191
122
3
2
11
Cat. No. | Product Name | ||
---|---|---|---|
L7900 | 成骨分子库 | 317 compounds | |
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L4800 | 血管生成库 | 1353 compounds | |
1353 个高潜力的抑制或促进血管生成的小分子集合,可用于药物靶点开发、血管生成机理研究的高通量筛选,高内涵筛选; | |||
L7100 | 抗肥胖化合物库 | 2247 compounds | |
2247 个抗肥胖化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
CL0090 |
RNA Synthesis inhibitor/activator kit
RNA Synthesis inhibitor/activator kit |
||
CL0073 |
DNA synthesis inhibitor/activator kit
DNA synthesis inhibitor/activator kit |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11234 |
ESI-08
|
cAMP | GPCR/G Protein |
ESI-08 是 EPAC2 的有效拮抗剂,IC50 为 8.4 μM。 ESI-08 特异性阻断 cAMP 诱导的 EPAC 活化,但不阻断 cAMP 介导的 PKA 活化。 | |||
T2244 |
ESI-09
|
cAMP; Virus Protease | GPCR/G Protein; Microbiology/Virology |
ESI-09是一种新型非环状核苷酸EPAC 的拮抗剂,对EPAC1和EPAC2的IC50值分别为3.2和1.4 μM。 | |||
T15247 |
ESI-05
NSC 116966 |
cAMP | GPCR/G Protein |
ESI-05 (NSC-116966) 是特异性的 cAMP 直接激活交换蛋白 2 (EPAC2) 拮抗剂(IC50:0.4 µM),能够抑制 cAMP 诱导的 EPAC2 的活化,并 EAPC2 介导的 Rap1 的活化。 | |||
T76831 |
Tesidolumab
LFG316 |
Complement System | Immunology/Inflammation |
Tesidolumab (LFG316) 是一种全人IgG1/λ抗c5单克隆抗体。Tesidolumab (LFG316)对crovalimab和C5有抑制作用, 阻断C5的切割,防止膜攻击复合体的后续形成,可用于研究血管外溶血。 | |||
T9379 |
L-Threonic acid magnesium salt
|
Others | Others |
L-Threonic acid magnesium salt 可增加老年大鼠和晚期阿尔茨海默病 (AD) 模型小鼠的突触密度和记忆能力。 | |||
T9978 |
Glutathione synthesis-IN-1
|
Others | Others |
Glutathione synthesis-IN-1 (DC-1)是谷胱甘肽合成抑制剂。 | |||
T39994 |
Sovilnesib
|
Microtubule Associated | Cytoskeletal Signaling |
Sovilnesib 是一种有效kinesin-like protein KIF18A 抑制剂。它可用于癌症的研究。 | |||
T3597 |
Cutamesine dihydrochloride
AGY94806 dihydrochloride,库他美新二盐酸盐,SA4503 (dihydrochloride),SA4503 dihydrochloride |
Sigma receptor | GPCR/G Protein |
Cutamesine dihydrochloride (SA4503 dihydrochloride) 是一种选择性 σ1 受体激动剂,IC50值为 17.4 nM。 | |||
T6964 |
Resiquimod
R848,雷西莫特,S28463 |
HCV Protease; TLR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂,可诱导细胞因子上调。 | |||
T6875 |
Lesinurad
RDEA594,雷西那德,来司诺雷 |
OAT | Membrane transporter/Ion channel |
Lesinurad (RDEA594) 是URAT1和OAT 抑制剂。Lesinurad 用作肾转运蛋白OAT1 和OAT3 的底物,Km 分别为 0.85 和 2 μM。 | |||
T2686 |
Esomeprazole Magnesium
(S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium |
ATPase; Proton pump | Membrane transporter/Ion channel |
Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T67822L |
Ulodesine
BCX4208 |
Endogenous Metabolite | Metabolism |
Ulodesine (BCX4208) 是一种嘌呤核苷磷酸化酶 (PNP) 抑制剂,对 PNP 有抑制作用,IC50 值为 2.293 nM/L。Ulodesine 可用于研究高尿酸血症。 | |||
T3712 |
Mivebresib
ABBV-075,米维布塞 |
Apoptosis; Epigenetic Reader Domain | Apoptosis; Chromatin/Epigenetic |
Mivebresib (ABBV-075) 是一种有效的,口服活性的溴结构域和末端结构域 (BET) 抑制剂,结合BRD4的Ki 值是 1.5 nM。 | |||
T7780 |
Blarcamesine
AE-37,AVex-73 |
AChR | Neuroscience |
Blarcamesine (AVex-73) 是一种毒蕈碱 M1 激动剂,具有抗惊厥、抗失忆、神经保护和抗抑郁的特性,可能用于治疗阿尔茨海默病。 | |||
T7766 |
Remdesivir
瑞德西韦,GS-5734 |
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Remdesivir (GS-5734) 是一种核苷类似物,一种广谱的抗病毒化合物,通过抑制病毒的 RNA 依赖性 RNA 聚合酶发挥活性。Remdesivir 对埃博拉病毒、SARS 病毒、MERS病毒等均有活性,对 COVID-19 有潜在治疗价值。 | |||
T4507 |
Chlorphenesin
Adermykon,Chlorophenesin,Gecophen,氯苯甘醚 |
Antibacterial; Antifungal; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Chlorphenesin (Chlorophenesin) 是一种抗原相关免疫抑制剂,可抑制 IgE 介导的组胺释放。 它也用作抗真菌剂,用于许多眼保健化妆品中。 | |||
T3258 |
Ponesimod
ACT-128800 |
S1P Receptor; LPL Receptor | GPCR/G Protein |
Ponesimod (ACT-128800) 是一种选择性 S1P1可口服激动剂,在放射性配体结合试验中的 IC50值为 6 nM。它可高效激活 S1P1介导的信号转导,EC50为5.7 nM。它可预防淋巴细胞介导的组织炎症,具有潜在的免疫调节活性。 | |||
T8391 |
Cesium chloride
氯化铯,CsCl |
Potassium Channel | Membrane transporter/Ion channel |
Cesium chloride (CsCl) 是一种钾通道抑制剂,可以防止 Alloxan 引起的 Na+转运减少。Cesium chloride 可以诱发心律失常。 | |||
T36395 |
Trotabresib
CC-90010 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
Trotabresib (CC-90010) 是一种具有口服活性的 BET 抑制剂,可用于晚期实体瘤的研究。 | |||
T15337 |
Forodesine
呋咯地辛,BCX-1777,Immucillin-H |
Others | Others |
Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine is an orally active inhibitor of purine nucleoside phosphorylase (IC50s: 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP). It could induce apoptosis in leukemic cells b | |||
T4111 |
Blarcamesine hydrochloride
Anavex 2-73,AVex-73 hydrochloride,AE-37 hydrochloride |
Sigma receptor | GPCR/G Protein |
Blarcamesine hydrochloride (AVex-73 hydrochloride) 是一个sigma-1受体激动剂,IC50值为 860 nM。 | |||
T8495 |
Alobresib
Vorolanib,GS-5829 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
Alobresib (Vorolanib) 是一种BET 溴结构域抑制剂,是一种抗肿瘤候选药物。 | |||
T26778 |
Besipirdine
HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493 |
Sodium Channel; Adrenergic Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Besipirdine (HP 749 free base)是一种非受体依赖性拟胆碱化合物,具有α-肾上腺素能活性和心血管活性。Besipirdine 抑制电压依赖性钠钾通道,抑制生物胺的摄取。Besipirdine 可减少大鼠的时间表诱导的烦渴,增强中枢神经系统中的胆碱能和肾上腺素能神经传递。 | |||
TP1281L1 |
Bombesin acetate(31362-50-2 free base)
|
Bombesin Receptor | GPCR/G Protein |
Bombesin acetate(31362-50-2 free base) 是一种 14 个氨基酸的肽,是从欧洲火腹蟾蜍 (Bombina bombina) 的皮肤中分离出来的。它在哺乳动物中有两个已知的同源物,称为神经调节蛋白 B 和胃泌素释放肽。 | |||
TP1916L1 |
[D-Phe12,Leu14]-Bombesin acetate
[D-Phe12,Leu14]-Bombesin acetate(108437-88-3 Free base) |
Bombesin Receptor | GPCR/G Protein |
[D-Phe12,Leu14]-Bombesin acetate 抑制铃蟾素刺激的分泌。 | |||
TP2219L |
Alytesin acetate
|
Others | Others |
Alytesin acetate 是一种两栖类铃蟾肽样肽。 | |||
TP2239L |
[D-Phe12]-Bombesin acetate
[D-Phe12]-Bombesin acetate(108437-87-2 free base) |
Bombesin Receptor | GPCR/G Protein |
[D-Phe12]-Bombesin acetate 抑制铃蟾素刺激的分泌。 | |||
T1418 |
Bucladesine sodium
dbcAMP,Dibutyryl-cAMP sodium salt,布拉地新钠盐,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt |
PKA; PDE | Metabolism; Tyrosine Kinase/Adaptors |
Bucladesine sodium (DC2797) 是一种 cAMP 类似物,具有细胞渗透性。Bucladesine sodium 也是一种 cAMP 依赖性的蛋白激酶 (PKA) 激活剂,一种磷酸二酯 (PDE) 抑制剂。Bucladesine sodium 具有抗炎活性。 | |||
T6405 |
Bepotastine Besilate
