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顶部生物活性储存和溶解信息计算器

Anti-ASPP2 Antibody (2W253)

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Anti-ASPP2 Antibody (2W253)
产品编号 TMAC-00289
别名 Tumor suppressor p53-binding protein 2, Tumor suppressor p53 binding protein 2, Tumor protein p53 binding protein 2, Tp53bp2, Renal carcinoma antigen NY-REN-51, PPP1R13A, p53BP2, p53-binding protein 2, p53 binding protein 2, NY REN 51 antigen, Bcl2-binding protein, Bcl2 binding protein, BBP, ASPP2_HUMAN, ASPP 2, Apoptosis-stimulating of p53 protein 2, Apoptosis stimulating protein of p53 2, Apoptosis stimulating of p53 protein 2, 53BP2

Anti-ASPP2 Antibody (2W253) 是一种 Rabbit 抗体，靶向 ASPP2。Anti-ASPP2 Antibody (2W253) 可用于 WB,ICC/IF,IHC。

Anti-ASPP2 Antibody (2W253)

Anti-ASPP2 Antibody (2W253)

Rating icon 还可以
Anti-ASPP2 Antibody (2W253)
产品编号 TMAC-00289 别名 Tumor suppressor p53-binding protein 2, Tumor suppressor p53 binding protein 2, Tumor protein p53 binding protein 2, Tp53bp2, Renal carcinoma antigen NY-REN-51, PPP1R13A, p53BP2, p53-binding protein 2, p53 binding protein 2, NY REN 51 antigen, Bcl2-binding protein, Bcl2 binding protein, BBP, ASPP2_HUMAN, ASPP 2, Apoptosis-stimulating of p53 protein 2, Apoptosis stimulating protein of p53 2, Apoptosis stimulating of p53 protein 2, 53BP2

Anti-ASPP2 Antibody (2W253) 是一种 Rabbit 抗体，靶向 ASPP2。Anti-ASPP2 Antibody (2W253) 可用于 WB,ICC/IF,IHC。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-ASPP2 Antibody (2W253) is a Rabbit antibody targeting ASPP2. Anti-ASPP2 Antibody (2W253) can be used in WB,ICC/IF,IHC.
别名Tumor suppressor p53-binding protein 2, Tumor suppressor p53 binding protein 2, Tumor protein p53 binding protein 2, Tp53bp2, Renal carcinoma antigen NY-REN-51, PPP1R13A, p53BP2, p53-binding protein 2, p53 binding protein 2, NY REN 51 antigen, Bcl2-binding protein, Bcl2 binding protein, BBP, ASPP2_HUMAN, ASPP 2, Apoptosis-stimulating of p53 protein 2, Apoptosis stimulating protein of p53 2, Apoptosis stimulating of p53 protein 2, 53BP2
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of ASPP2 on different lysates using anti-ASPP2 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: MCF-7.
2. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ASPP2 antibody. Counter stained with hematoxylin.
3. ICC staining ASPP2 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining ASPP2 in 293T cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC/IF
IHC
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The p53 binding proteins 53BP1 and 53BP2 (Bbp) bind to the central DNA-binding domain of wild type p53, but do not bind mutant p53. The central DNA-binding domain of p53 is required for site-specific DNA binding and is frequently mutated in malignant tumors. Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation. Site-specific binding also suggests that 53BP1 and 53BP2 are involved in p53-mediated tumor suppression. 53BP1 was isolated from H258 cells and is expressed in Jurkat cells in both the cytoplasm and the nucleus. The N-terminus of 53BP2 is localized to the cytoplasm, while the C-terminus might be localized in the nucleus. 53BP1 promotes cell proliferation by binding to p202, whereas 53BP2 induces cell death by binding to Bcl2 and NFkB p65.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q13625
化学信息
分子量Theoretical: 150 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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