规格

价格

库存

数量

50 mg

¥ 139

现货

100 mg

¥ 187

现货

500 mg

¥ 400

现货

1 g

¥ 575

现货

5 g

¥ 1,390

现货

生物活性

产品描述	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, anticancer and tumour growth inhibiting properties. Cholesteryl Hemisuccinate inhibits the hepatotoxicity of acetaminophen and prevents AAP-induced apoptosis and necrosis in hepatocytes. Cholesteryl Hemisuccinate inhibits DNA polymerase and DNA topoisomerase, thereby inhibiting DNA replication and repair as well as cell division.
体外活性	Cholesteryl Hemisuccinate (0-1000 μM) 抑制了MCF-7和MCF-10A细胞的生长。[3]
体内活性	Cholesteryl Hemisuccinate（100 mg/kg；ip；AAP前单次给药）在ICR小鼠（CD-1）中消除了AAP引起的凋亡和坏死，用于组织学和生化诊断。[1]
别名	胆甾醇半琥珀酸酯, Cholesterol hydrogen succinate

化学信息

分子量	486.73
分子式	C₃₁H₅₀O₄
CAS No.	1510-21-0
Smiles	[H][C@@]12CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OC(=O)CCC(O)=O
密度	1.06 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10 mg/mL (20.55 mM), Sonication is recommended.

Ethanol: 22.5 mg/mL (46.23 mM), Sonication is recommended.

体内实验配方

10% EtOH+90% Corn Oil: 2 mg/mL (4.11 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/Ethanol