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顶部相关产品产品介绍化学信息储存和溶解信息计算器

4-Methylhistamine hydrochloride

货号 T50049Cas号 84103-51-5 一键复制产品信息纯度: 95%
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4-Methylhistamine hydrochloride 已被证明能抑制铜依赖性酶如酪氨酸酶和多巴胺β-羟化酶的活性，还被证明可以调节参与细胞周期调节和凋亡的基因的表达。

4-Methylhistamine hydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 95%

货号 T50049Cas号 84103-51-5

4-Methylhistamine hydrochloride 已被证明能抑制铜依赖性酶如酪氨酸酶和多巴胺β-羟化酶的活性，还被证明可以调节参与细胞周期调节和凋亡的基因的表达。

4-Methylhistamine hydrochloride
规格价格库存数量
1 mg
¥ 356
现货
5 mg
¥ 822
现货
10 mg
¥ 1,190
现货
25 mg
¥ 2,100
现货
50 mg
¥ 2,980
现货
100 mg
¥ 4,330
现货
1 mL x 10 mM (in DMSO)
¥ 580
现货
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纯度: 95%
颜色: 黄色
性状: Solid
资源下载: COA HNMR产品操作手册

产品介绍

4-Methylhistamine hydrochloride AI Summary
4-Methylhistamine hydrochloride exhibits a multifaceted bioactivity profile. It demonstrates in vivo agonist activity at the histamine H2 receptor in rats, effectively stimulating gastric acid secretion. In vitro, it acts as an agonist at the histamine H1 receptor in guinea pig ileum, albeit to a much lower extent. Cell viability assays indicate that 4-Methylhistamine hydrochloride promotes positive growth rates in HEK293T cells, human fibroblasts, and some U2OS cells, but negatively affects growth rates in other U2OS cell assays, suggesting cell type-dependent bioactivity. Thermal stability assays reveal that the compound has varying effects on the melting temperatures of different protein domains, decreasing TM in some by up to -2.22 degrees Celsius and increasing it by up to 1.12 degrees Celsius in others. Additionally, GPCR beta-arrestin recruitment assays show that 4-Methylhistamine hydrochloride exerts inhibitory effects on several targets including ADGRF1, FFAR4, and ADRB2, with inhibition ranging from -36.82% to -0.04%, while also stimulating targets such as CX3CR1 and GPR119, with maximum stimulation reaching up to 27.94%. Furthermore, the compound has been characterized using thin layer chromatography, demonstrating specific retardation factors using different solvent systems. This diverse bioactivity suggests that 4-Methylhistamine hydrochloride has complex pharmacological properties and interacts differentially across various biological targets and conditions..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
4-Methylhistamine hydrochloride has been shown to inhibit the activity of copper-dependent enzymes such as tyrosinase and dopamine beta-hydroxylase and has also been shown to modulate the expression of genes involved in cell cycle regulation and apoptosis.
化学信息
分子量161.633
分子式C6H12ClN3
CAS No.84103-51-5
SmilesCl.CC1=C(CCN)NC=N1
密度no data available
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
DMSO: 55 mg/mL (340.28 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM6.1869 mL30.9343 mL61.8686 mL309.3428 mL
5 mM1.2374 mL6.1869 mL12.3737 mL61.8686 mL
10 mM0.6187 mL3.0934 mL6.1869 mL30.9343 mL
20 mM0.3093 mL1.5467 mL3.0934 mL15.4671 mL
50 mM0.1237 mL0.6187 mL1.2374 mL6.1869 mL
100 mM0.0619 mL0.3093 mL0.6187 mL3.0934 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

4-Methylhistamine Hydrochloride2(5methyl1Himidazol4yl)ethan1amine hydrochloride2 (5 methyl 1H imidazol 4 yl)ethan 1 amine hydrochloride
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