Talion,TAU 284,苯磺酸贝托司汀,Bepreve,Bepotastine Beslilate |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Bepotastine Besilate (TAU 284) 是一种选择性可口服的组胺 H1 受体拮抗剂,可用于过敏性鼻炎、过敏性结膜炎、荨麻疹和瘙痒症的研究。 | |||
T0991 |
Desipramine hydrochloride
NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020 |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药,可作为选择性去甲肾上腺素再摄取抑制剂。 它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。 | |||
T4512 |
Magnesium glycinate
magnesium 2-aminoacetate,Magnesium diglycinate,甘氨酸镁 |
Others | Others |
Magnesium glycinate (magnesium 2-aminoacetate) 是一种营养补充剂,是甘氨酸的镁盐,具有良好的理化性质和生物活性。Magnesium 是人体必需的矿物质,参与能量代谢过程,协助维持正常的肌肉功能,对人体起着至关重要的作用。 | |||
T0015 |
Mephenesin
Cresoxydiol,甲酚甘油醚,Memphenesin,Mephedan,Decontractyl |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Mephenesin (Cresoxydiol) 是 NMDA 受体拮抗剂,也是中枢性肌松弛剂。 | |||
TQ0318 |
Filanesib
ARRY-520,ARRY 520 |
KSP | Cell Cycle/Checkpoint |
Filanesib (ARRY 520) 是一种选择性的驱动蛋白纺锤体蛋白(KSP)的抑制剂(IC50 = 6 nM),具有强大的抗增殖活性。 | |||
T12834 |
Saroglitazar Magnesium
|
Others | Others |
Saroglitazar Magnesium 是一种新型过氧化物酶体增殖物激活受体(PPAR)激动剂,对PPARα (EC50 0.65pM)具有显著的激活活性以及对PPARγ(EC50 3 nM)有中等的激活活性。 | |||
T2103 |
Ispinesib
伊匹尼塞,伊斯平斯,CK0238273,SB-715992 |
Apoptosis; Kinesin; KSP | Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling |
Ispinesib (SB-715992) 是一种选择性可逆的驱动蛋白纺锤体蛋白抑制剂,具有抗肿瘤特性。 | |||
T8386 |
Esomeprazole Magnesium trihydrate
埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate |
Proton pump | Membrane transporter/Ion channel |
Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T1885 |
Siramesine hydrochloride
Lu 28-179 hydrochloride,西拉美新盐酸盐 |
Ferroptosis; Sigma receptor; lysosomal autophagy | Apoptosis; Autophagy; GPCR/G Protein |
Siramesine hydrochloride (Lu 28-179 hydrochloride) 是一种选择性 sigma-2 受体激动剂,可引发 Y 细胞的细胞死亡并在体内表现出有效的抗癌活性。Siramesine 对 sigma-2 受体具有亚纳摩尔亲和力,并且对 sigma-2 受体的选择性是 sigma-1 受体的 140 倍。 | |||
T1906 |
Molibresib
GSK 525762A,GSK525762,(4S)-6-(4-氯苯基)-N-乙基-8-甲氧基-1-甲基-4H-[1,2,4]三唑并[4,3-a][1,4]苯并二氮杂卓-4-乙酰胺,I-BET 762 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
Molibresib (GSK525762) 是一种 BET 溴结构域抑制剂,IC50为32.5在42.5 nM 之间。 | |||
T40864 |
Magnesium sulfate
|
Others | Others |
Magnesium sulfate 是目前预防和控制子痫发作的抗惊厥剂。Magnesium sulfate 也被广泛用作宫缩剂。 | |||
T67817 |
Besifovir PM
LB80331 PM |
HBV | Microbiology/Virology |
Besifovir PM (LB80331 PM) 是Besifovir 的类似物。Besifovir 是一种新型可口服的无环核苷酸膦酸酯,可治疗慢性乙型肝炎感染。 | |||
TP1153L |
Fibronectin Adhesion-promoting Peptide acetate
Fibronectin Adhesion-promoting Peptide acetate(125720-21-0 free base),Heparin Binding Peptide acetate |
Others | Others |
Fibronectin Adhesion-promoting Peptide acetate (Heparin Binding Peptide acetate)(125720-21-0 free base) 是在纤连蛋白的羧基末端肝素结合结构域中发现的肝素结合氨基酸序列之一。 | |||
T6406 |
Besifloxacin Hydrochloride
BOL-303224-A,Besivance hydrochloride,Besifloxacin HCl,盐酸贝西沙星 |
Antibacterial; Antibiotic | Microbiology/Virology |
Besifloxacin Hydrochloride (BOL-303224-A) 是一种氟喹诺酮类抗生素。 | |||
T19389 |
L-Ascorbic acid 2-phosphate magnesium
2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁 |
