Name: Anti-IGF1R/CD221 Antibody
Brand: TargetMol
SKU: T9901A-1374
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-IGF1R/CD221 Antibody is a highly specific monoclonal antibody targeting the Type I Insulin-like Growth Factor Receptor (IGF-1R/CD221). By binding to the extracellular domain of IGF-1R, this antibody effectively blocks the interaction with its ligands IGF-1 and IGF-2, thereby inhibiting the activation of downstream PI3K/Akt and MAPK signaling pathways. It is a vital tool for researching tumor cell growth inhibition, apoptosis induction, and transmembrane signaling mechanisms.
体外活性	在细胞实验中，Anti-IGF1R/CD221 Antibody显著抑制了 IGF-1 诱导的受体自身磷酸化，并抑制了包括乳腺癌和肺癌在内的多种人癌细胞系的增殖 [1]。
体内活性	在肿瘤异种移植模型中，系统给予 Anti-IGF1R 抗体可导致肿瘤体积明显缩小，并诱导癌细胞凋亡显著增加 [1]。
别名	抗IGF1R/CD221抗体
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P08069
靶点	IGF-1R/CD221

储存&溶解度

存储

Anti-IGF1R/CD221 Antibody