Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Antitumor agent-53 is a potent compound that effectively inhibits tumor growth. It achieves this by inducing cell cycle arrest at the G2/M phase and promoting apoptosis in HGC-27 cells through the inhibition of the PI3K/AKT pathway. Furthermore, Antitumor agent-53 holds promise for further research in the treatment of gastrointestinal tumors [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 14,900 | 6-8周 | ||
50 mg | ¥ 19,420 | 6-8周 | ||
100 mg | ¥ 24,625 | 6-8周 |
产品描述 | Antitumor agent-53 is a potent compound that effectively inhibits tumor growth. It achieves this by inducing cell cycle arrest at the G2/M phase and promoting apoptosis in HGC-27 cells through the inhibition of the PI3K/AKT pathway. Furthermore, Antitumor agent-53 holds promise for further research in the treatment of gastrointestinal tumors [1]. |
体外活性 | Antitumor agent-53 (compound 6f) (0, 0.22, 0.67, 2, 6, 18 μM; 72 h) shows anti-proliferation activity with IC 50 s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 μM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells [1]. Antitumor agent-53 (0.15, 0.3, 0.6 μM) shows anti-proliferative activity in HGC-27 and HT-29 cells with a dose-dependent manner [1]. Antitumor agent-53 (100, 200 μM) shows a certain inhibitory activity against Topo I at 200 μM [1]. Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) induces cell cycle arrest at the G2/M phase in HGC-27, HT-29 cells [1]. Antitumor agent-53 (0.1, 0.3, 0.9, 2.7 μM; 24 h) induces the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner [1]. Antitumor agent-53 (0.15, 0.3, 0.6 μM; 24 h) inhibits the migration and invasion of HGC-27 cells in a concentration-dependent manner [1]. Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) suppresses the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells [1]. Cell Proliferation Assay [1] Cell Line: HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells Concentration: 0, 0.22, 0.67, 2, 6, 18 μM Incubation Time: 72 h Result: Showed anti-proliferation activity with IC 50 s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 μM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells. Cell Cycle Analysis [1] Cell Line: HGC-27, HT-29 cells Concentration: 0.1, 0.3, 0.9 μM Incubation Time: 24 h Result: Cells were arrest at the G2/M phase. Apoptosis Analysis [1] Cell Line: HGC-27, HT-29 cells Concentration: 0.1, 0.3, 0.9, 2.7 μM Incubation Time: 24 h Result: Induced the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner. Western Blot Analysis [1] Cell Line: HGC-27 cells Concentration: 0.1, 0.3, 0.9 μM Incubation Time: 24 h Result: Suppressed the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells. |
分子量 | 383.42 |
分子式 | C24H18FN3O |
CAS No. | 2757145-67-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Antitumor agent-53 2757145-67-6 Inhibitor inhibitor inhibit