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Dantrolene sodium
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很棒纯度: 99.87%
货号 T0077Cas号 14663-23-1
别名 丹曲林钠, Dantrolene sodium salt
Dantrolene sodium (Dantrolene sodium salt) 是一种骨骼肌松弛药，是一种钙通道蛋白抑制剂，可抑制钙离子从肌浆释放。
Dantrolene sodium
一键复制产品信息 很棒纯度: 99.87%
货号 T0077 别名 丹曲林钠, Dantrolene sodium saltCas号 14663-23-1
Dantrolene sodium (Dantrolene sodium salt) 是一种骨骼肌松弛药，是一种钙通道蛋白抑制剂，可抑制钙离子从肌浆释放。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 mg | ¥ 343 | 现货 | |
| 100 mg | ¥ 497 | 现货 | |
| 200 mg | ¥ 685 | 现货 | |
| 500 mg | ¥ 1,170 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 159 | 现货 |
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产品介绍
Dantrolene sodium AI Summary
Dantrolene sodium exhibits a diverse range of bioactivities across various assay types. It shows potent antiplasmodial activity against Plasmodium falciparum strains with IC50 values between 5011.9 nM to 11220.2 nM and significant inhibition of gastrocnemius twitch tension in rats following a cumulative dose of 36.6 mg/kg intravenously. Additionally, it demonstrates antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and Vero-6 cells, albeit with variable inhibition rates.
Furthermore, Dantrolene sodium has a binding affinity with a Kd value of 300.0 nM against porcine sarcoplasmic reticulum and displays varying levels of activity in inhibiting APE1, Tau fibril formation, Bloom's syndrome helicase, and Human Peripheral Myelin Protein 22. It also inhibits OATP1B1 and OATP1B3-mediated sodium fluorescein uptake in CHO cells at 10 µM concentration, indicating potential interference with these transporters.
In addition, Dantrolene sodium inhibits the Ca2+-induced mitochondrial permeability transition in human HL60 cells and shows minimal bioactivity against Candida albicans, Cryptococcus neoformans, Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus MRSA, with varying inhibition percentages. However, its antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and its antifungal activity against some pathogens appears to be low. Overall, Dantrolene sodium holds potential for multiple therapeutic applications due to its broad-spectrum activity..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Dantrolene sodium (Dantrolene sodium salt) is a skeletal muscle relaxant and can interfere with excitation-contraction coupling in the muscle fiber. It is used for the treatment of spasticity and other neuromuscular abnormalities. Its mechanism of action is may not central, but dantrolene is usually grouped with the central muscle relaxants. |
| 别名 | 丹曲林钠, Dantrolene sodium salt |
| 分子量 | 336.23 |
| 分子式 | C14H9N4NaO5 |
| CAS No. | 14663-23-1 |
| Smiles | O.[Na+].[O-]C1=NC(=O)CN1\N=C\c1ccc(o1)-c1ccc(cc1)[N+]([O-])=O |
| 密度 | no data available |
| 颜色 | orange |
| 物理性状 | Solid |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | DMSO: 3.4 mg/mL (10.11 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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