XSJ-10 is an HDAC inhibitor containing a RAS/RAF protein interference unit, with IC50 values of 0.05 μM in PANC-1 cells and 0.04 μM in HT-29 cells. It effectively induces cancer cell apoptosis and tumor inhibition by strongly suppressing the RAS-RAF-MEK-ERK signaling pathway and HDAC3 acetylation levels.

HDAC6:67.04 nM, HDAC10:77.55 nM, HDAC8:88.64 nM, HDAC11:72.54 nM, HDAC1:11.37 nM, HDAC2:9.97 nM, HDAC5:75.14 nM, HDAC3:8.97 nM, HDAC9:83.67 nM, HDAC4:75.05 nM, HDAC7:121.28 nM