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TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated

产品编号 TMPJ-00275
别名: DR5, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRAIL Receptor 2, CD262, Death Receptor 5, ZTNFR9, TRICK2, TNF-Related Apoptosis-Inducing Ligand Receptor 2, TRAIL-R2, TRAILR2, TNFRSF10B, KILLER

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 18-25 KDa and the accession number is O14763.

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TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated
规格 价格/CNY 货期 数量
20 μg ¥ 2,260 5日内发货
100 μg ¥ 6,130 5日内发货
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产品目录号及名称: TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated (TMPJ-00275)
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产品描述 TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 18-25 KDa and the accession number is O14763.
种属 Human
表达系统 HEK293 Cells
标签 C-Avi-6xHis
蛋白编号 O14763
别名 DR5, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRAIL Receptor 2, CD262, Death Receptor 5, ZTNFR9, TRICK2, TNF-Related Apoptosis-Inducing Ligand Receptor 2, TRAIL-R2, TRAILR2, TNFRSF10B, KILLER
氨基酸序列 Ile56-Glu182
蛋白构建 Ile56-Glu182
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 18-25 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.

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Keywords

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated DR5 Tumor Necrosis Factor Receptor Superfamily Member 10B ZTNFR-9 TRAIL Receptor 2 CD262 TRAILR-2 Death Receptor 5 ZTNFR9 DR 5 TRICK2 TNF-Related Apoptosis-Inducing Ligand Receptor 2 TRICK-2 CD 262 TRAIL-R2 TRAILR 2 TRAILR2 CD-262 DR-5 TNFRSF10B TRICK 2 KILLER ZTNFR 9 recombinant recombinant-proteins proteins protein

 

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