Phosphatase; Phosphorylase | Metabolism |
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 是长效的维生素 C 衍生物,能够以刺激胶原蛋白的表达和形成。它提高成骨细胞分化过程中 hASC 中的碱性磷酸酶特性和 runx2A 的表达。它能够以作为培养基补充人脂肪干细胞的成骨分化。 | |||
T65281 |
Magnesium acetate tetrahydrate
|
Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
Magnesium acetate tetrahydrate 是无水醋酸镁盐的水合形式。Magnesium acetate tetrahydrate 常用来合成其他化合物,可作为电解质补充剂或分子生物学实验中的试剂。 | |||
T5939 |
Calcium dobesilate
|
Apoptosis; Others | Apoptosis; Others |
Calcium dobesilate 具有血管保护特性,部分通过改善 HG 诱导的炎症来保护内皮细胞,用于慢性静脉疾病、糖尿病视网膜病变以及痔疮发作等研究。 | |||
T5832 |
Besifovir
|
HBV | Microbiology/Virology |
Besifovir 是由 LB80380 转化而来的一种 LB80380 母体药物,进一步代谢为其活性形式 LB80317。LB80380 是抗乙型肝炎病毒的抗病毒药物。 | |||
T10491 |
Galidesivir
BCX4430,Immucillin-A |
Others | Others |
Galidesivir (BCX4430) 是一种广谱抗病毒化合物,是一种腺苷类似物,能抑制病毒 RNA 依赖的 RNA 聚合酶 (RdRp) 活性。Galidesivir 在体外对多种 RNA 病毒病原体有抑制作用,可减少受感染动物的肺部感染。 | |||
T12399 |
Peldesine
BCX 34 |
Nucleoside Antimetabolite/Analog; HIV Protease | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
Peldesine (BCX 34) 是一种有效的、竞争性的、可逆的和口服活性的嘌呤核苷磷酸化酶抑制剂。 Peldesine 抑制 T 细胞增殖,IC50 为 800 nM。 Peldesine 可用于皮肤 T 细胞淋巴瘤、牛皮癣和 HIV 感染的研究。 | |||
T26778L |
Besipirdine hydrochloride
HP 749 hydrochloride,Besipirdine hydrochloride(119257-34-0 Free base) |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Besipirdine hydrochloride 是一种非受体依赖性拟胆碱化合物,具有α-肾上腺素能活性和心血管活性。Besipirdine hydrochloride 抑制电压依赖性钠钾通道,抑制生物胺的摄取。Besipirdine hydrochloride 可减少大鼠的时间表诱导的烦渴,增强中枢神经系统中的胆碱能和肾上腺素能神经传递。 | |||
T7882 |
Indomethacin farnesil
吲哚美辛法呢酯,Infree |
Others; COX; Autophagy | Autophagy; Immunology/Inflammation; Neuroscience; Others |
Indomethacin farnesil (Infree) 是具有口服活性的 Indomethacin 前药,可通过干扰溶酶体的正常功能来破坏自噬流,有抗炎和抗风湿作用。它是一种可透过血脑屏障的,非选择性的 COX1和 COX2抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 18 nM 和 26 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S0488 |
Syringaresinol diglucoside
Syringaresinol-di-O-glucoside,丁香树脂醇双葡萄糖苷 |
Others | Others |
Syringaresinol diglucoside (Syringaresinol-di-O-glucoside) 是一种提取自竹叶中的天然化合物。 | |||
T8179 |
Aloeresin D
芦荟新甙D,芦荟新苷 D |
Beta-Secretase; BACE | Neuroscience |
Aloeresin D 是一种从芦荟中分离得到的色原酮苷,能够抑制 β-分泌酶活性,IC50=39 μM。 | |||
TN1782 |
(+)-Isolariciresinol
(+)-Cyclolariciresinol,Isolariciresinol |
Immunology/Inflammation related | Immunology/Inflammation |
(+)-Isolariciresinol ((+)-Cyclolariciresinol) 从板蓝根中提取,具有抗氧化和抗炎活性,可用于风湿病研究。 | |||
T3S1265 |
Liriopesides B
山麦冬皂苷B,Nolinospiroside F |
Others | Others |
Liriopesides B (Nolinospiroside F) 是一种甾体皂苷,分离自 Ophiopogon japonicas 中,具有抗氧化和抗衰老活性。 | |||
T5S2178 |
Fargesin
辛夷脂素,(+/-)-Fargesin |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Fargesin ((+/-)-Fargesin) 是一种活性新木脂素,从木兰植物中分离得到,具有抗高血压和抗炎活性。 | |||
T5759 |
S-(+)-Marmesin
(+)-Marmesin,异紫花前胡内酯,(S)-Marmesin,marmesin |
Lipoxygenase; COX | Immunology/Inflammation; Metabolism; Neuroscience |
S-(+)-Marmesin (marmesin) 是一种从木橘成熟树皮中分离得到的香豆素,具有 COX-2/5-LOX 双重抑制活性。 | |||
T5755 |
Aloesin
|
Tyrosinase | Proteases/Proteasome |
