3-hydroxy-3-phenylpentanamide

Name: 3-hydroxy-3-phenylpentanamide
Brand: TargetMol
SKU: T50100
Price: 833 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.42%

货号 T50100Cas号 131802-69-2

3-hydroxy-3-phenylpentanamide 是一种手性化合物，属于β-羟基酰胺类。在神经病学中，它已被证明对缺血性脑损伤和脑出血具有神经保护作用。在精神病学中，它被研究为焦虑、抑郁和成瘾的潜在治疗方法。在肿瘤学中，它已被证明通过诱导细胞凋亡和抑制肿瘤生长而具有抗肿瘤活性。

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3-hydroxy-3-phenylpentanamide

一键复制产品信息

很棒

纯度: 98.42%

货号 T50100Cas号 131802-69-2

规格	价格	库存
1 mg	¥ 833	现货
5 mg	¥ 1,930	现货
10 mg	¥ 2,830	现货
25 mg	¥ 4,480	现货
50 mg	¥ 5,920	现货
100 mg	¥ 8,100	现货
200 mg	¥ 10,900	现货
1 mL x 10 mM (in DMSO)	¥ 1,470	现货

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纯度: 98.42%

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COA HNMR LCMS 产品操作手册

产品介绍

3-hydroxy-3-phenylpentanamide AI Summary

3-hydroxy-3-phenylpentanamide exhibits diverse bioactivities, with notable antiviral properties demonstrated by its ability to inhibit SARS-CoV-2 induced cytotoxicity in Caco-2 cells (inhibitory effect of 29.94% at 10 µM after 48 hours) and VERO-6 cells (inhibition of -0.1% at 10 µM after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus). Furthermore, the compound inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 15.81% at 20 µM, suggesting potential as a protease inhibitor. In antibacterial assays, 3-hydroxy-3-phenylpentanamide shows inhibition rates against Pseudomonas aeruginosa ATCC 27853 (1.83%) and Acinetobacter baumannii ATCC 19606 (11.78%), but has a negative inhibition rate against Pseudomonas aeruginosa PAO397 (-9.36%). Additionally, the compound exhibits bioactivity against Mycobacterium tuberculosis and minor inhibition of an enzyme related to Toxoplasma. It also shows varying inhibition on the human HDAC6 enzyme with 21.65% inhibition on a commercial peptide substrate and -6.56% on a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

3-hydroxy-3-phenylpentanamide is a chiral compound belonging to the class of beta-hydroxyamides. In neurology, it has been shown to have neuroprotective effects against ischemic brain injury and cerebral hemorrhage. In psychiatry, it has been studied as a potential treatment for anxiety, depression and addiction. In oncology, it has been shown to have antitumor activity by inducing apoptosis and inhibiting tumor growth.

化学信息

分子量	193.24
分子式	C₁₁H₁₅NO₂
CAS No.	131802-69-2
Smiles	C(CC(N)=O)(CC)(O)C1=CC=CC=C1
密度	1.13g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (258.75 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1749 mL	25.8746 mL	51.7491 mL	258.7456 mL
5 mM	1.0350 mL	5.1749 mL	10.3498 mL	51.7491 mL
10 mM	0.5175 mL	2.5875 mL	5.1749 mL	25.8746 mL
20 mM	0.2587 mL	1.2937 mL	2.5875 mL	12.9373 mL
50 mM	0.1035 mL	0.5175 mL	1.0350 mL	5.1749 mL
100 mM	0.0517 mL	0.2587 mL	0.5175 mL	2.5875 mL