Aniline mustard

Name: Aniline mustard
Brand: TargetMol
SKU: T19736
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.54%

货号 T19736Cas号 553-27-5

别名 NSC-18429, N,N-双(2-氯乙基)苯胺, Mesylerythrol, Lymphocin

Aniline mustard (Mesylerythrol) 是具有抗肿瘤活性的烷基化芥末。

Aniline mustard

一键复制产品信息

很棒

纯度: 99.54%

货号 T19736 别名 NSC-18429, N,N-双(2-氯乙基)苯胺, Mesylerythrol, LymphocinCas号 553-27-5

Aniline mustard (Mesylerythrol) 是具有抗肿瘤活性的烷基化芥末。

规格	价格	库存	数量
50 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 149	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.54%

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COA HNMR LCMS 产品操作手册

产品介绍

Aniline mustard AI Summary

Aniline mustard exhibits cytotoxicity against various cells, with a notably lower IC50 value against UV4 cells indicating higher potency compared to AA8 cells. It has a relatively short half-life in culture medium and shows a consistent IC50 of 330.0 nM for UV4 cells after 18 hours of exposure under aerobic conditions, slightly higher under hypoxic conditions. The compound has low level mutagenicity but potential carcinogenicity. Bioactivity includes inhibition of mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) with a potency of 44668.4 nM and human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 1412.5 nM and 1258.9 nM. It also exhibits antitumor activity in various models, showing increased life span in mice and efficacy against various cancer cell lines such as B16, Walker 256, L1210, and P388 cells, with varying doses producing significant T/C ratios. Additionally, Aniline mustard binds to androgen and progesterone receptors with activities of 20.0% and 4.2% respectively, and shows 90.0% tumor growth inhibition in human LNCAP cells xenografted in mice at 30 mg/kg dosage administered intraperitoneally..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Aniline mustard (Mesylerythrol) is alkylating mustard with anti-neoplastic activity.
别名	NSC-18429, N,N-双(2-氯乙基)苯胺, Mesylerythrol, Lymphocin

化学信息

分子量	218.12
分子式	C₁₀H₁₃Cl₂N
CAS No.	553-27-5
Smiles	ClCCN(CCCl)c1ccccc1
密度	1.2431 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (252.15 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.17 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5846 mL	22.9232 mL	45.8463 mL	229.2316 mL
5 mM	0.9169 mL	4.5846 mL	9.1693 mL	45.8463 mL
10 mM	0.4585 mL	2.2923 mL	4.5846 mL	22.9232 mL
20 mM	0.2292 mL	1.1462 mL	2.2923 mL	11.4616 mL
50 mM	0.0917 mL	0.4585 mL	0.9169 mL	4.5846 mL
100 mM	0.0458 mL	0.2292 mL	0.4585 mL	2.2923 mL