(-)-Syringaresinol

Name: (-)-Syringaresinol
Brand: TargetMol
SKU: TJS0487
Price: 687 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.83%

货号 TJS0487Cas号 6216-81-5

别名 Lirioresinol b, DL-Syringaresinol, (-)-丁香脂素

(-)-Syringaresinol (DL-Syringaresinol) 来源于番荔枝 Annona Montana 的茎。 (-)-Syringaresinol 通过 G1 期阻滞和诱导细胞凋亡来抑制人早幼粒细胞 HL-60 细胞的增殖，并具有抗癌活性。

(-)-Syringaresinol

一键复制产品信息

很棒

纯度: 99.83%

货号 TJS0487 别名 Lirioresinol b, DL-Syringaresinol, (-)-丁香脂素Cas号 6216-81-5

规格	价格	库存
1 mg	¥ 288	现货
2 mg	¥ 417	现货
5 mg	¥ 687	现货
10 mg	待询	现货
25 mg	待询	现货
50 mg	待询	现货

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产品介绍

(-)-Syringaresinol AI Summary

(-)-Syringaresinol exhibits a range of bioactivities, including significant antiinflammatory, antiplasmodial, anticancer, and antineuroinflammatory effects. In human neutrophils, it inhibits formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release with an IC50 greater than 50000.0 nM and superoxide anion generation with IC50 values of 39870.0 nM and 40200.0 nM. It demonstrates antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 with an IC50 value greater than 10.0 µg/mL. In terms of antiinflammatory activity, the compound inhibits lipopolysaccharide-induced nitric oxide production in mouse BV2 cells with IC50 values of 13480.0 nM and 27530.0 nM after 24 hours, and interleukin-1beta production in mouse RAW264.7 cells with an IC50 greater than 50000.0 nM. Additionally, it displays anticancer activity against human A549, SK-MEL-2, and XF498 cells with IC50 values exceeding 30000.0 nM, 14470.0 nM, and 8820.0 nM, respectively, while showing less activity against SKOV3 cells with an IC50 value of over 30000.0 nM. (-)-Syringaresinol is also active in inducing supercoiled pSP64 plasmid DNA cleavage, enhancing the nicked form by over 50% at a concentration of 1 µM, as shown by agarose gel electrophoresis. Furthermore, it exhibits cytotoxicity against lipopolysaccharide-stimulated mouse BV2 cells at 20 µM with a relative activity of 110.1% as assessed by MTT assay, and inhibits nitric oxide production in these cells with an IC50 greater than 100000.0 nM after 24 hours..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	(-)-Syringaresinol (DL-Syringaresinol) is derived from the stems of Annona Montana. (-)-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G1 arrest and induction of apoptosis and possesses anti-cancer activity.
别名	Lirioresinol b, DL-Syringaresinol, (-)-丁香脂素

化学信息

分子量	418.44
分子式	C₂₂H₂₆O₈
CAS No.	6216-81-5
Smiles	[H][C@@]12CO[C@@H](c3cc(OC)c(O)c(OC)c3)[C@]1([H])CO[C@H]2c1cc(OC)c(O)c(OC)c1
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 90 mg/mL (215.08 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.89 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3898 mL	11.9491 mL	23.8983 mL	119.4914 mL
5 mM	0.4780 mL	2.3898 mL	4.7797 mL	23.8983 mL
10 mM	0.2390 mL	1.1949 mL	2.3898 mL	11.9491 mL
20 mM	0.1195 mL	0.5975 mL	1.1949 mL	5.9746 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3898 mL
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1949 mL