Name: ESBA-105
Brand: TargetMol
SKU: T9901A-1362
Rating: 4.5 (1 reviews)

生物活性

产品描述	ESBA-105 represents a highly stable, humanized single-chain Fv (scFv) antibody fragment specifically engineered to target and neutralize human tumor necrosis factor-alpha (TNF-α) with exceptional binding affinity. It effectively facilitates the measurable blockade of TNF-mediated pro-inflammatory signaling and apoptosis across various preclinical experimental models to evaluate the optimization of tissue penetration and pharmacokinetic stability during strictly monitored laboratory observation periods and functional neutralization assays.
靶点活性	TNF-α:~150 - 200 pM
体外活性	在利用 L929 成纤维细胞进行的标准化中和实验中，ESBA-105 以剂量依赖方式抑制了由 TNF-alpha 诱导的细胞毒性 [1]。
体内活性	在兔眼部给药模型中，通过局部给药方式给予 ESBA-105，实验结果显示其在组织中快速分布并在前房和玻璃体腔内达到了治疗浓度 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P01375
靶点	TNFSF2/TNFa

储存&溶解度

存储

ESBA-105