Mcl-1-IN-16 is an effective macrolide inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki of less than 0.08 nM. It demonstrates over 50,000-fold selectivity for Mcl-1 compared to other anti-apoptotic Bcl-2 family members, Bcl-2 and Bcl-xL. Mcl-1-IN-16 activates caspase-3/7, thereby inducing apoptosis. In tumor xenograft mouse models derived from lung cancer, it achieves tumor regression. Mcl-1-IN-16 is useful for research on solid tumors, including non-small cell lung cancer (NSCLC).

MCL1:< 0.08 nM (Ki)