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TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)
Synonyms: ZTNFR9, TRICKB, TRICK2A, TRICK2, TRAILR2, TRAIL receptor 2, TRAIL R2, TNFRSF10B, KILLER/DR5, KILLER, Fas-like protein, DR5TRICK2B, DR5, CD262货号 TMPK-00277 一键复制产品信息
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还可以DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)
一键复制产品信息 还可以货号 TMPK-00277
别名 ZTNFR9, TRICKB, TRICK2A, TRICK2, TRAILR2, TRAIL receptor 2, TRAIL R2, TNFRSF10B, KILLER/DR5, KILLER, Fas-like protein, DR5TRICK2B, DR5, CD262
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
其他形式的 “TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)”:
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 268 | 6-8日内发货 | |
| 10 μg | ¥ 419 | 6-8日内发货 | |
| 20 μg | ¥ 678 | 5日内发货 | |
| 50 μg | ¥ 1,320 | 5日内发货 | |
| 100 μg | ¥ 2,210 | 5日内发货 | |
| 200 μg | ¥ 3,930 | 5日内发货 | |
| 500 μg | ¥ 8,900 | 5日内发货 |
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| 产品描述 | DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
| 生物活性 | Immobilized Human Trail, No Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human TRAIL R2, hFc Tag with the EC50 of 4.8ng/ml determined by ELISA. |
| 研究背景 | DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
| 种属 | Human |
| 表达系统 | HEK293 Cells |
| 标签 | C-hFc |
| 蛋白编号 | O14763-1 |
| 蛋白构建 | Ile56-Glu182 |
| 蛋白纯度 | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| 蛋白性状 | Lyophilized powder |
| 缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 100 mM NaCl (pH 7.5). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| 复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| 别名 | ZTNFR9, TRICKB, TRICK2A, TRICK2, TRAILR2, TRAIL receptor 2, TRAIL R2, TNFRSF10B, KILLER/DR5, KILLER, Fas-like protein, DR5TRICK2B, DR5, CD262 |
| 内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
| 分子量 | 41.1 kDa (predicted). Due to glycosylation, the protein migrates to 50-55 kDa based on Tris-Bis PAGE result. |
| 运输方式 | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| 存储 |
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