Name: BIM-46174
Brand: TargetMol
SKU: T70039
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

2-4周

50 mg

¥ 13,800

2-4周

100 mg

¥ 17,500

2-4周

生物活性

产品描述	BIM-46174 is a 5,6,7,8-tetrahydroimidazole [1,2-a] pyrazine derivative that inhibits the heterotrimeric Galpha/Gbetagamma protein complex and has anticancer activity, inhibiting the growth of a large number of human cancer cell lines, inducing caspase-3-dependent cancer cell apoptosis, and inducing poly (ADP-ribose) polymerase cleavage.
体外活性	方法：BIM-46174 (20 μM, 30min )预处理 RAW-blue 巨噬细胞 ,然后用 10 μg/mL 咪喹莫特处理。通过 SDS-PAGE 分离 WT 和 KD 细胞的细胞裂解物，并用抗 NF-κBp65-Ser （P）的磷酸化特异性多克隆兔抗体探测印迹。结果：BIM-46174显着阻断核酸诱导的 TLR-7 和 -9 MyD88 募集、NF-κB 激活和促炎性 TNFα 和 MCP-1 细胞因子反应。[3]
别名	BIM46174, BIM 46174

化学信息

分子量	398.57
分子式	C₂₂H₃₀N₄OS
CAS No.	195450-11-4
Smiles	C([C@H]1C=2N(C=C(N2)C3=CC=CC=C3)CCN1C([C@H](CS)N)=O)C4CCCCC4

储存&溶解度

存储	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

BIM-46174