Aloesin 是芦荟的活性成分之一,能够通过 MAPK 信号通路发挥抗癌作用,并具有抗炎、紫外线保护和抗菌作用。 | |||
T21820 |
Resistomycin
Geliomycin,Heliomycin |
Antibiotic | Microbiology/Virology |
Resistomycin(Geliomycin),一种五环多酮类抗生素,通过触发凋亡展现出强大的抗癌特性。 | |||
T3415 |
Secoisolariciresinol diglucoside
亚麻木酚素,LGM2605 |
ROS | Immunology/Inflammation |
Secoisolariciresinol diglucoside (LGM2605) 在铁过载诱导的氧化还原炎症损伤的体外模型中具有细胞保护作用。 Secoisolariciresinol Diglucoside(25 mg/kg b.w.) 通过抑制 ROS 水平介导的酶和非酶抗氧化剂水平升高来防止肝脏受到过氧化损伤,从而发挥抗高血糖作用。 | |||
TN1916 |
Matairesinol
罗汉松树脂酚 |
ATPase; p38 MAPK; ROS | Immunology/Inflammation; MAPK; Membrane transporter/Ion channel |
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells. | |||
TMS0484 |
Episyringaresinol 4'-O-β-D-glncopyranoside
(-)-丁香树脂酚-4-O-β-D-葡萄糖苷,(-)-Syringaresinol 4-O-β-D-glucopyranosi |
Others | Others |
Episyringaresinol 4'-O-β-D-glncopyranoside ((-)-Syringaresinol 4-O-β-D-glucopyranosi) 是一种天然的潜在神经炎症抑制剂,分离自鼠尾草 (Alhagi sparsifoliaShap) 。 | |||
T0739 |
Guaifenesin
Glycerol guaiacolate,Guaiacol glyceryl ether,愈创甘油醚,Guaiphenesin |
Others | Others |
Guaifenesin (Guaiphenesin) 是一种祛痰剂,来自于 Guajacum officinale Linné 木材中。它可以增加痰液体积和降低其粘度,缓解咳嗽不适,促进有效的咳嗽。 | |||
TN4510 |
(+)-Medioresinol Di-O-β-D-glucopyranoside
(+)-Mediresinol Di-O-beta-D-glucopyranoside,(+)-Medioresinol Di-O-β-D-glucopyranoside |
PDE | Metabolism |
(+)-Medioresinol Di-O-β-D-glucopyranoside 对环 AMP 磷酸二酯酶具有很强的抑制活性。 | |||
TN2080 |
Pinoresinol
松脂酚,松脂素,(+)-Pinoresinol |
Apoptosis; NF-κB; CDK; p53 | Apoptosis; Cell Cycle/Checkpoint; NF-κB |
Pinoresinol ((+)-Pinoresinol) 是一种植物来源的木质素,具有抗炎、保肝和杀真菌活性。它导致 CDK 抑制剂 p21(WAF1/Cip1) 在 mRNA 和蛋白质水平上调,抑制 NF-kappaB 和激活蛋白 1 。 | |||
T6S0535 |
Pinoresinol diglucoside
Pinoresinol Diglucopyranoside,松脂醇二葡萄糖苷 |
Glucosidase | Metabolism |
Pinoresinol diglucoside (Pinoresinol Diglucopyranoside) 是一种分离自杜仲和其他植物物种中的主要木脂素,具有多种药理活性。 | |||
TN2197 |
Secoisolariciresinol
|
TNF | Apoptosis |
Secoisolariciresinol 是一种属于苯丙素类的木脂素。 | |||
T34295 |
Resiniferatoxin
RTX,[3H]resiniferatoxin,树脂毒素 |
IL Receptor | Immunology/Inflammation |
Resiniferatoxin ([3H]resiniferatoxin) 抑制 Th1 细胞因子的产生,有助于防御 T.spiralis 感染,并可用于免疫反应调节剂的研究。 | |||
T20793 |
Magnesium Lithospermate B
丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B |
Others | Others |
Magnesium Lithospermate B 是一种咖啡酸四聚体的衍生物,从Salviae miltiorrhizae 中提取得到。它能够抑制神经炎症并减轻神经变性。它被广泛用于心血管疾病的研究,并且可以防止葡萄糖引起的细胞内氧化损伤。 | |||
T22455 |
Vindesine sulfate
DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS |
Others | Others |
Vindesine sulfate (Desacetyl Vinblastine amide) 是一种长春花生物碱,它是长春碱的合成衍生物,与有丝分裂纺锤体的微管蛋白结合,导致微管结晶和有丝分裂停滞或细胞死亡。 | |||
TP2223 |
Beesioside Q
|
Others | Others |
Beesioside Q 是从铁破锣 Beesia calthaefolia (Maxim.) Ulbr 的根茎中提取出来的天然产物。 | |||
TN1594 |
DL-Syringaresinol
(±)-Syringaresinol |
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素,具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化,通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。 | |||
T13739 |
Isopropylidenylacetyl-marmesin
异紫花前胡内酯异戊烯酸酯,(±)-Prantschimgin,Prantschimgin |
