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别名 ISIS-SOD1Rx, BIIB067
Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compound holds potential for amyotrophic lateral sclerosis (ALS) research.

Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compound holds potential for amyotrophic lateral sclerosis (ALS) research.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 mg | ¥ 6,250 | 待询 |
Tofersen 相关产品
| 产品描述 | Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compound holds potential for amyotrophic lateral sclerosis (ALS) research. |
| 体外活性 | Tofersen targets the SOD1 mRNA using antisense oligonucleotides (ASOs) that bind to the SOD1 mRNA by Watson-Crick base pairing. Tofersen activates RNase H1 that destroys the targeted RNA[2]. |
| 别名 | ISIS-SOD1Rx, BIIB067 |
| CAS No. | 2088232-70-4 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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