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顶部产品介绍化学信息储存和溶解信息计算器技术支持

pro-BDNF Protein, Human, Recombinant

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纯度: 99%

货号 TMPJ-00134

别名 Brain-Derived Neurotrophic Factor, BDNF, Abrineurin

The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

pro-BDNF Protein, Human, Recombinant
其他形式的 “pro-BDNF Protein, Human, Recombinant”:
BDNF Protein, Human/Murine/Rat, Recombinant
BDNF (human)
BDNF Protein, Mouse, Recombinant (His)

pro-BDNF Protein, Human, Recombinant

一键复制产品信息
Rating icon 还可以
SPR兼容缓冲液

纯度: 99%

货号 TMPJ-00134 别名 Brain-Derived Neurotrophic Factor, BDNF, Abrineurin

The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

规格价格库存数量
5 μg
¥ 492
6-8日内发货
10 μg
¥ 820
6-8日内发货
20 μg
¥ 1,290
5日内发货
50 μg
¥ 2,480
5日内发货
100 μg
¥ 3,980
5日内发货
200 μg
¥ 6,420
5日内发货
500 μg
¥ 12,100
5日内发货
1 mg
¥ 17,300
5日内发货
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纯度: 99%
颜色: 无色透明
性状: Solution
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资源下载:
COA重组蛋白用户指南

产品介绍

生物活性
产品描述
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
生物活性
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
种属
Human
表达系统
E. coli
标签Tag Free
蛋白编号P23560
氨基酸序列Ala19-Arg247(R125A,R127A,R128A)
蛋白构建Ala19-Arg247(R125A,R127A,R128A)
蛋白纯度
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液Supplied as a 0.2 μm filtered solution of 20 mM PB, 10% Trehalose, 100 mM NaCl, 0.02% Tween 80, pH 6.0.
别名Brain-Derived Neurotrophic Factor, BDNF, Abrineurin
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量28 KDa (reducing condition)
储存&溶解度
运输方式In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
存储

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剂量转换

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技术支持

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