Name: 1D09C3
Brand: TargetMol
SKU: T9901A-1797
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 12,000

待询

5 mg

待询

生物活性

产品描述	1D09C3 is a fully humanized anti-HLA-DR monoclonal antibody. It induces cell apoptosis (apoptosis) and death through a cascade of reactions, including reactive oxygen species (ROS) production, JNK activation, mitochondrial membrane depolarization, and the release of AIF from mitochondria. In xenograft models with JVM-2 cells and GRANTA-519 cells in mice, 1D09C3 demonstrated significant antitumor activity, improving overall survival and median survival time. This compound is applicable in cancer research, including studies on chronic lymphocytic leukemia (CLL).
体外活性	1D09C3 (2.5 µg/mL, 24 h) 能显著降低 HLA-DR 阳性细胞系的细胞数量和存活率，而对 HLA-DR 阴性细胞系无影响。1D09C3 (0.1-10 µg/mL, 4-24 h) 可以在 JVM-2 和 GRANTA-519 细胞中引发强烈的时间和剂量依赖性死亡。使用 1D09C3 (10 µg/mL, 4-24 h) 会通过非 caspase 依赖的途径诱发 JVM-2 和 GRANTA-519 细胞的凋亡。1D09C3 (10 µg/mL, 5-240 min) 能在 JVM-2 和 GRANTA-519 细胞中引起线粒体去极化和活性氧（ROS）的产生。1D09C3 (10 µg/mL, 0.5-4 h) 通过激活 JNK 诱导细胞死亡。1D09C3 (2.5 µg/mL, 4 h) 能够诱导 B-CLL 细胞死亡。此外，1D09C3 (10 µg/mL, 48 h) 使活化的 T 细胞减少 20%，静止和活化的 B 细胞减少 50%。
体内活性	1D09C3 (0.01-6 mg/mouse, 静脉注射) 在 JVM-2 细胞和 GRANTA-519 细胞异种移植瘤的小鼠模型中明显延长了总生存期和中位生存期。

化学信息

CAS No.

791073-97-7

储存&溶解度

存储	store at low temperature \| store at -20°C \| Shipping with blue ice/Shipping at ambient temperature.

1D09C3