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Raptinal 直接激活 caspase-3 并在多种细胞系中启动内在的 caspase 依赖性细胞凋亡途径。


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Raptinal 直接激活 caspase-3 并在多种细胞系中启动内在的 caspase 依赖性细胞凋亡途径。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 569 | 现货 | |
| 5 mg | ¥ 1,320 | 现货 | |
| 10 mg | ¥ 1,880 | 现货 | |
| 25 mg | ¥ 2,670 | 现货 | |
| 50 mg | ¥ 3,480 | 现货 | |
| 100 mg | ¥ 4,690 | 现货 | |
| 200 mg | ¥ 6,570 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 1,450 | 现货 |
Raptinal 相关产品
| 产品描述 | Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines. |
| 体外活性 | In human gastric cancer cell lines AGS, MKN28, and MKN45, Raptinal(10 μM) induces the cleavage of pro-caspase-3 into the active form. Raptinal induces death against various cancer and non-cancerous cell lines (IC50 = 0.7-3.4 μM)[2]. |
| 体内活性 | In B16-F10 and 4T1 models, intraperitoneal administration of Raptinal (20 mg/kg) exerts anticancer activity. In C57BL/6 mice, intravenous administration of Raptinal (37.5 mg/kg) shows the peak plasma concentration and elimination half-life of 54.40.9 μg/mL and 92.1 minutes, respectively[2]. |
| 分子量 | 386.44 |
| 分子式 | C28H18O2 |
| CAS No. | 1176-09-6 |
| Smiles | O=CC1(c2ccccc2-c2ccccc12)C1(C=O)c2ccccc2-c2ccccc12 |
| 存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| 溶解度信息 | DMSO: 18.0 mg/mL (46.6 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||
| 体内实验配方 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.18 mM), Sonication is recommended. 请按顺序添加溶剂,在添加下一种溶剂之前,尽可能使溶液澄清。如有必要,可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考,体内配方并不是绝对的,请根据不同情况进行调整。 | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
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