还可以
Thalidomide-O-amide-C5-NH2 is a chemically synthesized conjugate, serving as an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide with a linker that is commonly employed in PROTAC technology.
还可以Thalidomide-O-amide-C5-NH2 is a chemically synthesized conjugate, serving as an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide with a linker that is commonly employed in PROTAC technology.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 10,600 | 期货 |
| 产品描述 | Thalidomide-O-amide-C5-NH2 is a chemically synthesized conjugate, serving as an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide with a linker that is commonly employed in PROTAC technology. |
| 体外活性 | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| 别名 | Thalidomide-O-amide-C5-NH2 |
| 分子量 | 416.43 |
| 分子式 | C20H24N4O6 |
| CAS No. | 2360527-40-6 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 一共给药动物 10 只 ，您使用的配方为 5% 
DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为 2 mg/mL 。 母液，添加 300 μLPEG300 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2O 混匀澄清 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
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