6-Azuridine

Name: 6-Azuridine
Brand: TargetMol
SKU: TNU0022
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.02%

货号 TNU0022Cas号 54-25-1

别名 氮杂尿苷, 6-Azuridine

6-Azauridine (6-Azuridine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.6-Azuridine's anticancer mechanism is dependent on the inhibition of DNA synthesis.

6-Azuridine

一键复制产品信息

很棒

纯度: 99.02%

货号 TNU0022 别名 氮杂尿苷, 6-AzuridineCas号 54-25-1

规格	价格	库存	数量
200 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 108	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.02%

联系我们获取更多批次信息

资源下载:

COA HPLC HNMR 产品操作手册

产品介绍

6-Azuridine AI Summary

6-Azuridine exhibits a broad range of antiviral activities against various viruses including West Nile Virus, Dengue virus, Respiratory syncytial virus (RSV), Yellow fever virus (YFV), Chikungunya virus, and others, with effective concentration (EC50) values ranging from 468.0 nM to over 25000.0 nM. It also shows moderate antifungal and antibacterial activities against specific pathogens. The compound has demonstrated significant in vivo efficacy, notably increasing the lifespan of mice with L1210 leukemia by over 25% at a dose of 400 mg/kg. In terms of cytotoxicity, 6-Azuridine exhibits varying levels of toxicity against different cell lines such as Vero cells, MT4 cells, and murine leukemia L1210 cells, with cytotoxic concentration (CC50) values ranging from 200.0 nM to greater than 100000.0 nM, indicating a generally lower cytotoxicity at higher concentrations. The selectivity indices calculated suggest a favorable therapeutic window for treatments against specific viruses such as RSV and YFV. 6-Azuridine also demonstrates inhibitory activities against Plasmodium species and yeast, and is capable of targeting various biological processes including cancer cell targeting with p53 mutations and modulating miRNA expression. Although it exhibits no significant inhibition against SARS-CoV-2, the compound's broad spectrum of activity against other viral and microbial pathogens indicates its potential as a valuable antiviral and antimicrobial agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	6-Azauridine (6-Azuridine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.6-Azuridine's anticancer mechanism is dependent on the inhibition of DNA synthesis.
别名	氮杂尿苷, 6-Azuridine

化学信息

分子量	245.19
分子式	C₈H₁₁N₃O₆
CAS No.	54-25-1
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc(=O)[nH]c1=O
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (224.32 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.16 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0785 mL	20.3923 mL	40.7847 mL	203.9235 mL
5 mM	0.8157 mL	4.0785 mL	8.1569 mL	40.7847 mL
10 mM	0.4078 mL	2.0392 mL	4.0785 mL	20.3923 mL
20 mM	0.2039 mL	1.0196 mL	2.0392 mL	10.1962 mL
50 mM	0.0816 mL	0.4078 mL	0.8157 mL	4.0785 mL
100 mM	0.0408 mL	0.2039 mL	0.4078 mL	2.0392 mL