Others | Others |
Isopropylidenylacetyl-marmesin (Prantschimgin) 是一种源自羌活 Notopterygium incisum 和 Ferulago bracteata 根的天然产物。 | |||
TN1853 |
Lariciresinol
(+)-落叶松树脂醇 |
VEGFR; Antifection | Angiogenesis; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Lariciresinol 是一种肠木脂素前体,它通过破坏真菌质膜具有杀真菌活性,并具有作为治疗人类真菌感染性疾病的新型抗真菌剂的治疗潜力。膳食 lariciresinol 可以减缓乳腺肿瘤的生长并降低人 MCF-7 乳腺癌异种移植物和致癌物诱导的大鼠乳腺肿瘤的血管密度。 | |||
TN2079 |
(-)-Pinoresinol
|
Others; TNF; NF-κB; COX | Apoptosis; Immunology/Inflammation; Neuroscience; NF-κB; Others |
(-)-Pinoresinol 是从 Serissa japonica (Thunb.) Thunb 的全植物中分离得到的天然产物。 | |||
TJS0487 |
(-)-Syringaresinol
DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素 |
Others | Others |
(-)-Syringaresinol (DL-Syringaresinol) 来源于番荔枝 Annona Montana 的茎。 (-)-Syringaresinol 通过 G1 期阻滞和诱导细胞凋亡来抑制人早幼粒细胞 HL-60 细胞的增殖,并具有抗癌活性。 | |||
T4S0792 |
Pinoresinol 4-O-β-D-glucopyranoside
(+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside |
Others | Others |
(+)-pinoresinol-β-D-glucoside; (+)-pinor 是连翘中主要的活性呋喃类木脂素。它显示出抗氧化、降血压和环磷酸腺苷 (cAMP) 磷酸二酯酶抑制活性。 | |||
T4A2458 |
Resibufogenin
酯蟾毒配基,Bufogenin,Recibufogenin,酯蟾毒配基,蟾力苏 |
Others | Others |
Resibufogenin (Bufogenin) 是华蟾素的成分之一,表现出抑制氧化应激及肿瘤再生的活性。 | |||
T2S0531 |
Pinoresinol dimethyl ether
(+)-Eudesmin,松脂素二甲醚 |
Others; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Others |
Pinoresinol dimethyl ether 是一种非酚性呋喃木质素,从 Magnolia kobus 茎皮中分离得到,具有神经活性。它可刺激上游 MAPK、PKC 和 PKA 通路,诱导 PC12 细胞神经突起生长。 | |||
T9425 |
Epipinoresinol-4'-O-β-D-glucoside
|
Others | Others |
Simplocosin 是一种葡萄糖苷类化合物。 | |||
T19281L |
Dihydroxyacetone phosphate hemimagnesium salt hydrate
Dihydroxyacetone phosphate hemimagnesium salt hydrate(57-04-5 free base) |
Others | Others |
Dihydroxyacetone phosphate hemimagnesium salt hydrate 也称为磷酸二羟基丙酮或 3-羟基-2-氧代丙基磷酸。 Dihydroxyacetone phosphate hemimagnesium salt hydrate 存在于从细菌到人类的所有生物中。在人类体内, Dihydroxyacetone phosphate hemimagnesium salt hydrate参与许多酶促反应。 Dihydroxyacetone phosphate hemimagnesium salt hydrate 已被研究用于治疗淋巴瘤、大细胞淋巴瘤、弥漫性淋巴瘤。 | |||
TN5438 |
Lariciresinol p-coumarate
(+)-Lariciresinol 9'-p-coumarate |
||
Lariciresinol p-coumarate 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5438,CAS号为 864452-88-0。 | |||
TN3127 | 5'-Methoxylariciresinol | Others | Others |
5'-Methoxylariciresinol is a natural product from Stellera chamaejasme. | |||
TMA0627 | Taxiresinol | TNF | Apoptosis |
Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice. | |||
TN3355 | Agatharesinol acetonide | Antifection | Microbiology/Virology |
Agatharesinol acetonide shows anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM). | |||
TN5425 |
(-)-Episyringaresinol
(-)-表丁香脂素,(-)-Lirioresinol A |
||
(-)-Episyringaresinol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5425,CAS号为 6216-82-6。 | |||
T24117 |
Guineesine
Pipyahyine |
||
Guineesine is an Acyl-CoA. It acts by inhibiting cholesterol acyltransferase. | |||
TN4305 |
(+)-Isolariciresinol 9'-O-glucoside
|
||
