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Chloranil

Name: Chloranil
Brand: TargetMol
SKU: T80673
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 四氯苯醌, p-Chloranil

货号 T80673Cas号 118-75-2 一键复制产品信息纯度: 98.03%

很棒

Chloranil (tetrachloro-p-benzoquinone)通过 Toll 样受体 4 信号传导引发炎症和神经功能障碍，可用于小鼠炎症造模。

Chloranil

一键复制产品信息

很棒

纯度: 98.03%

货号 T80673Cas号 118-75-2

别名 四氯苯醌, p-Chloranil

Chloranil (tetrachloro-p-benzoquinone)通过 Toll 样受体 4 信号传导引发炎症和神经功能障碍，可用于小鼠炎症造模。

规格	价格	库存	数量
10 g	¥ 99	现货
25 g	¥ 136	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 98.03%

颜色: 黄色

性状: Solid

资源下载: COA CNMR LCMS 产品操作手册

产品介绍

Chloranil AI Summary

Chloranil exhibits notable bioactivity across a variety of biological targets and pathogens. It functions as an inhibitor of several esterases and cholinesterases, with inhibition constants (Ki) of 57.4 nM, 83.9 nM, and 54.8 nM against human intestinal carboxylesterase 2, human liver carboxylesterase 1, and rabbit liver carboxylesterase, respectively. It also inhibits human Acetylcholinesterase and Butyrylcholinesterase with Ki values of 163.0 nM and 268.0 nM. Additionally, Chloranil shows antiparasitic activity against Trichomonas vaginalis strains T1 and G3 with 12.0% and 40.0% inhibition at 100 µM, respectively. The compound demonstrates cytotoxicity against cancer cells and inhibition of cellular functions such as DNA helicase, hormone receptors, and kinase signaling pathways. It exhibits toxicity against Trichoplusia ni larvae with a 10.0% mortality rate at 10 µg/ml and a feeding deterrence effect of 35.8% at 50 µg/cm². In cellular transport assays, Chloranil inhibits the uptake of sodium fluorescein in OATP1B3- and OATP1B1-transfected CHO cells by 74.83% and 80.53%, respectively. Remarkably, Chloranil has antimalarial activity against chloroquine-sensitive Plasmodium falciparum with an IC50 of 22400.0 nM and a selectivity index greater than 4.4 against human MRC5 cells. It strongly inhibits the refolding activity of GroEL/GroES proteins in Escherichia coli, resulting in a 92.0% reduction in enzyme activity in both rhodanese and soluble pig heart MDH assays. In addition to its enzymatic inhibition properties, Chloranil exhibits significant antiviral activity against SARS-CoV-2. It inhibits the SARS-CoV-2 3CL-Pro protease with an IC50 of less than 20.0 nM, achieving 102.77% inhibition at 20 µM. Moreover, it reduces SARS-CoV-2 induced cytotoxicity in VERO-6 cells, though its IC50 values in this context are greater than 20000.0 nM. Notably, the compound also shows inhibition in FRET-based protease assays with an IC50 of less than 0.02 µM. Overall, Chloranil is a versatile bioactive molecule with potential applications in combating diseases caused by different pathogens, including parasites and viruses, as well as being useful in enzymatic inhibition and cytotoxicity assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Chloranil (tetrachloro-p-benzoquinone) triggers inflammation and neurological dysfunction through Toll-like receptor 4 signaling and can be used to model inflammation in mice.
别名	四氯苯醌, p-Chloranil

化学信息

分子量	245.88
分子式	C₆Cl₄O₂
CAS No.	118-75-2
Smiles	ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O

储存&溶解度

存储

溶解度信息

DMSO: 50 mg/mL (203.35 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0670 mL	20.3351 mL	40.6702 mL	203.3512 mL
5 mM	0.8134 mL	4.0670 mL	8.1340 mL	40.6702 mL
10 mM	0.4067 mL	2.0335 mL	4.0670 mL	20.3351 mL
20 mM	0.2034 mL	1.0168 mL	2.0335 mL	10.1676 mL
50 mM	0.0813 mL	0.4067 mL	0.8134 mL	4.0670 mL
100 mM	0.0407 mL	0.2034 mL	0.4067 mL	2.0335 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

TLR4 Chloranil

Chloranil

Chloranil

Chloranil 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词