Name: Picolinafen
Brand: TargetMol
SKU: T211625
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

10-14周

50 mg

待询

10-14周

产品介绍

生物活性

产品描述	Picolinafen is a pyridine herbicide that functions as an inhibitor of phytoene desaturase (PDS) and is utilized for its ability to manage the growth of broadleaf weeds by disrupting carotenoid biosynthesis. It exhibits cytotoxicity towards porcine trophoblast cells (pTr) and porcine luminal epithelial cells (pLE). By inducing the accumulation of reactive oxygen species (ROS), depleting calcium, and activating MAPK and PI3K signaling pathways, Picolinafen leads to reduced cell viability, increased apoptosis, impaired migration abilities, and altered expression of implantation-related genes, ultimately affecting the implantation capability of pTr cells. The LD50 value of Picolinafen for mammals is 2.7 mg/kg, and it is 7 μg/L for fish. Additionally, Picolinafen shows toxic effects during zebrafish embryonic development.
体外活性	Picolinafen (0.2-6 μM, 48 h) 降低猪胚胎滋养外胚层细胞 (pTr) 和子宫腔上皮细胞 (pLE) 的活力，并改变细胞周期进程。Picolinafen (1-4 μM, 48 h) 诱导 pTr 和 pLE 细胞凋亡，干扰细胞球的自组装能力，影响线粒体完整性和钙稳态。Picolinafen (1-4 μM, 2-48 h) 在 pTr 和 pLE 细胞中引起 ROS 积累并破坏钙调控。Picolinafen (4 μM, 15-24 h) 抑制 pTr 细胞迁移，影响与凋亡和着床相关的基因转录。Picolinafen (1-4 μM, 3 h) 激活在 pTr 和 pLE 细胞中的 MAPK 和 PI3K/AKT 信号通路。
体内活性	在斑马鱼胚胎中，Picolinafen (0.1-100 μM，孵育，0-5 天) 的 3 天 LC 50 为 10 μM，5 天 LC 50 为 5 μM。Picolinafen (1-10 μM，孵育，24-72 h) 会在斑马鱼胚胎发育期间产生毒性效应。
别名	氟吡酰草胺, AC 900001