HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.

规格	价格/CNY		货期	数量
100 μg	￥ 4,668	待询
1 mg	￥ 31,175	待询

规格

价格/CNY

货期

数量

100 μg

￥ 4,668

待询

1 mg

￥ 31,175

待询

产品描述

种属	Human
表达系统	HEK293 Cells
标签	C-His-Avi
蛋白编号	A0A140T913(HLA-A*02:01)&P61769(B2M)&HMTEVVRHC
别名	FLJ92943, HLA-A, TP53, Antigen NY-CO-13, TRP53, MHC, BCC7, P53, LFS1
蛋白构建	Gly25-Thr305(HLA-A02:01), Ile21-Met119(B2M) and HMTEVVRHC peptide. PE-labeled Human HLA-A02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin.

内毒素	< 1 EU/μg by the LAL method.
缓冲液	Supplied as 0.22 μm filtered solution in 20 mM PB, 500 mM NaCl, 0.2% BSA (pH 8.0).
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.