Name: XmAb5485
Brand: TargetMol
SKU: T9901A-1755
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 12,000

待询

5 mg

待询

生物活性

产品描述	XmAb5485 is a humanized anti-CD40 monoclonal antibody engineered with an Fc domain modification, exhibiting high affinity for Fc-γ receptors. It effectively induces antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) against tumor cells. Additionally, XmAb5485 suppresses tumor cell proliferation and triggers apoptosis. This compound demonstrates pronounced cytotoxicity against lymphoma, leukemia, multiple myeloma cell lines, and primary cancer cells.
体外活性	XmAb5485 在 Ramos 细胞中表现出强效的抗体依赖性细胞吞噬作用 (ADCP)。通过抗体依赖性细胞介导的细胞毒性 (ADCC)，XmAb5485 抑制多种来自原发性患者的 CLL、MCL 细胞和浆细胞白血病细胞的增殖，并诱导其发生凋亡。
体内活性	XmAb5485 (6 mg/kg) 在体积为 210-350 mm³ 的皮下 Ramos 异种移植瘤小鼠模型中展现了显著的抗肿瘤活性，治愈了 80% 的可检测到肿瘤的小鼠。

储存&溶解度

存储	store at low temperature \| store at -20°C \| Shipping with blue ice/Shipping at ambient temperature.

XmAb5485