购物车
- 全部删除
您的购物车当前为空
CMC2.24
还可以产品编号 T36492Cas号 1255639-43-0
CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-κB/HIF-2α axis[1][2][3].
为众多的药物研发团队赋能，
让新药发现更简单！
CMC2.24
还可以产品编号 T36492Cas号 1255639-43-0
CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-κB/HIF-2α axis[1][2][3].
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 1,470 | 5日内发货 | |
| 5 mg | ¥ 2,490 | 5日内发货 | |
| 25 mg | ¥ 9,930 | 6-8周 | |
| 50 mg | ¥ 12,900 | 6-8周 | |
| 100 mg | ¥ 17,500 | 6-8周 | |
| 1 mL x 10 mM (in DMSO) | ¥ 2,730 | 5日内发货 |
大包装 & 定制
加入购物车
TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
化学信息
| 产品描述 | CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-κB/HIF-2α axis[1][2][3]. |
| 靶点活性 | MMP2:4.8 μM (IC50), MMP7:5 μM (IC50), MMP13:2.7 μM (IC50), MMP9:8 μM (IC50), MMP1:69.8 μM (IC50), MMP12:2 μM (IC50), MMP8:4.5 μM (IC50), MMP3:2.9 μM (IC50), MMP14:15.3 μM (IC50) |
| 体外活性 | CMC2.24 (0-60 μM; 24 hours) inhibits pancreatic cancer growth in vitro[1].CMC2.24 reduces STAT3Ser727 phosphorylation levels, induces mitochondrial reactive oxygen species and mitochondrial cell death in pancreatic cancer cells. CMC2.24 induces mitochondrial reactive oxygen species and intrinsic apoptosis[1]. |
| 体内活性 | CMC2.24 (50 mg/kg; p.o.; five times per week during 17 days) inhibits the growth of pancreatic cancer xenografts[1].CMC2.24 inhibits the growth of human PC through a strong cytokinetic effect. CMC2.24 inhibits ERK signaling pathway in PC cells and xenografts[1]. |
| 分子量 | 427.45 |
| 分子式 | C26H21NO5 |
| CAS No. | 1255639-43-0 |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度信息 | DMSO: < 1 mg/mL (insoluble or slightly soluble) |
SCI 文献
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
评论列表
预览
Related Tags: buy CMC2.24 | purchase CMC2.24 | CMC2.24 cost | order CMC2.24 | CMC2.24 chemical structure | CMC2.24 in vivo | CMC2.24 in vitro | CMC2.24 formula | CMC2.24 molecular weight
嗨！有任何问题？点我咨询
评论内容