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顶部相关产品产品介绍化学信息储存和溶解信息计算器

1-(1-Naphthyl) piperazine hydrochloride

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纯度: 98.27%

货号 T21569Cas号 104113-71-5

别名 1-naphthalen-1-ylpiperazine hydrochloride, 1-(Naphthalen-1-yl)piperazine hydrochloride

1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) 是一种 5-羟色胺能配体，可与多种 5-羟色胺 (5-HT) 受体非选择性结合。

1-(1-Naphthyl) piperazine hydrochloride
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1-(1-Naphthyl) piperazine hydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 98.27%

货号 T21569 别名 1-naphthalen-1-ylpiperazine hydrochloride, 1-(Naphthalen-1-yl)piperazine hydrochlorideCas号 104113-71-5

1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) 是一种 5-羟色胺能配体，可与多种 5-羟色胺 (5-HT) 受体非选择性结合。

规格价格库存数量
5 mg
¥ 120
现货
10 mg
¥ 179
现货
25 mg
¥ 309
现货
50 mg
¥ 457
现货
100 mg
¥ 693
现货
1 mL x 10 mM (in DMSO)
¥ 99
现货
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选择批次:
纯度: 98.27%
颜色: 黄色
性状: Solid
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资源下载:
COA LCMS HNMR产品操作手册

产品介绍

1-(1-Naphthyl) piperazine hydrochloride AI Summary
1-(1-Naphthyl) piperazine hydrochloride exhibits a diverse range of bioactivities. It shows antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 7943.28 nM to 15848.93 nM after 72 hours. It also inhibits the proliferation of Plasmodium falciparum lines Dd2, 3D7, W2, 7G8, and D10, with potencies ranging from 7943.3 nM to 17782.8 nM. Additionally, 1-(1-Naphthyl) piperazine hydrochloride acts as a modulator of Lamin A splicing (5.6 nM), inhibitor of Jumonji Domain Containing 2E (25118.9 nM), and inducer of genomic imprint erasure (12589.3 nM). It also inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) (35481.3 nM), Human Peripheral Myelin Protein 22 (PMP22) expression/activity (42561.5 nM), Influenza NS1 protein function (35481.3 nM), HPGD activity (28183.8 nM to 3768.6 nM), MPP8 chromodomain interactions (79432.8 nM), Histone Lysine Methyltransferase G9a (10000.0 nM), HP1-beta chromodomain interactions (100000.0 nM), and Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) with potencies of 28183.8 nM and 3768.6 nM. Moreover, 1-(1-Naphthyl) piperazine hydrochloride inhibits Polymerase Iota (25118.9 nM), the Human hERG channel (35481.3 nM), Marburg Virus binding/entry (11220.2 nM to 29081.0 nM), mitochondrial permeability transition pore (IC50 of 80000.0 nM), and Hepatitis C Virus (HCV) (10000.0 nM). In addition, it induces DNA re-replication in MCF 10a normal breast cells (231.1 nM) and SW480 colon adenocarcinoma cells (5.8 nM). It also functions as an inhibitor of GLP-1 receptor inverse agonists (7079.5 nM) and human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells, both with and without CPT, displaying potencies of 9200.0 nM and 29092.9 nM, respectively..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) is a serotonergic ligand which could bind nonselectively with multiple serotonin (5-HT) receptors.
别名1-naphthalen-1-ylpiperazine hydrochloride, 1-(Naphthalen-1-yl)piperazine hydrochloride
化学信息
分子量248.75
分子式C14H17ClN2
CAS No.104113-71-5
SmilesCl.C1CN(CCN1)C1=CC=CC2=CC=CC=C12
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 30 mg/mL (120.6 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM4.0201 mL20.1005 mL40.2010 mL201.0050 mL
5 mM0.8040 mL4.0201 mL8.0402 mL40.2010 mL
10 mM0.4020 mL2.0101 mL4.0201 mL20.1005 mL
20 mM0.2010 mL1.0050 mL2.0101 mL10.0503 mL
50 mM0.0804 mL0.4020 mL0.8040 mL4.0201 mL
100 mM0.0402 mL0.2010 mL0.4020 mL2.0101 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

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