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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Tetrahydroxyquinone

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纯度: 98.15%

货号 T0223Cas号 319-89-1

别名 四羟基苯醌, Tetroquinone, Tetrahydroxybenzoquinone, Tetrahydroxy-1,4-benzoquinone

Tetrahydroxyquinone (Tetroquinone) 是一种苯醌，是一种抗白内障剂，具有氧化还原活性。它可与半醌自由基一起参与氧化还原循环，导致活性氧形成。

Tetrahydroxyquinone
其他形式的 “Tetrahydroxyquinone”:
Tetrahydroxyquinone disodium
Tetrahydroxyquinone monohydrate

Tetrahydroxyquinone

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Rating icon 很棒

纯度: 98.15%

货号 T0223 别名 四羟基苯醌, Tetroquinone, Tetrahydroxybenzoquinone, Tetrahydroxy-1,4-benzoquinoneCas号 319-89-1

Tetrahydroxyquinone (Tetroquinone) 是一种苯醌，是一种抗白内障剂，具有氧化还原活性。它可与半醌自由基一起参与氧化还原循环，导致活性氧形成。

规格价格库存数量
25 mg
¥ 132
现货
50 mg
¥ 178
现货
100 mg
¥ 247
现货
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纯度: 98.15%
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产品介绍

Tetrahydroxyquinone AI Summary
Tetrahydroxyquinone exhibits a broad spectrum of bioactivities, targeting various enzymes, receptors, and pathogens. It shows inhibitory activity against human Jumonji Domain Containing 2E (JMJD2E) with a potency of 12589.3 nM and Tyrosyl-DNA Phosphodiesterase (TDP1) with a potency of 2818.4 nM. Additionally, it inhibits Tau Fibril Formation, Aldehyde Dehydrogenase 1 (ALDH1A1), Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase), 15-hLO, 12-hLO, Bloom's syndrome helicase (BLM), menin-MLL interaction, Fructose-1,6-bisphosphate Aldolase, glutaminase (GLS), the vitamin D receptor (VDR), Polymerase Kappa, USP1/UAF1, and human Apurinic/apyrimidinic Endonuclease 1 (APE1) at various potency levels. For pathogen inhibition, Tetrahydroxyquinone exhibits activity against the malarial parasite plastid and blocks Ebola virus entry. It also demonstrates antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells. The compound inhibits SARS-CoV-2 3CL-Pro protease by -5.192% at 20 µM. In terms of other biological functions, Tetrahydroxyquinone acts as an antioxidant with an IC50 value of 9370.0 nM for DPPH radical scavenging. It effectively blocks sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells, indicating its potential as a transporter inhibitor. Furthermore, it inhibits wild-type His-tagged translin/trax E126A mutant in E. coli with 66.0% inhibition and reduces ATP-dependent [3H]-taurocholate transport into vesicles with an IC50 value greater than 1000000.0 nM for human BSEP inhibition. Overall, Tetrahydroxyquinone is a multi-targeting agent that could be valuable in diverse therapeutic applications due to its varied bioactivities..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Tetrahydroxyquinone (Tetroquinone) is a molecule best known as a primitive anticataract drug, is also a highly redox active molecule that can take part in a redox cycle with semiquinone radicals, leading to the formation of reactive oxygen species (ROS).
别名四羟基苯醌, Tetroquinone, Tetrahydroxybenzoquinone, Tetrahydroxy-1,4-benzoquinone
化学信息
分子量172.09
分子式C6H4O6
CAS No.319-89-1
SmilesOC1=C(O)C(=O)C(O)=C(O)C1=O
密度2.609 g/cm3
储存&溶解度
存储keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 1.6 mg/mL (9.3 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.81 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM5.8109 mL29.0546 mL58.1091 mL290.5456 mL
5 mM1.1622 mL5.8109 mL11.6218 mL58.1091 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

TetrahydroxyquinoneredoxReactiveOxygenSpeciesReactive Oxygen SpeciesmitochondrialCytotoxicbenzoquinoneApoptosisAntioxidantanticataract
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