Name: Tofersen
Brand: TargetMol
SKU: T39498
Price: 1130 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,130

现货

5 mg

¥ 3,170

现货

10 mg

¥ 4,730

现货

25 mg

¥ 7,280

现货

50 mg

¥ 9,830

现货

100 mg

¥ 13,200

现货

生物活性

产品描述	Tofersen (BIIB067) is an antisense oligonucleotide (ASO) that mediates RNase H-dependent degradation of SOD1 (superoxide dismutase 1) mRNA, inhibiting SOD1 protein synthesis for potential use in amyotrophic lateral sclerosis (ALS).
体外活性	Tofersen能够通过反义寡核苷酸(ASO)靶向SOD1 mRNA，并通过沃森-克里克碱基配对与其结合。Tofersen能够激活核糖核酸酶 H1并破坏目标 RNA[2]。
别名	托夫生, ISIS-SOD1Rx, ISISSOD1Rx, ISIS333611, ISIS 333611, BIIB-067, BIIB067

化学信息

CAS No.	2088232-70-4
颜色	White
物理性状	Solid
Sequence	DNA, d([2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2- methoxyethyl)]rG-sp-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]rA-sp-Tsp-A-sp-m5C-sp-A-sp-T-sp-T-sp-T-sp-m5C-sp-T-sp-A-sp-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-sp-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]m5rU)

储存&溶解度

存储	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	H2O: 80 mg/mL, Sonication is recommended.