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2,4,6-Triiodophenol

Name: 2,4,6-Triiodophenol
Brand: TargetMol
SKU: T8628
Price: 183 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 2,4,6-三碘苯酚

货号 T8628Cas号 609-23-4 一键复制产品信息纯度: 98.11%

很棒

2,4,6-Triiodophenol 用作废水氯化过程中形成的碘化消毒副产物。它也被用作一种有效的甲状腺干扰化学物质和研究脱碘酶。

2,4,6-Triiodophenol

一键复制产品信息

很棒

纯度: 98.11%

货号 T8628Cas号 609-23-4

别名 2,4,6-三碘苯酚

2,4,6-Triiodophenol 用作废水氯化过程中形成的碘化消毒副产物。它也被用作一种有效的甲状腺干扰化学物质和研究脱碘酶。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
2 mg	¥ 183	现货
5 mg	¥ 283	现货
10 mg	¥ 342	现货
25 mg	¥ 413	现货
50 mg	¥ 517	现货
100 mg	¥ 629	现货
500 mg	¥ 1,550	现货
1 mL x 10 mM (in DMSO)	¥ 293	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 98.11%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

2,4,6-Triiodophenol AI Summary

2,4,6-Triiodophenol exhibits a range of bioactivities, primarily related to thyroxine binding and inhibition of TTR-mediated fibrillogenesis. It shows a binding affinity of 384.0 in a competition binding assay against prealbumin, relative to L-T4 (100), and a thyroxine binding constant on human plasma prealbumin of KT4 = 7.39E-7 M-1, with a KPCB value of 0.0000075 M-1. Its KPCB/K352 ratio of 33.8 highlights its competitive effectiveness. In rat liver assays, it has a relative binding affinity for thyroxin binding prealbumin (TBPA) that is 10.15 times that of T4, and for nuclear receptors, it is 0.27 times that of T4. In terms of inhibiting TTR-mediated fibrillogenesis, 2,4,6-Triiodophenol has an IC50 of 3200.0 nM and achieves 80.0% inhibition relative to the control. Additionally, 2,4,6-Triiodophenol displays significant antimicrobial and antiparasitic activities against Cryptosporidium parvum, achieving between 36.0% to 99.6% growth inhibition in infected HCT8 cells depending on concentration and timing. It also has antiviral properties, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 uM, albeit with variable inhibition rates of -2.63% and 0.15%, respectively. It shows 7.667% inhibition of SARS-CoV-2 3CL-Pro protease at 20µM, suggesting potential efficacy in disrupting viral replication. Lastly, 2,4,6-Triiodophenol displays a moderate inhibitory effect on human HDAC6 enzyme activity, with differing inhibition levels of 29.72% using a commercial peptide substrate and -19.41% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2,4,6-Triiodophenol is used as an iodinated disinfection by product formed during chlorination of sewage effluents. It is also used as a potent thyroid disrupting chemical and to investigate deiodinase
别名	2,4,6-三碘苯酚

化学信息

分子量	471.8
分子式	C₆H₃I₃O
CAS No.	609-23-4
Smiles	Oc1c(I)cc(I)cc1I
密度	2.8493 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 250 mg/mL (529.89 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Saline: 10 mg/mL (21.2 mM), Suspension.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1195 mL	10.5977 mL	21.1954 mL	105.9771 mL
5 mM	0.4239 mL	2.1195 mL	4.2391 mL	21.1954 mL
10 mM	0.2120 mL	1.0598 mL	2.1195 mL	10.5977 mL
20 mM	0.1060 mL	0.5299 mL	1.0598 mL	5.2989 mL
50 mM	0.0424 mL	0.2120 mL	0.4239 mL	2.1195 mL
100 mM	0.0212 mL	0.1060 mL	0.2120 mL	1.0598 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。