Aurora kinase inhibitor-14 (Compound 79) is an orally active and highly selective inhibitor of Aurora kinases, effectively inhibiting both Aurora A and Aurora B with IC50 values of 0.5 nM and 1.2 nM, respectively. It binds to the ATP binding site of Aurora kinases, blocking chromosome separation during mitosis and inducing apoptosis in tumor cells. Aurora kinase inhibitor-14 shows potential for research in various solid tumors and hematologic malignancies, such as non-small cell lung cancer, breast cancer, and acute myeloid leukemia.

Aurora A:0.5 nM