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pro-BDNF Protein, Human, Recombinant

pro-BDNF Protein, Human, Recombinant

产品编号 TMPJ-00134
别名: Brain-Derived Neurotrophic Factor, Abrineurin, BDNF

The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

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pro-BDNF Protein, Human, Recombinant
规格 价格/CNY 货期 数量
10 μg ¥ 820 5日内发货
50 μg ¥ 2,480 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: pro-BDNF Protein, Human, Recombinant (TMPJ-00134)
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产品描述 The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
种属 Human
表达系统 E. coli
标签 Tag Free
蛋白编号 P23560
别名 Brain-Derived Neurotrophic Factor, Abrineurin, BDNF
氨基酸序列 Ala19-Arg247(R125A,R127A,R128A)
蛋白构建 Ala19-Arg247(R125A,R127A,R128A)
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 28 KDa (reducing condition)
内毒素 < 1 EU/μg by the LAL method.
缓冲液 Supplied as a 0.2 μm filtered solution of 20 mM PB, 10% Trehalose, 100 mM NaCl, 0.02% Tween 80, pH 6.0.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

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Keywords

pro-BDNF Protein, Human, Recombinant Brain-Derived Neurotrophic Factor Abrineurin BDNF recombinant recombinant-proteins proteins protein

 

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