购物车

您的购物车当前为空

Dantrolene sodium

Name: Dantrolene sodium
Brand: TargetMol
SKU: T0077
Price: 159 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 丹曲林钠, Dantrolene sodium salt

货号 T0077Cas号 14663-23-1 一键复制产品信息纯度: 99.87%

很棒

Dantrolene sodium (Dantrolene sodium salt) 是一种骨骼肌松弛药，是一种钙通道蛋白抑制剂，可抑制钙离子从肌浆释放。

Dantrolene sodium

一键复制产品信息

很棒

纯度: 99.87%

货号 T0077Cas号 14663-23-1

别名 丹曲林钠, Dantrolene sodium salt

Dantrolene sodium (Dantrolene sodium salt) 是一种骨骼肌松弛药，是一种钙通道蛋白抑制剂，可抑制钙离子从肌浆释放。

规格	价格	库存
50 mg	¥ 343	现货
100 mg	¥ 497	现货
200 mg	¥ 685	现货
500 mg	¥ 1,170	现货
1 mL x 10 mM (in DMSO)	¥ 159	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.87%

资源下载: COA LCMS HPLC HNMR产品操作手册

产品介绍

Dantrolene sodium AI Summary

Dantrolene sodium exhibits a diverse range of bioactivities across various assay types. It shows potent antiplasmodial activity against Plasmodium falciparum strains with IC50 values between 5011.9 nM to 11220.2 nM and significant inhibition of gastrocnemius twitch tension in rats following a cumulative dose of 36.6 mg/kg intravenously. Additionally, it demonstrates antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and Vero-6 cells, albeit with variable inhibition rates. Furthermore, Dantrolene sodium has a binding affinity with a Kd value of 300.0 nM against porcine sarcoplasmic reticulum and displays varying levels of activity in inhibiting APE1, Tau fibril formation, Bloom's syndrome helicase, and Human Peripheral Myelin Protein 22. It also inhibits OATP1B1 and OATP1B3-mediated sodium fluorescein uptake in CHO cells at 10 µM concentration, indicating potential interference with these transporters. In addition, Dantrolene sodium inhibits the Ca2+-induced mitochondrial permeability transition in human HL60 cells and shows minimal bioactivity against Candida albicans, Cryptococcus neoformans, Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus MRSA, with varying inhibition percentages. However, its antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and its antifungal activity against some pathogens appears to be low. Overall, Dantrolene sodium holds potential for multiple therapeutic applications due to its broad-spectrum activity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dantrolene sodium (Dantrolene sodium salt) is a skeletal muscle relaxant and can interfere with excitation-contraction coupling in the muscle fiber. It is used for the treatment of spasticity and other neuromuscular abnormalities. Its mechanism of action is may not central, but dantrolene is usually grouped with the central muscle relaxants.
别名	丹曲林钠, Dantrolene sodium salt

化学信息

分子量	336.23
分子式	C₁₄H₉N₄NaO₅
CAS No.	14663-23-1
Smiles	O.[Na+].[O-]C1=NC(=O)CN1\N=C\c1ccc(o1)-c1ccc(cc1)[N+]([O-])=O
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 3.4 mg/mL (10.11 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9742 mL	14.8708 mL	29.7415 mL	148.7077 mL
5 mM	0.5948 mL	2.9742 mL	5.9483 mL	29.7415 mL
10 mM	0.2974 mL	1.4871 mL	2.9742 mL	14.8708 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Ryanodine receptor 1 F-440 F440 F 440 Dantrolene sodium Dantrolene CalciumChannel Calcium Channel

Dantrolene sodium

Dantrolene sodium