SJY26 is a dual-target inhibitor of PI3K/HDAC, exhibiting IC50 values of 0.59 nM for PI3Kα and PI3Kδ, 2.02 nM for PI3Kγ, 12.69 nM for PI3Kβ, and 114 nM for HDAC1. It has potent antiproliferative activity across a broad spectrum, particularly affecting Jurkat and PC9R cells. SJY26 inhibits the migration of PC9R cells, induces cell cycle arrest, and triggers apoptosis. It also reduces AKT phosphorylation and decreases acetylation of histone H3 (Ac-H3). SJY26 is applicable for research in non-small cell lung cancer and leukemia.

PI3Kα:0.59 nM