Avenanthramide A-d4 is the deuterium-labeled form of Avenanthramide A. This compound is a plant defensin found in oats (Avena sativa L.). It targets the RNA helicase DDX3, leading to mitochondrial swelling, increased ROS production, and induction of apoptosis in CRC cells. In mouse models, Avenanthramide A has demonstrated antitumor activity and exhibits oral bioavailability.