规格

价格

库存

数量

1 mg

¥ 219

现货

5 mg

¥ 531

现货

10 mg

¥ 851

现货

25 mg

¥ 1,330

现货

50 mg

¥ 2,150

现货

100 mg

¥ 3,290

现货

200 mg

¥ 4,730

现货

1 mL x 10 mM (in DMSO)

¥ 617

现货

生物活性

产品描述	Trans-Clovamide (trans-Clovamide) is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 µM) in several in vitro models of neuronal death. Trans-Clovamide is an excellent ROS and oxygen radical scavenger and also has anti-inflammatory and neuroprotective effects. Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi, and Heliobacter pylori.
体外活性	Clovamide在三种体外神经元死亡模型中保护神经元免受损伤：氧化应激、兴奋毒性和OGD/再氧化。在SH-SY5Y人类神经母细胞瘤细胞中，Clovamide (10-100 μM) 显著地保护细胞免于死亡，其EC50值为3.6 μM。Clovamide抑制可可中三种Phytophthora属病原体的生长，可作为可可多酚氧化酶的底物，是促成酶促褐变的贡献者。此外，Clovamide在体外抑制蛋白酶和果胶酶，并增强PPARγ表达。
别名	trans-Clovamide, N-trans-Caffeoy-L-dopa

化学信息

分子量	359.33
分子式	C₁₈H₁₇NO₇
CAS No.	53755-02-5
Smiles	OC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)\C=C\c1ccc(O)c(O)c1
密度	no data available
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 150 mg/mL (417.44 mM), Sonication and heating to 60℃ are recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.13 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO