Name: ACA-28
Brand: TargetMol
SKU: T60821
Price: 745 CNY
Availability: InStock
Rating: 5 (10 reviews)

ACA-28

很棒

产品编号 T60821Cas号 948044-25-5

别名 G1T28

ACA-28是一种ERK MAPK信号调节剂，能够过度激活ERK从而诱导黑黑色素瘤细胞凋亡，对黑色素瘤细胞 (SK-MEL-28) 和正常黑色素细胞 (NHEM)的IC50值分别为5.3和10.1μM。

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规格

价格

库存

数量

1 mg

¥ 745

In stock

5 mg

¥ 2,480

In stock

10 mg

¥ 3,930

In stock

25 mg

¥ 6,330

In stock

50 mg

¥ 8,530

In stock

100 mg

¥ 11,500

In stock

200 mg

¥ 15,500

In stock

1 mL x 10 mM (in DMSO)

¥ 1,730

In stock

产品介绍

生物活性

产品描述	ACA-28 is an ERK MAPK signalling modulator that induces apoptosis in melanoma cells by overexpressing ERK. Its IC₅₀ values for melanoma cells (SK-MEL-28) and normal melanocytes (NHEM) are 5.3 and 10.1 μM respectively.
靶点活性	SK-MEL-28 cells:5.3 μM, NHEM:10.1 μM
体外活性	方法：ACA-28(0-10μM)处理A4-15细胞，通过WST-8和Western blot检测细胞增殖和相关蛋白表达水平。结果：ACA-28选择性下调DUSP6并抑制A4-15细胞生长。[2]
别名	G1T28

化学信息

分子量	316.31
分子式	C₁₇H₁₆O₆
CAS No.	948044-25-5
Smiles	C(OC(OC)=O)(C1=CC=C(OC(OC)=O)C=C1)C2=CC=CC=C2
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (252.92 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1615 mL	15.8073 mL	31.6146 mL	158.0728 mL
5 mM	0.6323 mL	3.1615 mL	6.3229 mL	31.6146 mL
10 mM	0.3161 mL	1.5807 mL	3.1615 mL	15.8073 mL
20 mM	0.1581 mL	0.7904 mL	1.5807 mL	7.9036 mL
50 mM	0.0632 mL	0.3161 mL	0.6323 mL	3.1615 mL
100 mM	0.0316 mL	0.1581 mL	0.3161 mL	1.5807 mL

体内实验配液计算器