Cystamine dihydrochloride

Name: Cystamine dihydrochloride
Brand: TargetMol
SKU: T20109
Price: 195 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.81%

货号 T20109Cas号 56-17-7

别名 胱胺二盐酸盐

Cystamine dihydrochloride 是一种辐射防护剂。它还可以防止四氯化碳肝损伤。

Cystamine dihydrochloride

一键复制产品信息

很棒

纯度: 99.81%

货号 T20109 别名 胱胺二盐酸盐Cas号 56-17-7

Cystamine dihydrochloride 是一种辐射防护剂。它还可以防止四氯化碳肝损伤。

规格	价格	库存	数量
10 g	¥ 278	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

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COA LCMS HNMR 产品操作手册

产品介绍

Cystamine dihydrochloride AI Summary

Cystamine dihydrochloride exhibits a range of bioactivities, including potent inhibition of the proliferation of Plasmodium falciparum line 3D7 with an IC50 of 8912.5 nM. It serves as an inhibitor of Tyrosyl-DNA Phosphodiesterase (TDP1) with IC50 values of 28183.8 nM and 1778.3 nM. Additionally, Cystamine dihydrochloride inhibits Tau Fibril Formation, with potencies between 12589.3 nM and 14125.4 nM. It is also effective as a cell-membrane permeable IMPase inhibitor, showing potency at 5623.4 nM. Furthermore, the compound displays inhibitory activities on Fructose-1,6-bisphosphate Aldolase, MPP8 Chromodomain Interactions, Histone Lysine Methyltransferase G9a, vitamin D receptor (VDR), Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), and Marburg Virus entry, with potencies spanning from 44.7 nM to 79432.8 nM. In terms of transporter interactions, Cystamine dihydrochloride strongly inhibits sodium fluorescein uptake, demonstrating an 89.2% inhibition in OATP1B3-transfected CHO cells and 111.28% in OATP1B1-transfected CHO cells at a 10 µM concentration, indicating its capacity to interfere with the transport mechanisms mediated by these transporters. Additionally, Cystamine dihydrochloride acts as an inhibitor of histone lysine methyltransferases G9a with an IC50 of 15000.0 nM, albeit showing weaker inhibition of GLP, with an IC50 greater than 100000.0 nM. It also has a weak to negligible inhibitory effect on ALDH1A1, as evidenced by an IC50 value exceeding 100000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.
靶点活性	Caspase-3:23.6 μM
别名	胱胺二盐酸盐

化学信息

分子量	225.19
分子式	C₄H₁₄Cl₂N₂S₂
CAS No.	56-17-7
Smiles	C(CSSCCN)N.Cl.Cl
密度	1.172g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (222.03 mM), Sonication is recommended.

H2O: 50 mg/mL (222.03 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.88 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.4407 mL	22.2035 mL	44.4069 mL	222.0347 mL
5 mM	0.8881 mL	4.4407 mL	8.8814 mL	44.4069 mL
10 mM	0.4441 mL	2.2203 mL	4.4407 mL	22.2035 mL
20 mM	0.2220 mL	1.1102 mL	2.2203 mL	11.1017 mL
50 mM	0.0888 mL	0.4441 mL	0.8881 mL	4.4407 mL
100 mM	0.0444 mL	0.2220 mL	0.4441 mL	2.2203 mL