Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LDCA 是一种双hit 代谢调节剂,展现出强大的抗增殖活性。LDCA 能竞争性地抑制LDH-A 酶的活性,改变线粒体的超极化并同时颠覆细胞凋亡。LDCA 在癌细胞中作用明显且不显示出毒性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 281 | 现货 | ||
5 mg | ¥ 663 | 现货 | ||
10 mg | ¥ 1,080 | 现货 | ||
25 mg | ¥ 1,980 | 现货 | ||
50 mg | ¥ 3,320 | 现货 | ||
100 mg | ¥ 4,880 | 现货 | ||
500 mg | ¥ 9,870 | 现货 |
产品描述 | LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. lDCA has a pronounced effect in cancer cells and does not show toxicity. |
体外活性 | LDCA (2-100 μM ; 16-72 h) and Doxorubicin combination synergistically inhibit tumor progression. 15% death when cells were exposed to LDCA individually and caused 40% melanoma cell death combination synergistically with doxorubicin.[1] |
体内活性 | LDA (2 mg/kg, iv., 6 days ; once) combination with doxorubicin effectively alleviated tumor necrosis in mice and significantly improved their survival ability, leading to sustained limitations in tumor growth kinetics.[1] |
分子量 | 256.49 |
分子式 | C8H5Cl3FNO |
CAS No. | 349106-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (350.9 mM ), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.8988 mL | 19.4939 mL | 38.9879 mL | 97.4697 mL |
5 mM | 0.7798 mL | 3.8988 mL | 7.7976 mL | 19.4939 mL | |
10 mM | 0.3899 mL | 1.9494 mL | 3.8988 mL | 9.747 mL | |
20 mM | 0.1949 mL | 0.9747 mL | 1.9494 mL | 4.8735 mL | |
50 mM | 0.078 mL | 0.3899 mL | 0.7798 mL | 1.9494 mL | |
100 mM | 0.039 mL | 0.1949 mL | 0.3899 mL | 0.9747 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LDCA 349106-80-5 Apoptosis Metabolism Dehydrogenase Inhibitor inhibitor inhibit