(+)-Isolariciresinol 9'-O-glucoside 是一种木脂素糖苷,可从数种植物中分离得到的。 | |||
T79961 |
Aloeresin G
|
||
Aloeresin G, 分离自Aloe的一种色原酮苷,对TNFα诱导的NF-κB转录活性具有抑制效果,其IC 50为40.02 μM。 | |||
TN1332 |
7-O-Methylaloeresin A
7-O-甲基芦荟新甙A,7-O-甲基片木素A |
BACE | Neuroscience |
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE. | |||
TN5427 |
Matairesinol monoglucoside
异罗汉松脂苷,Isomatairesinoside |
||
Matairesinol monoglucoside 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5427,CAS号为 34446-06-5。 | |||
TN3326 |
9-O-Feruloyllariciresinol
|
Others | Others |
9-O-Feruloyllariciresinol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3326,CAS号为 60337-67-9。 | |||
TN5651 |
3-O-Methylducheside A
3,8-Di-O-methylellagic acid 2-O-xyloside |
||
3-O-Methylducheside A 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5651,CAS号为 62218-23-9。 | |||
TN1351 |
9-O-Acetyl-4,4'-di-O-methyllariciresinol
|
Others | Others |
9-O-Acetyl-4,4'-di-O-methyllariciresinol is a natural product | |||
TN4412 |
Lariciresinol acetate
|
Others | Others |
Lariciresinol acetate 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4412,CAS号为 79114-77-5。 | |||
TN3265 |
Yuehgesin C
8-(3-Ethoxy-2-hydroxy-3-methylbutyl)-7-methoxycoumarin |
Others | Others |
Yuehgesin C 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3265,CAS号为 125072-68-6。 | |||
TN3126 |
5-Methoxyisolariciresinol
|
Others | Others |
(+)-5-Methoxyisolariciresinol displays significant antioxidant activities, with the IC(50) value in the range of ca. 42 to 49 microg/ml. | |||
TN3079 | 5,5'-Dimethoxysecoisolariciresinol | Others | Others |
5,5'-Dimethoxysecoisolariciresinol is a natural product from Podocarpus spicata. | |||
TN2386 | (±)-Lariciresinol | Others | Others |
(±)-Lariciresinol is a natural product from plants | |||
TN5641 |
3,7-Di-O-methylducheside A
3,7,8-Tri-O-methylellagic acid 2-O-xyloside |
||
3,7-Di-O-methylducheside A 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5641,CAS号为 136133-08-9。 | |||
TN4506 | (+)-Matairesinol | Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
(+)-Matairesinol exhibits immunomodulatory activity; it also shows inhibition of the discoloration of yellowtail dark muscle. | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01909 |
Elafin Protein, Human, Recombinant (His)
WAP3,ESI,peptidase inhibitor 3,SKALP,cementoin,MGC1... |
Human | HEK293 Cells |
Elafin, also known as Elastase-specific inhibitor, Peptidase inhibitor 3, Protease inhibitor WAP3, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, PI3, WAP3 and WFDC14, is a secreted protein that contains one WAP domain. Elafin / PI3 consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain at the N-terminus serves as an anchor to localize elafin covalently to specific si... | |||
TMPY-04305 |
Influenza A H5N1 (A/Indonesia/5/2005) Hemagglutinin/HA Protein (R339G & S341R, His)
Harvey rat sarcoma viral oncogene homolog |
H5N1 | Baculovirus Insect Cells |
