￥ 1,170

5日内发货

500 μg

￥ 5,130

5日内发货

1 mg

￥ 6,720

5日内发货

产品描述

种属	Human
表达系统	Human Cells
标签	C-Fc-6His
蛋白编号	O14763
别名	DR5, TRAILR2, TRICK2, TNFRSF10B, KILLER, TNF-Related Apoptosis-Inducing Ligand Receptor 2, Tumor Necrosis Factor Receptor Superfamily Member 10B, CD262, TRAIL-R2, Death Receptor 5, ZTNFR9, TRAIL Receptor 2
氨基酸序列	Ile56-Glu182
蛋白构建	Recombinant Human TNF-Related Apoptosis-Inducing Ligand Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ile56-Glu182 is expressed with a human IgG1 Fc, 6His tag at the C-terminus.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	49 KDa, reducing conditions

内毒素	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复溶方法	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
存储	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
研究背景	TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.

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TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His)

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