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4,7-DIHYDROXYCOUMARIN

Name: 4,7-DIHYDROXYCOUMARIN
Brand: TargetMol
SKU: T4137
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.2%

货号 T4137Cas号 1983-81-9

别名 4,7-二羟基香豆素

4,7-DIHYDROXYCOUMARIN 是一种天然存在的香豆素衍生物，存在于多种植物中，包括欧芹和洋甘菊。已经发现它可以抑制几种酶的活性，包括细胞色素P450、环氧合酶和脂氧合酶；也可以与DNA 结合，调节基因表达，并抑制细胞周期进展；还可以诱导肿瘤细胞凋亡并减轻炎症。

4,7-DIHYDROXYCOUMARIN

一键复制产品信息

很棒

纯度: 99.2%

货号 T4137 别名 4,7-二羟基香豆素Cas号 1983-81-9

规格	价格	库存	数量
100 mg	¥ 138	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.2%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

4,7-DIHYDROXYCOUMARIN AI Summary

4,7-DIHYDROXYCOUMARIN exhibits multifunctional bioactivities, notably including inhibition of HIV-1 integrase with IC50 values of 300,000 nM and 325,000 nM for 3'-processing and DNA integration, respectively. It also inhibits Human Jumonji Domain Containing 2E (JMJD2E) with an IC50 of 28,183.8 nM, MLL CXXC domain - DNA interaction with 89,125.1 nM, Aldehyde Dehydrogenase 1 (ALDH1A1) with 25,118.9 nM, and RanGTP-induced Rango - Importin beta complex dissociation with 4,109.5 nM. Its potency extends to delayed death inhibitors of the malarial parasite plastid (928.5 nM) and as a substrate for Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) at 39,810.7 nM. Additionally, it acts as an agonist for gsp with a potency of 891.3 nM and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells in the absence and presence of CPT with potencies of 23,109.3 nM and 16,360.1 nM, respectively. 4,7-DIHYDROXYCOUMARIN also inhibits TDP-43 (14,125.4 nM) and Alpha-syn (22,387.2 nM) and has inhibitory effects on alpha-glucosidase (IC50 of 38,850.0 nM) and beta-glucosidase (36.7% reduction at 400 μM), although it does not inhibit Aspergillus oryzae Beta-galactosidase at the same concentration. Furthermore, it significantly alters the secondary structure of alpha-glucosidase, impacting the alpha-helix, beta-sheet, beta-turn, and random content..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

4,7-DIHYDROXYCOUMARIN is a naturally occurring coumarin derivative found in a variety of plants, including parsley and chamomile. It has been found to inhibit the activity of several enzymes, including cytochrome P450, cyclooxygenase and lipoxygenase. It can also bind to DNA, regulate gene expression, and inhibit cell cycle progression. It can also induce apoptosis in tumor cells and reduce inflammation.

别名

4,7-二羟基香豆素

化学信息

分子量	178.14
分子式	C₉H₆O₄
CAS No.	1983-81-9
Smiles	Oc1ccc2c(O)cc(=O)oc2c1
密度	1.612g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (336.81 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6136 mL	28.0678 mL	56.1356 mL	280.6781 mL
5 mM	1.1227 mL	5.6136 mL	11.2271 mL	56.1356 mL
10 mM	0.5614 mL	2.8068 mL	5.6136 mL	28.0678 mL
20 mM	0.2807 mL	1.4034 mL	2.8068 mL	14.0339 mL
50 mM	0.1123 mL	0.5614 mL	1.1227 mL	5.6136 mL
100 mM	0.0561 mL	0.2807 mL	0.5614 mL	2.8068 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

4,7-DIHYDROXYCOUMARIN 4,7DIHYDROXYCOUMARIN 4,7 DIHYDROXYCOUMARIN

4,7-DIHYDROXYCOUMARIN

4,7-DIHYDROXYCOUMARIN