Name: HIF-1α-IN-8
Brand: TargetMol
SKU: T212496
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

产品介绍

生物活性

产品描述	HIF-1α-IN-8 is an orally active inhibitor of HIF-1α with an IC50 of 2.02 μM. It effectively suppresses the expression of inflammatory factors such as IL-6 and NO, reduces hypoxia-induced ROS production and apoptosis in C8-D1A cells, and inhibits the HIF-1α/IKKα/NF-κB signaling pathway. Additionally, it decreases the expression of proteins related to blood-brain barrier permeability. In a high-altitude cerebral edema (HACE) mouse model, HIF-1α-IN-8 lowers brain water content and oxidative stress levels. This compound is suitable for researching high-altitude cerebral edema (HACE).
靶点活性	HIF1α:2.02 μM
体外活性	HIF-1α-IN-8 (Compound N41) (20 μM, 48 h) 在 C8-D1A 细胞中抑制 IL-6 和 NO 炎症因子的分泌。HIF-1α-IN-8 (5-50 μM, 12 h) 可减少缺氧诱导的 ROS 产生并降低 C8-D1A 细胞的凋亡。HIF-1α-IN-8 (5-20 μM, 24 h) 抑制 HIF-1α/IKKα/NF-κB 信号通路中关键蛋白 (HIF-1α, IKKα, p65, IκBα) 的表达，以及降低与血脑屏障通透性相关的 MMP-9 和 AQP-4 蛋白在 C8-D1A 细胞中的表达。
体内活性	HIF-1α-IN-8 (Compound N41) (25-100 mg/kg，灌胃给药，每日一次，3 天) 可显著降低高海拔脑水肿 (HACE) 模型小鼠的脑水含量和氧化应激水平。