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Harmalol
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很棒纯度: 98.94%
货号 T8770Cas号 525-57-5
别名 骆驼蓬酚, Harmidol
Harmalol (Harmidol) 是一种具有生物活性的 β-咔啉，是 harmalal 生物碱的成员
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Harmalol
一键复制产品信息 很棒纯度: 98.94%
货号 T8770 别名 骆驼蓬酚, HarmidolCas号 525-57-5
Harmalol (Harmidol) 是一种具有生物活性的 β-咔啉，是 harmalal 生物碱的成员
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 737 | 现货 | |
| 5 mg | ¥ 1,570 | 现货 | |
| 10 mg | ¥ 2,150 | 现货 | |
| 25 mg | ¥ 3,870 | 现货 | |
| 50 mg | ¥ 5,550 | 现货 | |
| 100 mg | ¥ 7,770 | 现货 | |
| 500 mg | ¥ 15,500 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 1,170 | 现货 |
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产品介绍
生物活性
化学信息
储存&溶解度
| 产品描述 | Harmalol (Harmidol) is a bioactive beta-carboline and a member of the harmala alkaloids |
| 别名 | 骆驼蓬酚, Harmidol |
| 分子量 | 200.24 |
| 分子式 | C12H12N2O |
| CAS No. | 525-57-5 |
| Smiles | CC=1C2=C(C=3C(N2)=CC(O)=CC3)CCN1 |
| 密度 | 1.28g/cm3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 79.17 mg/mL (395.38 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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TCMIP相关数据
中药材来源及性味归经
| 中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
|---|---|---|---|---|
| 鸡蛋果 | Passiflora edulis Sims | 平 | 甘, 酸 | 心, 大肠 |
| 骆驼蓬 | Peganum harmala L. | 平 | 辛, 苦 |
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
TargetMol AI Summary
Harmalol exhibits a range of bioactivities across different biological targets. Despite showing a low binding affinity towards the 5-hydroxytryptamine 5A receptor (Ki > 10000.0 nM), it acts as an inhibitor for cyclin-dependent kinase 5 (CDK 5) with a 15.0% inhibition rate and cyclin-dependent kinase 2 (CDK 2) with a 13.0% inhibition rate at 50 µM. It significantly inhibits the SRC2-3 interaction at the androgen receptor ligand binding domain with an inhibition percentage of 162.0% at 50 µM over 2 hours.
In antiplatelet activity assays, it inhibits collagen-induced platelet aggregation in rabbit platelets with an IC50 value greater than 130,000.0 nM. It also demonstrates notable acetylcholinesterase (AChE) inhibition, showing an IC50 of 11280.0 nM and inhibiting electric eel AChE activity by 88.61% at 10^-4 M, and human AChE by 49.66% at the same concentration.
Harmalol inhibits various enzyme activities, including native rhodanese, soluble pig heart MDH, Escherichia coli GroEL/GroES-mediated refolding activities, and ATPase activity of Escherichia coli GroEL, with IC50 values ranging from 9700.0 nM to >250000.0 nM and inhibition percentages from 82.0% to 87.0%. Additionally, it shows antifungal activity against Candida albicans with a MIC value of 750.0 µg/mL (72 hours incubation).
Overall, Harmalol has a complex bioactivity profile, influencing multiple signaling pathways and enzyme activities, suggesting considerable potential for therapeutic applications in various disease contexts..
Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl 
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