Name: pro-BDNF Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPJ-00134
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 492

6-8日内发货

10 μg

¥ 820

6-8日内发货

20 μg

¥ 1,290

5日内发货

50 μg

¥ 2,480

5日内发货

100 μg

¥ 3,980

5日内发货

200 μg

¥ 6,420

5日内发货

500 μg

¥ 12,100

5日内发货

1 mg

¥ 17,300

5日内发货

生物活性

产品描述	The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景	The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	P23560
氨基酸序列	Ala19-Arg247(R125A,R127A,R128A)
蛋白构建	Ala19-Arg247(R125A,R127A,R128A)
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液	Supplied as a 0.2 μm filtered solution of 20 mM PB, 10% Trehalose, 100 mM NaCl, 0.02% Tween 80, pH 6.0.
别名	Brain-Derived Neurotrophic Factor, BDNF, Abrineurin
内毒素	< 1 EU/μg by the LAL method.

化学信息

分子量	28 KDa (reducing condition)
颜色	Transparent
物理性状	Solution

储存&溶解度

运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

pro-BDNF Protein, Human, Recombinant

pro-BDNF Protein, Human, Recombinant

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