Fludioxonil exhibits a broad spectrum of bioactivities. It demonstrates significant antifungal activity against various plant pathogens, including Saccharomyces cerevisiae, Botryotinia fuckeliana, Monilinia laxa, Rhizoctonia solani, and Ceratobasidium cereale, with varying degrees of effectiveness. Specifically, it shows strong efficacy in controlling Botryotinia fuckeliana in tomato seedlings and cucumber cotyledon, with activities up to 100% at certain concentrations. It also inhibits mycelial growth of Monilinia laxa and Rhizoctonia solani with low EC50 values, indicating potent antifungal properties.
Additionally, Fludioxonil affects multiple signaling pathways; it acts as an agonist for retinoid X receptor alpha, peroxisome proliferator-activated receptor gamma, the antioxidant response element signaling pathway, and rat pregnane X receptor signaling. Conversely, it serves as an antagonist for farnesoid X receptor, androgen receptor, peroxisome proliferator-activated receptor delta, vitamin D receptor, glucocorticoid receptor, aryl hydrocarbon receptor, and human pregnane X receptor signaling pathways.
In terms of photosynthesis inhibition, Fludioxonil reduces several photosynthetic metrics in Vitis vinifera cv. Pinot noir, including the Hill reaction activity, relative quantum yield of photosystem 2, and net photosynthetic rate, while increasing mitochondrial respiration in the light.
The compound also exhibits antiviral activity against SARS-CoV-2 in vitro, with an IC50 value greater than 20000 nM, suggesting moderate potency.
Collectively, these findings highlight the multifaceted bioactivity of Fludioxonil, making it a promising candidate for further investigation in agricultural and medical biotechnology applications..
Note: Summary generated by AI. Data source: ChEMBL 