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顶部生物活性储存和溶解信息计算器

Anti-PRPF8 Antibody (4V102)

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产品编号 TMAC-03447

别名 U5 snRNP specific protein (220 kD), ortholog of S. cerevisiae Prp8p, U5 snRNP specific protein, Splicing factor Prp8, SNRNP220, RP13, Retinitis pigmentosa 13 (autosomal dominant), Prpf 8, PRPC8, PRP8_HUMAN, PRP8 pre mRNA processing factor 8 homolog, PRP8 homolog, PRP8, Pre-mRNA-processing-splicing factor 8, Precursor mRNA processing protein, Pre mRNA-processing factor 8, S. cerevisiae, homolog of, Pre mRNA processing factor 8, p220, HPRP8, Apoptosis regulated protein 2, Apoptosis regulated protein 1, 220 kDa U5 snRNP-specific protein, 220 kDa U5 snRNP specific protein

Anti-PRPF8 Antibody (4V102) 是一种 Rabbit 抗体，靶向 PRPF8。Anti-PRPF8 Antibody (4V102) 可用于 FCM,ICC,IHC,WB。

Anti-PRPF8 Antibody (4V102)

Anti-PRPF8 Antibody (4V102)

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产品编号 TMAC-03447 别名 U5 snRNP specific protein (220 kD), ortholog of S. cerevisiae Prp8p, U5 snRNP specific protein, Splicing factor Prp8, SNRNP220, RP13, Retinitis pigmentosa 13 (autosomal dominant), Prpf 8, PRPC8, PRP8_HUMAN, PRP8 pre mRNA processing factor 8 homolog, PRP8 homolog, PRP8, Pre-mRNA-processing-splicing factor 8, Precursor mRNA processing protein, Pre mRNA-processing factor 8, S. cerevisiae, homolog of, Pre mRNA processing factor 8, p220, HPRP8, Apoptosis regulated protein 2, Apoptosis regulated protein 1, 220 kDa U5 snRNP-specific protein, 220 kDa U5 snRNP specific protein

Anti-PRPF8 Antibody (4V102) 是一种 Rabbit 抗体，靶向 PRPF8。Anti-PRPF8 Antibody (4V102) 可用于 FCM,ICC,IHC,WB。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,490
5日内发货
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生物活性
产品描述
Anti-PRPF8 Antibody (4V102) is a Rabbit antibody targeting PRPF8. Anti-PRPF8 Antibody (4V102) can be used in FCM,ICC,IHC,WB.
别名U5 snRNP specific protein (220 kD), ortholog of S. cerevisiae Prp8p, U5 snRNP specific protein, Splicing factor Prp8, SNRNP220, RP13, Retinitis pigmentosa 13 (autosomal dominant), Prpf 8, PRPC8, PRP8_HUMAN, PRP8 pre mRNA processing factor 8 homolog, PRP8 homolog, PRP8, Pre-mRNA-processing-splicing factor 8, Precursor mRNA processing protein, Pre mRNA-processing factor 8, S. cerevisiae, homolog of, Pre mRNA processing factor 8, p220, HPRP8, Apoptosis regulated protein 2, Apoptosis regulated protein 1, 220 kDa U5 snRNP-specific protein, 220 kDa U5 snRNP specific protein
Ig Type
IgG
克隆号
4V102
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of PRPF8 on SiHa (1) and A549 (2) cell lysate using anti-PRPF8 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-PRPF8 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-PRPF8 antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue using anti-PRPF8 antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-PRPF8 antibody. Counter stained with hematoxylin.
6. ICC staining PRPF8 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
7. ICC staining PRPF8 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
8. ICC staining PRPF8 in SiHa cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
9. Flow cytometric analysis of A549 cells with PRPF8 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
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应用FCMICCIHCWB
推荐剂量
WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景PRP8, also designated pre-mRNA-processing-splicing factor 8, is a highly conserved nuclear protein and a central component of the catalytic core of the spliceosome, where it may be involved in various molecular rearrangements. PRP8, which is widely expressed, plays a role in transesterification reactions that regulate splicesome-induced pre-mRNA splicing. Specifically, PRP8 interacts with the GU dinucleotide at the 5' splice site (5'SS) and forms a specific UV-inducible cross-link. It also interacts functionally with the 3'SS, affecting the efficiency of the second catalytic step. PRP8 may play a role in the first transesterification step, as PRP8 mutations that prohibit negative regulation of PRP28 or PRP44/Brr2 subsequently block U4 activation. In addition, PRP8 interacts with a conserved region of U6 that is instrumental in the formation of the catalytic core of the spliceosome.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: 1C200 of human PRPF8
抗原种属
human
Uniprot ID
Q6P2Q9
化学信息
分子量Theoretical: 274 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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