Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DJ4 在微摩尔范围内以剂量依赖性诱导促凋亡作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 496 | 现货 | ||
5 mg | ¥ 1,210 | 现货 | ||
10 mg | ¥ 1,890 | 现货 | ||
25 mg | ¥ 3,660 | 现货 | ||
50 mg | ¥ 5,270 | 现货 | ||
100 mg | ¥ 7,430 | 现货 | ||
500 mg | ¥ 14,800 | 现货 |
产品描述 | DJ4 induces a dose-dependent pro-apoptotic effect in the micromolar range. |
体外活性 | In cellular functional assays, DJ4 inhibited migration of humanmelanoma, lung, pancreatic and breast cancer cells in a concentration-dependent manner. In live cellimaging over 20h by time-lapse microscopy, DJ4 (2.5 pM ) reduced the migration rate of lung-andbreast-cancer cells by 2.7 and 5.5 times compared to control cells respectively, DJ4 (5 pM) alsoinhibited invasion of MDA-MB-231 breast cancer cells by ~70%. Fluorescent microscopicobservation also revealed that inhibition of activity of these kinases, by DJ4, causes reduction instress fibers which leads to inhibition of cell contractility and migration.[1] |
分子量 | 350.44 |
分子式 | C19H18N4OS |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.63 mg/mL (16.05 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8536 mL | 14.2678 mL | 28.5356 mL | 71.3389 mL |
5 mM | 0.5707 mL | 2.8536 mL | 5.7071 mL | 14.2678 mL | |
10 mM | 0.2854 mL | 1.4268 mL | 2.8536 mL | 7.1339 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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