Influenza A H5N1 (A/Indonesia/5/2005) Hemagglutinin/HA Protein (R339G & S341R, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60 kDa and the accession number is A8HWY8. | |||
TMPY-02847 |
Moesin Protein, Human, Recombinant (aa 1-346, His)
moesin,HEL70 |
Human | E. coli |
Moesin is a member of the ERM family which includes ezrin and radixin. ERM proteins, highly related members of the larger protein 4.1 superfamily, can exist in an active or inactive conformation. It seems that ERM proteins function as cross-linkers between plasma membranes and actin-based cytoskeletons. The sole Drosophila ERM protein, moesin, functions to promote cortical actin assembly and apical-basal polarity. As a result, cells lacking moesin lose epithelial characteristics and adopt invasi... | |||
TMPH-03144 |
SEY1 Protein, Plasmodium knowlesi, Recombinant (His)
|
Plasmodium knowlesi | E. coli |
Probable GTP-binding protein that may be involved in cell development. SEY1 Protein, Plasmodium knowlesi, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 103.5 kDa and the accession number is B3LAJ9. | |||
TMPH-00298 |
Resistin Protein, Bovine, Recombinant (His)
|
Bovine | E. coli |
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes. Resistin Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 13.6 kDa and the accession number is Q762I5. | |||
TMPY-02660 |
Resistin Protein, Mouse, Recombinant (hFc)
resistin,Xcp4,ADSF,Fizz3,Rstn |
Mouse | HEK293 Cells |
Resistin is an adipocytokine, which has been studied for its role in insulin resistance and recently in inflammation. The RETN and CAP1 polymorphisms and gene expression may be potential biomarkers for breast cancer risk. Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. | |||
TMPY-04589 |
Influenza A H5N1 (A/Indonesia/5/2005) Hemagglutinin/HA-specific B cell probe Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N1 | Baculovirus Insect Cells |
Influenza A H5N1 (A/Indonesia/5/2005) Hemagglutinin/HA-specific B cell probe Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 58.2 kDa and the accession number is AHJ09886.1. | |||
TMPH-00508 |
Pro-resilin Protein, Drosophila melanogaster, Recombinant (His & Myc)
|
Fruit fly | E. coli |
Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage. | |||
TMPH-03031 |
P30 adhesin Protein, Mycoplasma pneumoniae, Recombinant (GST & His)
|
Mycoplasma pneumoniae | E. coli |
Adhesin necessary for successful cytadherence and virulence. P30 adhesin Protein, Mycoplasma pneumoniae, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 49.6 kDa and the accession number is P75330. | |||
TMPY-01127 |
Influenza A H5N1 (A/Indonesia/5/2005) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N1 | HEK293 Cells |
Influenza A H5N1 (A/Indonesia/5/2005) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is A8HWY8. | |||
TMPJ-00014 |
Resistin Protein, Human, Recombinant (His)
Resistin,C/EBP-epsilon-regulated myeloid-specific s... |
Human | E. coli |
Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement wit... |