DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 2,140 | 5日内发货 | ||
500 μg | ¥ 8,600 | 5日内发货 | ||
1 mg | ¥ 14,300 | 5日内发货 |
生物活性 | Immobilized Human TRAIL R2, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 8.5ng/ml determined by ELISA. |
产品描述 | DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | C-His-Avi |
蛋白编号 | O14763-1 |
别名 | ZTNFR9, DR5TRICK2B, DR5, TRAIL receptor 2, TRICKB, TNFRSF10B, TRICK2, Fas-like protein, TRAILR2, CD262, TRAIL R2, KILLER/DR5, KILLER, TRICK2A |
蛋白构建 | Ile56-Glu182 |
蛋白纯度 | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
分子量 | 17.2 kDa (predicted). Due to glycosylation, the protein migrates to 20-25 kDa based on Tris-Bis PAGE result. |
内毒素 | < 1 EU/μg by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
bottom
您可能有的问题的答案可以在重组蛋白操作手册中找到
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi) DR-5 ZTNFR 9 ZTNFR9 DR5TRICK2B DR5 CD-262 TRAIL receptor 2 ZTNFR-9 TRICKB TNFRSF10B TRICK2 TRICK-2 Fas-like protein CD 262 TRAILR2 TRAILR-2 DR 5 TRAILR 2 CD262 TRAIL R2 KILLER/DR5 KILLER TRICK 2 TRICK2A recombinant recombinant-proteins proteins protein