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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Minodronic acid

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纯度: 99.39%

货号 T8436Cas号 180064-38-4

别名 米诺磷酸, YM-529, Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-, ONO-5920

Minodronic acid(YM-529) 是一种 P2X2/3 受体拮抗剂， 具有抗癌活性，可直接或间接的抑制癌细胞增殖，诱导细胞凋亡。Minodronic-acid 对各种类型的癌细胞的转移具有抑制作用。Minodronic-acid 可用于研究骨质疏松。

Minodronic acid
其他形式的 “Minodronic acid”:
Minodronic acid-d4
Minodronic acid monohydrate

Minodronic acid

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Rating icon 很棒

纯度: 99.39%

货号 T8436 别名 米诺磷酸, YM-529, Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-, ONO-5920Cas号 180064-38-4

Minodronic acid(YM-529) 是一种 P2X2/3 受体拮抗剂， 具有抗癌活性，可直接或间接的抑制癌细胞增殖，诱导细胞凋亡。Minodronic-acid 对各种类型的癌细胞的转移具有抑制作用。Minodronic-acid 可用于研究骨质疏松。

规格价格库存数量
1 mg
¥ 123
现货
5 mg
¥ 257
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10 mg
¥ 393
现货
25 mg
¥ 659
现货
50 mg
¥ 953
现货
100 mg
¥ 1,320
现货
200 mg
¥ 1,960
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纯度: 99.39%
颜色: 白色
性状: Solid
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产品介绍

Minodronic acid AI Summary
Minodronic acid exhibits a variety of bioactivities across different biological systems. It shows inhibitory activity in the stimulation of TNF-alpha release in gamma-delta T cells with IC50 values ranging from 4100.0 nM to 8000.0 nM. Minodronic acid is also active in inhibiting the growth of Toxoplasma gondii in HFF cells with an IC50 value of 1880.0 nM. It demonstrates antibacterial activity against Escherichia coli W3110, presenting an inhibition zone of 10.0 mm and inhibiting Escherichia coli FPPS with an IC50 value of 1100.0 nM, although it does not affect Escherichia coli pTMV19. In enzyme inhibition assays, Minodronic acid shows potent inhibition of geranylgeranyl diphosphate synthase (GGPPS) in various organisms and binds to yeast and human GGPPS enzymes with low Ki values. It inhibits human FPPS with an IC50 value as low as 1.9 nM and exhibits weaker inhibition against GGPPS (IC50 = 670.0 nM). It also displays cytotoxic effects on mouse J774 cells (IC50 = 3000.0 nM) and inhibits RGGT-mediated prenylation in these cells at 3.0 uM but demonstrates less effect on recombinant RGGT. Moreover, the compound inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with an IC50 of 11885.6 nM. Additionally, Minodronic acid reduces hypercalcemia in subcutaneously dosed rats with an MED of 0.03 mg/kg. In antiviral studies, Minodronic acid inhibits SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells, although with modest inhibition rates. It also inhibits the SARS-CoV-2 3CL-Pro protease by 22.38% at 20 µM. In enzymatic assays, the compound inhibits FDPS with an IC50 value of 3.0 nM and demonstrates HDAC6 inhibition activity, reducing activity by 33.1% using a commercial peptide substrate and by 5.04% with a custom substrate. Overall, Minodronic acid is a multifaceted compound with potential applications in modulating immune responses, antibacterial and antiviral therapies, enzyme inhibition, and potentially as a tool in cancer therapy..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducing apoptosis. Minodronic acid has been shown to inhibit the metastasis of various types of cancer cells.Minodronic-acid has been used in the study of osteoporosis.
别名米诺磷酸, YM-529, Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-, ONO-5920
化学信息
分子量322.15
分子式C9H12N2O7P2
CAS No.180064-38-4
SmilesOC(Cc1cnc2ccccn12)(P(O)(O)=O)P(O)(O)=O
密度1.973 g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: < 1 mg/mL (insoluble or slightly soluble)
H2O: 4 mg/mL (12.42 mM), Sonication is recommended.
溶液配制表
H2O
1mg5mg10mg50mg
1 mM3.1041 mL15.5207 mL31.0414 mL155.2072 mL
5 mM0.6208 mL3.1041 mL6.2083 mL31.0414 mL
10 mM0.3104 mL1.5521 mL3.1041 mL15.5207 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

YM529YM 529P2XReceptorP2X3P2X2P2X ReceptorONO5920ONO 5920Minodronic acidApoptosis
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