Name: YZ-35
Brand: TargetMol
SKU: T211347
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

产品介绍

生物活性

产品描述	YZ-35 is a STAT3 inhibitor with a Ki value of 0.38 μM. It binds directly to STAT3 with high affinity, having a dissociation constant (Kd) of 190 nM. YZ-35 effectively inhibits the dual phosphorylation of STAT3 at Tyr705 and Ser727 sites. It also suppresses colony formation, cell migration, and induces apoptosis in breast cancer cell lines. Additionally, YZ-35 selectively inhibits the self-renewal capability of breast cancer stem cells (BCSC) and reduces tumor growth in breast cancer stem cell xenograft models. YZ-35 is applicable for breast cancer research.
体外活性	在浓度为0.1-100 μM的条件下，YZ-35在48小时内对MDA-MB-231细胞 (IC 50 = 0.63 μM)、MCF-7细胞 (IC 50 = 0.32 μM) 和 MCF-10A细胞 (IC 50 = 34.34 μM)展现出抑制作用。 YZ-35 (0-4 μM, 0-48 h) 能有效削弱MDA-MB-231和MCF-7细胞中STAT3的双重磷酸化 (Tyr705 和 Ser727)，展现出显著的抗乳腺癌效果。 YZ-35 (0-6 μM, 24-48 h) 抑制MDA-MB-231和MCF-7细胞的集落形成和迁移，同时诱导细胞凋亡。 YZ-35 (2.5-10 μM, 48 h) 还可以降低MDA-MB-231和MCF-7细胞的肿瘤干性。
体内活性	YZ-35 (5-10 mg/kg，静脉给药，每日一次，持续 21 天) 显著抑制 BCSC 异种移植模型中的肿瘤生长。